Detection of Bovine Leukocyte Adhesion Deficiency (BLAD) in Turkish native and Holstein cattle

Akyüz, Bilal; rul, O. Ertu

doi:10.1556/avet.54.2006.2.4

Cited by 18 publications

(27 citation statements)

References 13 publications

(16 reference statements)

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“…The observed frequency of carrier bulls (0.82%) was similar to that reported by Akyüz and Ertuğrul (2006) in Turkish Holsteins (0.84%) and by Ribeiro et al (2000) in Brazilian Gyr bulls (0%). However, it was considerably different from the frequency found in bulls by Patel et al (2007) in Indian Holstein Friesian crossbred cattle (2.99%), Norouzy et al (2005) in Iranian Holsteins (3.3%), Powell et al (1996) in American Holsteins (8.2%), Czarnik et al (2007) in the Polish Holstein-Friesian, Polish Red, and Polish Red-and-White breeds (4.3%), and Meydan et al (2010) in Holstein cows in Turkey (4.0%).…”

Section: Discussionsupporting

confidence: 84%

“…The observed frequency of BLAD carriers among cows (0.76%) may be explained by the fact that this mutation is common in Holstein bulls in different countries (Norouzy et al, 2005;Akyüz and Ertuğrul, 2006;Czarnik et al, 2007;Patel et al, 2007), and carrier bulls were most likely used as founding sires during the establishment of the breed. Three of the 5 affected cows were daughters of the carrier bull evaluated in the study.…”

Section: Discussionmentioning

confidence: 99%

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Incidence of bovine leukocyte adhesion deficiency, complex vertebral malformation, and deficiency of uridine-5-monophosphate synthase carriers in Brazilian Girolando cattle

Paiva¹,

Fonseca²,

Pinto³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Among the various hereditary diseases that have been widely studied in dairy cattle, bovine leukocyte adhesion deficiency (BLAD), deficiency of uridine-5-monophosphate synthase (DUMPS), and complex vertebral malformation (CVM) are noteworthy because of their high impact on overall herd productivity as a consequence of increased calf mortality. The aim of this study was to verify the frequency of carriers of BLAD, CVM, and DUMPS mutant alleles in cows and bulls from the National Girolando Progeny Test carried out in Brazil by using polymerase chain reaction (PCR)-restriction fragment length polymorphism and allele-specific PCR assays. A total of 777 animals were genotyped for BLAD, 783 for CVM, and 122 for DUMPS. The frequencies of carriers for BLAD and CVM were 0.77 and 1.53%, respectively, whereas no carriers of DUMPS were observed.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Incidence of bovine leukocyte adhesion deficiency, complex vertebral malformation, and deficiency of uridine-5-monophosphate synthase carriers in Brazilian Girolando cattle

Paiva¹,

Fonseca²,

Pinto³

et al. 2013

Genet. Mol. Res.

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“…The disease is caused by a point mutation (A→G) of nucleotide 383 in the CD18 gene that results in the substitution of aspartic acid with glycine in the adhesion glycoprotein CD18 (5). This mutation prevents neutrophil leucocytes from passing through the endothelial layer and reaching infected areas (6). Cattle affected by BLAD suffer from loss of teeth, recurrent mucosal infections, death at an early age, and delayed wound healing (5).…”

Section: Introductionmentioning

confidence: 99%

Estimating allele frequencies of some hereditary diseases in Holstein cattlereared in Burdur Province, Turkey

Ağaoğlu¹,

Ağaoğlu²,

Saatcı³

2015

Turk J Vet Anim Sci

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The economics of dairy cattle breeding around the world has been significantly affected by the autosomal recessive hereditary diseases of bovine leukocyte adhesion deficiency (BLAD), factor XI deficiency (FXID), bovine citrullinemia (BC), and deficiency of uridine monophosphate synthase (DUMPS). The aim of this study was to determine BLAD, FXID, BC, and DUMPS alleles in Holstein cattle raised in Burdur Province in Turkey. This study involved taking blood samples randomly from 500 head of Holstein cattle at various dairy farms in different towns in Burdur Province. Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis was employed to identify cows with these diseases. The results showed that the percentages of carrier animals for BLAD and FXID were 2% and 1.8%, respectively, while no DUMPS or BC was found in the study population. This is the first study on BLAD, FXID, BC, and DUMPS in Holstein cattle raised in Burdur Province in Turkey.

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“…The disease is caused by a point mutation that results an aspartic acid to glycine substitution in the adhesion glycoprotein CD18 2, 3 . The mutation prevents neutrofil leucocytes to pass through the endothelial layer and reach to the infection area 4 . BLAD affected cattle have recurrent mucosal infections, loss of teeth, delayed wound healing, persistent neutrophilia and death at an early age …”

Section: Introductionmentioning

confidence: 99%

Kayseri Civarında Yetiştirilen Holştayn İneklerde Sığır Lökosit Bağlanma Yetmezliği (BLAD) Allelinin Belirlenmesi

Akyüz¹,

Ertuğrul²,

Ağaoğlu³

2009

Kafkas Univ Vet Fak Derg

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Bu çalışmanın amacı Kayseri civarında yetiştirilen Holştayn ineklerde sığır lökosit bağlanma yetmezliği (BLAD) allelinin varlığının araştırılmasıdır. Çalışmada 136 Holştayn inekten kan örneği toplanmıştır. Elde edilen PCR ürünlerinde mutasyon bölgesinin belirlenmesi için PCR ürünleri TaqI endonükleaz enzimi ile kesilmiştir. Çalışma sonunda incelenen 136 Holştayn ineğin üçünün BLAD taşıyıcısı oldukları belirlenmiştir. İncelenen 136 baş Holştayn inekte BLAD allelinin frekansı %2.2 olarak hesaplanmıştır.

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Detection of Bovine Leukocyte Adhesion Deficiency (BLAD) in Turkish native and Holstein cattle

Cited by 18 publications

References 13 publications

Incidence of bovine leukocyte adhesion deficiency, complex vertebral malformation, and deficiency of uridine-5-monophosphate synthase carriers in Brazilian Girolando cattle

Incidence of bovine leukocyte adhesion deficiency, complex vertebral malformation, and deficiency of uridine-5-monophosphate synthase carriers in Brazilian Girolando cattle

Estimating allele frequencies of some hereditary diseases in Holstein cattlereared in Burdur Province, Turkey

Kayseri Civarında Yetiştirilen Holştayn İneklerde Sığır Lökosit Bağlanma Yetmezliği (BLAD) Allelinin Belirlenmesi

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