Green chemistry multicomponent protocol for formylation and Knoevenagel condensation for synthesis of (Z)-5-arylaminomethylene pyrimidine 2, 4, 6-trione derivatives in water

Abstract

A green, efficient, and novel one-pot multicomponent protocol was developed to achieve stereoselective (Z)-5-(arylpropenylidine)-2,4,6-pyrimidinetrione derivatives using a three-component reaction involving appropriate aromatic amines, formic acid, and barbituric acid using water as green solvent by conventional thermal heating process. In this way, N-formylation of various amines takes place.

Nucleobase-Based Barbiturates: Their Protective Effect against DNA Damage Induced by Bleomycin-Iron, Antioxidant, and Lymphocyte Transformation Assay

“…After the completion of the reaction, the resulting clear solution was filtered and cooled in an ice bath overnight. The white product formed was filtered, washed with 50 mL of cold water, dried, and recrystallized from acetone to afford compound as a white powder [ 12 ].…”

Design, Synthesis and Comparative Study of Anti-Microbial Activities on Barbituric Acid and Thiobarbituric Acid based Chalcone Derivatives Bearing the Pyrimidine Nucleus

“…After completion of the reaction, the resulting clear solution was filtered and cooled in an ice bath overnight. The white product formed and it was filtered, washed with 50 ml of cold water, dried and recrystallized from acetone to afford compound 3' as a Light yellowish white powder [18][19][20].…”

Organocatalytic clean synthesis of densely functionalized 4H-pyrans by bifunctional tetraethylammonium 2-(carbamoyl)benzoate using ball milling technique under mild conditions

“…These factors are especially important in industry. On the other hand, multicomponent reactions (MCRs), defined as any process in which three or more reactants combine in one pot to generate a product containing all or most atoms of the starting materials, are highly atom efficient (5)(6)(7)(8). Thus, an ideal MCR involves the simultaneous addition of reactants, catalyst, or reagents at the beginning of the reaction and requires that all reactants couple in an exclusive ordered mode under the same reaction conditions (5)(6)(7)(8).…”

“…On the other hand, multicomponent reactions (MCRs), defined as any process in which three or more reactants combine in one pot to generate a product containing all or most atoms of the starting materials, are highly atom efficient (5)(6)(7)(8). Thus, an ideal MCR involves the simultaneous addition of reactants, catalyst, or reagents at the beginning of the reaction and requires that all reactants couple in an exclusive ordered mode under the same reaction conditions (5)(6)(7)(8). Their superior atom economy, resulting in substantial minimization of waste, labour, time, and cost as well as high efficiency, mild conditions, high convergence, and their general compatibility with green solvents, would justify a central place in the toolbox of green synthetic methodologies (5)(6)(7)(8).…”

“…Thus, an ideal MCR involves the simultaneous addition of reactants, catalyst, or reagents at the beginning of the reaction and requires that all reactants couple in an exclusive ordered mode under the same reaction conditions (5)(6)(7)(8). Their superior atom economy, resulting in substantial minimization of waste, labour, time, and cost as well as high efficiency, mild conditions, high convergence, and their general compatibility with green solvents, would justify a central place in the toolbox of green synthetic methodologies (5)(6)(7)(8). Therefore, academic and industrial research groups have increasingly focused on the use of MCRs for synthesizing a broad range of products especially important heterocyclic compounds such as 4H-pyran derivatives nowadays (9,(10)(11)(12).…”