Design and Fabrication of a Novel Dual-Frequency Confocal Ultrasound Transducer for Microvessels Super-Harmonic Imaging

Deng, Xinqi; Xu, Tingnian; Huang, Guoming; Qing-hao, LI; Luo, Liyang; Zhao, Yue; Wu, Zhengjie; Ouyang, Jun; Yang, Xiaofei; Xie, Mingxing; Zhu, Benpeng

doi:10.1109/tuffc.2020.3028505

Cited by 45 publications

(13 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ultra-high frequency PUT could be used as the acoustic tweezer to precisely manipulate a particle, as shown in Figure 3 C. This needle-type PUT could manipulate a single microsphere as small as 3 μm, and therefore has great potential in biomedical applications. Deng et al [ 29 ] developed a PUT with dual frequency (5 MHz transmission and 30 MW reception) for microvascular imaging based on the KLM model. As shown in Figure 3 D, the PUT included double layers of piezoelectric materials (PMN-PT single crystal and PVDF).…”

Section: Traditional Optimization Design Methods For a Putmentioning

confidence: 99%

“… ( A ) Electrical impedance amplitude and phase variation with frequency, pulse-echo waveform, and spectrum of needle piezoelectric ultrasonic transducer (reproduced from [ 26 ]); ( B ) ultrasonic power transfer experimental setup diagram and KLM equivalent circuit diagram (reproduced from [ 26 ]); ( C ) needle-type piezoelectric ultrasonic transducer, 4 um tungsten wire imaging schematic, and acoustic tweezers manipulating particles to form USC patterns (reproduced from [ 27 ]); ( D ) schematic diagram of a dual-frequency confocal transducer (reproduced from [ 28 ]); ( E ) 1-3 piezoelectric composite ultrasound transducer structure, emission voltage response, and simulated impedance (reproduced from [ 29 ]); ( F ) BDF-PT ultrasonic transducer (reproduced from [ 30 ]). …”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Recent Development and Perspectives of Optimization Design Methods for Piezoelectric Ultrasonic Transducers

et al. 2021

View full text Add to dashboard Cite

A piezoelectric ultrasonic transducer (PUT) is widely used in nondestructive testing, medical imaging, and particle manipulation, etc., and the performance of the PUT determines its functional performance and effectiveness in these applications. The optimization design method of a PUT is very important for the fabrication of a high-performance PUT. In this paper, traditional and efficient optimization design methods for a PUT are presented. The traditional optimization design methods are mainly based on an analytical model, an equivalent circuit model, or a finite element model and the design parameters are adjusted by a trial-and-error method, which relies on the experience of experts and has a relatively low efficiency. Recently, by combining intelligent optimization algorithms, efficient optimization design methods for a PUT have been developed based on a traditional model or a data-driven model, which can effectively improve the design efficiency of a PUT and reduce its development cycle and cost. The advantages and disadvantages of the presented methods are compared and discussed. Finally, the optimization design methods for PUT are concluded, and their future perspectives are discussed.

show abstract

Section: Traditional Optimization Design Methods For a Putmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Recent Development and Perspectives of Optimization Design Methods for Piezoelectric Ultrasonic Transducers

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Nanotechnology-based approaches such as gold NPs, silver NPs, magnetic NPs, and quantum dots (QDs) reveal selective target-binding characteristics [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57]. These characteristics make them ideal candidates for the diagnosis and biosensing of E. coli infections [58][59][60][61][62][63]. The binding to specific ligands such as antibodies and enzymes for detecting bacterial infections is due to the surface properties of NPs.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials in the Management of Gram-Negative Bacterial Infections

et al. 2021

View full text Add to dashboard Cite

The exploration of multiplexed bacterial virulence factors is a major problem in the early stages of Escherichia coli infection therapy. Traditional methods for detecting Escherichia coli (E. coli), such as serological experiments, immunoassays, polymerase chain reaction, and isothermal microcalorimetry have some drawbacks. As a result, detecting E. coli in a timely, cost-effective, and sensitive manner is critical for various areas of human safety and health. Intelligent devices based on nanotechnology are paving the way for fast and early detection of E. coli at the point of care. Due to their specific optical, magnetic, and electrical capabilities, nanostructures can play an important role in bacterial sensors. Another one of the applications involved use of nanomaterials in fighting microbial infections, including E. coli mediated infections. Various types of nanomaterials, either used directly as an antibacterial agent such as metallic nanoparticles (NPs) (silver, gold, zinc, etc.), or as a nanocarrier to deliver and target the antibiotic to the E. coli and its infected area. Among different types, polymeric NPs, lipidic nanocarriers, metallic nanocarriers, nanomicelles, nanoemulsion/ nanosuspension, dendrimers, graphene, etc. proved to be effective vehicles to deliver the drug in a controlled fashion at the targeted site with lower off-site drug leakage and side effects.

show abstract

“…The nanoalloy systems have a high surface-to-volume ratio that can significantly affect the therapeutic or diagnostic functioning [5][6][7][8][9][10][11]. Currently, transition bimetallic alloys are gaining popularity due to their enhanced functionalities [12,13]. Likewise, CoNi alloy nanoparticles (NPs) show suitable magnetic properties that can enhance the magnetic resonance signals to diagnose and target malignant cells.…”

Section: Introductionmentioning

confidence: 99%

CoNi alloy nanoparticles for cancer theranostics: synthesis, physical characterization, in vitro and in vivo studies

et al. 2021

View full text Add to dashboard Cite

Nanomaterials are attracting increasing interest in many biomedical fields, including the fight against cancer. In this context, we successfully synthesized CoNi alloy nanoparticles (NPs) by a simple polyol process. The magnetic characteristics of the products were measured by vibration sample magnometry, which revealed that the samples have soft ferromagnetic behavior. The microstructure and morphology were inspected by X-ray diffraction and scanning electron microscopy, respectively. Human cancer cells derived from the breast (MCF7) and oral cavity (C152) and normal cells derived from human umbilical vein endothelial cells (HUVECs) were treated with increasing concentrations of CoNi NPs, and their cytotoxic effect was measured via MTT and lactate dehydrogenase (LDH) leakage assays. We found that treatments by using 12.5 to 400 µg/mL of Co0.5Ni0.5, Co0.6Ni0.4, and Co0.4Ni0.6 NPs were associated with significant concentration-dependent toxicity toward such cell lines and profoundly enhanced LDH leakage following 48 h of exposure (P < 0.05 compared with untreated cells). Besides, a NP dose of 6.25 µg/mL did not affect the survival of HUVECs while leading to marked cell death in MCF7 and C152 cells. In vivo experiments in rats were done to investigate the biochemical and histopathological changes over three weeks, following intraperitoneal administration of Co0.5Ni0.5, Co0.6Ni0.4, and Co0.4Ni0.6 NPs (100 mg/kg). As compared with the controls, the exposure to NPs caused significant elevations in aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, serum creatinine, serum catalase activity, serum superoxide dismutase, and liver malondialdehyde levels. Also, rats treated with Co0.6Ni0.4 NPs showed more severe histopathological changes of the liver and kidney. Our findings represent an essential step toward developing theranostic nanoplatforms for selective cancer treatment.

show abstract

Design and Fabrication of a Novel Dual-Frequency Confocal Ultrasound Transducer for Microvessels Super-Harmonic Imaging

Cited by 45 publications

References 17 publications

Recent Development and Perspectives of Optimization Design Methods for Piezoelectric Ultrasonic Transducers

Recent Development and Perspectives of Optimization Design Methods for Piezoelectric Ultrasonic Transducers

Nanomaterials in the Management of Gram-Negative Bacterial Infections

CoNi alloy nanoparticles for cancer theranostics: synthesis, physical characterization, in vitro and in vivo studies

Contact Info

Product

Resources

About