Detailed micro-particle deposition patterns in the human nasal cavity influenced by the breathing zone

Shang, Yidan; Inthavong, Kiao; Tu, Jiyuan

doi:10.1016/j.compfluid.2015.02.020

Cited by 95 publications

(48 citation statements)

References 51 publications

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“…The lung airway model used in this study was reconstructed from computed tomography (CT) images of a healthy adult. Detailed model reconstruction and its verification can be referred from author's previous work (Dong et al, 2017;Shang et al, 2015). The model (Fig.…”

Section: The Lung Airway Modelmentioning

confidence: 99%

Detailed computational analysis of flow dynamics in an extended respiratory airway model

Shang

Dong

Tian

et al. 2019

Clinical Biomechanics

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Section: The Lung Airway Modelmentioning

confidence: 99%

Detailed computational analysis of flow dynamics in an extended respiratory airway model

Shang

Dong

Tian

et al. 2019

Clinical Biomechanics

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“…Xi et al (2016) showed that the nostril inlet orientation has significant influence on eventual particle deposition, as it is the first point of interaction between the inhaled particles and the internal nasal anatomy. Doorly et al (2008), Taylor (2010), and Shang et al (2015b) corroborate the influence of the nostril orientation by including the outer face geometry. Figure 12 shows the extent of outer breathing zone influence.…”

Section: Micron Particle Depositionmentioning

confidence: 53%

“…The deposition of non-spherical particles such as fibrous particles, pollen, and drug particles in a human nasal cavity Fig. 14 Representation of discrete particle release locations for the "with-face" model. 10 5 particles were released throughout the external domain uniformly (Shang et al, 2015b; reproduced with permission © Elsevier Ltd. 2015). is treated differently to spherical particles.…”

Section: Non-spherical Particle Depositionmentioning

confidence: 99%

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From indoor exposure to inhaled particle deposition: A multiphase journey of inhaled particles

Inthavong

2019

Exp. Comput. Multiph. Flow

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Indoor air quality and its effect on respiratory health are reliant on understanding the level of inhalation exposure, particle inhalability, and particle deposition in the respiratory airway. In the indoor environment, controlling airflow through different ventilation systems can reduce inhalation exposure. This produces a wide variety of complex flow phenomena, such as recirculation, coanda flow, separation, and reattachment. Airborne particles drifting through the air, that move within the breathing region become inhaled into nasal cavity the nostrils. Studies have developed the aspiration efficiency to assist in predicting the fraction of inhaled particles. Inside the nasal cavity, micron and submicron particle deposition occurs in very different ways (inertial impaction, sedimentation, diffusion) and different locations. In addition, fibrous particles such as asbestos are influenced by tumbling effects and its deposition mechanism can include interception. Indoor fluid-particle dynamics related to inhalation exposure and eventual deposition in the respiratory airway is presented. This study involves multidisciplinary fields involving building science, fluid dynamics, computer science, and medical imaging disciplines. In the future, an integrated approach can lead to digital/in-silico representations of the human respiratory airway able to predict the inhaled particle exposure and its toxicology effect.

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“…Particles were uniformly released on a hemisphere with 3 cm in radius and with the centre at the nose tip. The hemisphere was located outside the breathing region that proposed by Shang et al (2015b) to minimise the influence of near-nostril biased airflow pattern on particle trajectories. This releasing condition has been widely adopted by previous published studies (Tian et al, 2017a(Tian et al, , 2017b(Tian et al, , 2019Dong et al, 2018;Xu et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

Numerical assessment of ambient inhaled micron particle deposition in a human nasal cavity

Shang

Inthavong

2019

Exp. Comput. Multiph. Flow

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Understanding the particle exposure characteristics in human respiratory airways plays important roles in assessing the therapeutic or toxic effects of inhaled particles. In this study, numerical modelling approach was used to investigate micron-sized particle deposition in an anatomically realistic human nasal cavity. Flow rate of 15 L/min representing typical normal breathing rate for an adult was adopted, and particles were passively released from the ambient air adjacent to the nostrils. Through introducing a surface mapping technique, the 3D nasal cavity was "unwrapped" into a 2D planar domain, which allows a complete visual coverage of the spatial particle deposition in the intricate nasal cavity. Furthermore, deposition enhancement factor was applied to extract regional deposition concentration intensity relative to background intensity of the whole nasal passage. Results show that micron particle exposure in the nasal cavity is closely associated with nasal anatomical shape, airflow dynamics, and particle inertia. Specifically, the main passage of the nasal cavity received high particle deposition dosage, especially for larger micron-sized particles due to increased particle inertia. The nasal vestibule exhibited limited particle filtration effect and most deposited particles in this region concentrated posteriorly.

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Detailed micro-particle deposition patterns in the human nasal cavity influenced by the breathing zone

Cited by 95 publications

References 51 publications

Detailed computational analysis of flow dynamics in an extended respiratory airway model

Detailed computational analysis of flow dynamics in an extended respiratory airway model

From indoor exposure to inhaled particle deposition: A multiphase journey of inhaled particles

Numerical assessment of ambient inhaled micron particle deposition in a human nasal cavity

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