Free-B-Ring flavonoids as potential lead compounds for colon cancer therapy

Ibrahim, Ahmed S.; Sobeh, Mohamed; Ismail, Aya A.; Alaa, Ahmed M.; Sheashaa, Hussein; Sobh, Mohamed; Badria, Farid A.

doi:10.3892/mco.2014.278

Cited by 17 publications

(5 citation statements)

References 25 publications

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“…The flavonoid (−) epigallocatechin decreased the viability of human colon cancer cells and other cancer cells [56,57,58] and induced apoptosis [56,58]. Another flavonoid, 3-hydroxyflavone, decreased the viability of Caco-2 cells [59].…”

Section: Discussionmentioning

confidence: 99%

Effect of Juice and Extracts from Saposhnikovia divaricata Root on the Colon Cancer Cells Caco-2

Matusiewicz

Bączek

Kosieradzka

et al. 2019

IJMS

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Colorectal cancer ranks 3rd in terms of cancer incidence. Growth and development of colon cancer cells may be affected by juice and extracts from Saposhnikovia divaricata root. The objective of the research was to analyze the effect of S. divaricata juice and extracts on the viability, membrane integrity and types of cell death of Caco-2 cells. Juice and extracts were analyzed using Ultra-High Performance Liquid Chromatography-Mass Spectrometry (UHPLC-MS) and in respect of the presence of antioxidants, total carbohydrates, protein, fat and polyphenols. The contents of cimifugin β-D-glucopyranoside, cimifugin, 4′-O-glucopyranosyl-5-O-methylvisamminol, imperatorin and protein were the highest in juice. 50% Hydroethanolic extract had the greatest antioxidant potential, concentration of polyphenols and fat. Water extract was characterized by the highest content of glutathione. Juice and 75% hydroethanolic extract contained the most carbohydrates. After the application of juice, 50% extract and the juice fraction containing the molecules with molecular weights >50 kDa, a decrease of the cell viability was noted. Juice and this extract exhibited the protective properties in relation to the cell membranes and they induced apoptosis. The knowledge of further mechanisms of anticancer activity of the examined products will allow to consider their use as part of combination therapy.

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Section: Discussionmentioning

confidence: 99%

Effect of Juice and Extracts from Saposhnikovia divaricata Root on the Colon Cancer Cells Caco-2

Matusiewicz

Bączek

Kosieradzka

et al. 2019

IJMS

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“…It should also be noted that the literature reports several other important biological activities related to these secondary metabolites, including anti-inflammatory, anticholinesterase, anticarcinogenic, cardioprotective, antimicrobial, and antimutagenic properties. 74 Previous studies with different flavonoids [75][76][77] and glycosylated phenylpropanoids 78 hepatoprotective, anticancer, and antidiabetic activities. [79][80][81] Additionally, oleanonic acid has significant leishmanicidal activity against the protozoan Leishmania amazonensis.…”

Section: Comparison Among Mae Uae and Conventional Extraction Methodsmentioning

confidence: 99%

Microwave and ultrasound extraction of antioxidant phenolic compounds from Lantana camara Linn. leaves: Optimization, comparative study, and FT‐Orbitrap MS analysis

de Jesus,

da Silva,

Wisniewski

et al. 2024

Phytochemical Analysis

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IntroductionThe species Lantana camara is used in folk medicine. The biological activities of this medicinal plant are attributable to the presence of various derivatives of triterpenoids and phenolic compounds present in its preparations, indicating excellent economic potential.ObjectiveIn this study, the operational conditions of ultrasound‐assisted extraction (UAE) and microwave‐assisted extraction (MAE) were optimized using Box–Behnken design to improve the total phenolic content (TPC) recovered in hydroethanolic extracts of L. camara leaves.Material and methodsThe TPC, total flavonoid content (TFC), and antioxidant activities of the hydroalcoholic extracts of L. camara, prepared by UAE and MAE under the optimized extraction conditions, were compared with those of the extracts obtained by conventional extraction methods.ResultsUnder the optimal conditions, the extracts obtained by UAE (35% ethanol, 25 min, and a solvent‐to‐solid ratio of 60:1 mL/g) and by MAE (53% ethanol, 15 min, and 300 W) provided high yields of 32.50% and 38.61% and TPC values of 102.89 and 109.83 mg GAE/g DW, respectively. The MAE extract showed the best results with respect to TPC, TFC, and antioxidant activities, followed by extracts obtained by UAE, Soxhlet extraction, decoction, maceration, and infusion, in that order.ConclusionThe results obtained indicate that L. camara may be used as an important source of antioxidant phenolic compounds to obtain products with high biological and economic potential, especially when the extraction process is performed under appropriate conditions using MAE and/or UAE, employing environmentally friendly solvents such as water and ethanol.

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“…In contrary, the presence of glucose moiety or OHd groups in B ring drastically reduced the anticancer activity. In conclusion, FAB-Lab team proposed a novel, hypothesis SAR of flavonoid-colorectal cancer therapy, which may provide a new horizon to better improve management of colorectal cancer [42].…”

Section: Colorectal Cancer Human Breast Carcinoma Triple Breast Cancermentioning

confidence: 99%

Research on Natural Phenolic Compounds in FAB-Lab: Nonconventional Industrial, Pharmaceutical, and Therapeutic Applications

Badria¹

2022

Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications

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Phenolic compounds represent one of the secondary metabolites of plants with pharmaceutical and therapeutic applications. Flavonoids, quinones, bioflavonoids, neo-lignans, xanthones, curcuminoids, tannins, and coumarins are some examples of the major groups of commonly available phenolic compounds in our daily foods, beverages, and spices. From this standpoint, the Liver Research Laboratory (FAB Lab) at Mansoura university, Egypt, established a multidisciplinary research (chemistry, molecular biology, bioinformatics, pharmacology, and pharmaceutics) based on utilization of commonly abundant natural products from plants and agricultural wastes, especially phenolic compounds to meet the goal of applied scientific research in pharmaceutical industry, environment, public health, and to furnish a sustainable well-developed globe. Examples of our concerted efforts, for over 30 years, are in the area of natural products and utilization of environmental waste containing phenolic compounds for various health disorders (cancer, cataract, degenerative diseases, hyperpigmentation, hyperglycemia, skin disorders), nano-, green and click chemistry. This chapter presents a practical model from FAB-Lab to maximize the benefits from phenolic natural products that have not been optimally exploited to establish meaningful scientific applied research. Patents, innovations, and significant publications indexed by the Web of Science and Scopus databases in the journals that occupy the 1st and the 2nd quartile will be presented.

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Free-B-Ring flavonoids as potential lead compounds for colon cancer therapy

Cited by 17 publications

References 25 publications

Effect of Juice and Extracts from Saposhnikovia divaricata Root on the Colon Cancer Cells Caco-2

Effect of Juice and Extracts from Saposhnikovia divaricata Root on the Colon Cancer Cells Caco-2

Microwave and ultrasound extraction of antioxidant phenolic compounds from Lantana camara Linn. leaves: Optimization, comparative study, and FT‐Orbitrap MS analysis

Research on Natural Phenolic Compounds in FAB-Lab: Nonconventional Industrial, Pharmaceutical, and Therapeutic Applications

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