Design and synthesis of novel nucleobase-based barbiturate derivatives as potential anticancer agents

Dhorajiya, Bhaveshkumar D.; Ibrahim, Ahmed S.; Badria, Farid A.; Dholakiya, Bharatkumar Z.

doi:10.1007/s00044-013-0683-4

Cited by 28 publications

(14 citation statements)

References 14 publications

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“…The completion of reaction was confirmed by TLC. This reaction follows the mechanism as shown in (Scheme 2) and (Scheme 3) (10,11). The structures of the furnished analogues are shown in Table 1.…”

Section: Methodsmentioning

confidence: 89%

“…Electrospray ionization mass spectrometry (ESIMS): m/z 277.91 (M + 2) (8). All synthesized new derivatives B (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) showed the strong absorption bands (λ max) in the range of 279.76-374.6 nm owing to the π-π* transition as well as presence of exocyclic CH of the barbituric acid in their UV spectra.…”

Section: Resultsmentioning

confidence: 99%

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Green chemistry multicomponent protocol for formylation and Knoevenagel condensation for synthesis of (Z)-5-arylaminomethylene pyrimidine 2, 4, 6-trione derivatives in water

Dhorajiya

Dholakiya

2014

Green Chemistry Letters and Reviews

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Section: Methodsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Green chemistry multicomponent protocol for formylation and Knoevenagel condensation for synthesis of (Z)-5-arylaminomethylene pyrimidine 2, 4, 6-trione derivatives in water

Dhorajiya

Dholakiya

2014

Green Chemistry Letters and Reviews

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“…Cytotoxicity was determined as the concentration that caused 50% loss of the cell monolayer (IC 50 ). 5‐FU was used as a standard anticancer drug for comparison . CP1 and CP2 were tested for cytotoxicity against four tumour cell lines: HePG‐2, MCF‐7, PC3 and HCT‐116.…”

Section: Resultsmentioning

confidence: 99%

“…IC 50 (μM): 1–10 (very strong); 11–20 (strong); 21–50 (moderate); 51–100 (weak); above 100 (non‐cytotoxic) …”

Section: Resultsmentioning

confidence: 99%

Three‐dimensional coordination polymers based on trimethyltin cation with nicotinic and isonicotinic acids as anticancer agents

Etaiw

Fayed

El‐bendary

et al. 2017

Applied Organom Chemis

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Two new coordination polymers, namely [Me3Sn(INA)] (CP1) and [Me3Sn(NA)] (CP2), where INA = isonicotinic acid and NA = nicotinic acid, were characterized using infrared, UV–visible and NMR spectroscopies, thermogravimetric analysis and single‐crystal X‐ray analyses. The structure of CP1 consists of a one‐dimensional coordinated chain which is further extended creating a two‐dimensional layer via hydrogen bonds. The two‐dimensional layers propagate along the corresponding planes creating a three‐dimensional framework by hydrogen bonding and edge‐to‐face π–π stacking. The asymmetric unit of CP2 contains one tin atom and one NA ligand exhibiting 1:1 stoichiometry. The structure of CP2 extends through coordination bonds to form a one‐dimensional zigzag chain which further extends to create a three‐dimensional network via crossing chains and hydrogen bonds. The tin atoms acquire distorted trigonal bipyramid (TBPY‐5) geometry. CP1 and CP2 were designed to investigate their cytotoxic properties against various human cancer cell lines: hepatocellular carcinoma, mammary gland breast cancer, human prostate cancer and colorectal carcinoma. The compounds are good anticancer agents against the tested cell lines. Also they were screened for their antioxidant, anti‐haemolytic, antibacterial and antifungal activities.

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“…Over the last decade, extensive research has focused on multiple synthetic chemotherapeutic agents that are non-invasive, but display low selectivity and severe adverse effects (2).…”

Section: Introductionmentioning

confidence: 99%

Free-B-Ring flavonoids as potential lead compounds for colon cancer therapy

Ibrahim

Sobeh

Ismail

et al. 2014

Molecular and Clinical Oncology

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Abstract. Although flavonoids have been identified as a versatile source of anticancer agents, to the best of our knowledge, no study has yet investigated their anticolon cancer activity in depth. Therefore, the aim of this study was to investigate the association between the structural characteristics of flavonoids and their anticolon cancer activity in the Caco-2 human colon cancer cell line. Our findings demonstrated that the hydroxylation of C5 and C7 in ring A significantly enhanced the anticolon cancer activity of flavonoids over that of 5-fluorouracil, the classic reference cytotoxic agent. By contrast, the glycosylation or the presence of hydroxyl groups in ring B significantly decreased flavonoid anticancer activity. Collectively, these findings suggest a novel, rational design of flavonoid-related compounds that may improve the treatment of colorectal cancer.

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Design and synthesis of novel nucleobase-based barbiturate derivatives as potential anticancer agents

Cited by 28 publications

References 14 publications

Green chemistry multicomponent protocol for formylation and Knoevenagel condensation for synthesis of (Z)-5-arylaminomethylene pyrimidine 2, 4, 6-trione derivatives in water

Green chemistry multicomponent protocol for formylation and Knoevenagel condensation for synthesis of (Z)-5-arylaminomethylene pyrimidine 2, 4, 6-trione derivatives in water

Three‐dimensional coordination polymers based on trimethyltin cation with nicotinic and isonicotinic acids as anticancer agents

Free-B-Ring flavonoids as potential lead compounds for colon cancer therapy

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