Design and evaluation of compound metformin/glipizide elementary osmotic pump tablets

Ouyang, Defang; Nie, Song; Li, Wei; Guo, Hong; Liu, Hui; Pan, Weisan

doi:10.1211/0022357056370

Cited by 21 publications

(9 citation statements)

References 8 publications

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“…There was a report of simultaneous delivery of drugs having extremely different solubility profile through elementary osmotic pump using highly water soluble drug as both osmotic agent and active ingredient to deliver it along with water insoluble drug [16]. Based on this report attempt was made to simultaneously deliver NP (water insoluble drug) and MP (highly water soluble drug) using the same approach.…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination

2011

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BackgroundA system that can deliver multi-drug at a prolonged rate is very important for the treatment of various chronic diseases such as diabetes, asthma and heart disease. Controlled porosity osmotic pump tablet (CPOP) system was designed to deliver Nifedipine (NP) and Metoprolol (MP) in a controlled manner up to 12 h. It was prepared by incorporating drugs in the core and coated with various types (PVP, PEG-400 and HPMC) and levels (30, 40 and 50% w/w of polymer) of pore former at a weight gain of 8, 12 & 15%.ResultsFormulation variables like type and level of pore former and percent weight gain of membrane was found to affect the drug release from the developed formulations. Drug release was inversely proportional to the membrane weight but directly related to the level of pore former. Burst strength of the exhausted shell was inversely proportional to the level of pore former, but directly affected by the membrane weight. Results of scanning electron microscopy (SEM) studies showed the formation of pores in the membrane from where the drug release occurred. Dissolution models were applied to drug release data in order to establish the mechanism of drug release kinetics. In vitro release kinetics was subjected to superposition method to predict in vivo performance of the developed formulation.ConclusionThe developed osmotic system is effective in the multi-drug therapy of hypertension by delivering both drugs in a controlled manner.

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Section: Introductionmentioning

confidence: 99%

Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination

2011

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“…Samples were withdrawn at specified time intervals and analyzed using UV-visible spectrophotometer at 276 nm after filtration through 0.45 mm cellulose membrane filters. [29,30]…”

Section: Effect Of Agitational Intensitymentioning

confidence: 99%

Untitled

Payghan

2016

AJP

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Aim: Glipizide (GZ) which is oral hypoglycemic drug belongs to BCS Class II was selected as a model drug to prepare controlled porosity osmotic pump (CPOP) tablet. Materials and Methods: The solubility of GZ was increased by forming its solid dispersion (SD) with polyvinylpyrrolidone (PVP). The GZ-PVP SD (GZ-SD) systems were prepared by physical mixing and spray drying method, and characterized by differential scanning calorimetry, powder X-ray diffraction analysis, Fourier transform-infrared spectroscopy, and scanning electron microscopy (SEM). Results and Discussion: The effect of different formulation variables-such as the level of solubility modifier in the core, membrane weight gain, and level of pore former in the membrane-were studied. Drug release was found to be affected by the level of solubility modifier present in the core. GZ release was inversely proportional to the membrane weight but directly related to the initial level of pore former (PVP, sorbitol) in the membrane. Drug release from the developed formulations was independent of pH and agitational intensity, but dependent on the osmotic pressure of the dissolution media. Conclusion: Results of SEM studies confirmed the formation of pores in the membrane from where the drug release occurred. The formulations were stable after 3 months of accelerated stability studies. The results indicated that CPOP tablet developed using spray dried GZ-SD had excellent zero-order release characteristics in vitro.

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“…Elementary osmotic pump was invented by Theeuwes in 1974 and it essentially contains an active agent having a suitable osmotic pressure, it is fabricated as a tablet coated with semi permeable membrane, usually cellulose acetate. 25 A small orifice is drilled through the membrane coating. (When this coated tablet is exposed to an aqueous environment, the osmotic pressure of the soluble drug inside the tablet draws water through the semipermeable coating and a saturated aqueous solution of drug is formed inside the device.…”

Section: Elementary Osmotic Pump :-mentioning

confidence: 99%

Osmotic Pump Drug Delivery System: A Noval Approach

Singh

Walia

Agarwal

et al. 2013

J. Drug Delivery Ther.

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 This is extremely valuable for patients with chronic illnesses which require the plasma concentrations of a drug to be within its therapeutic range to avoid breakthrough symptoms, for example, overnight management of pain in terminally ill patients  The reduction or avoidance of side effects due to high plasma drug concentrations or 'dose dumping ABSTRACTConventional drug delivery systems have little control over their drug release and almost no control over the effective concentration at the target site. The major problem associated with conventional drug delivery system is unpredictable plasma concentrations. Controlled drug delivery systems offer spatial control over the drug release. Osmotic pumps are most promising systems for controlled drug delivery. These systems are used for both oral administration and implantation. The present review is concerned with the study of drug release systems which are tablets coated with walls of controlled porosity. . Osmotic pump uses the basic principle of osmosis for release of drug(s). Osmotic pumps consist of an inner core containing drug and osmogens, coated with a semi permeable membrane. As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports. Osmotic pumps release drug at a rate that is independent of the pH and hydrodynamics of the dissolution medium. Various patents available for osmotic drug delivery system like Rose-Nelson pump, Higuchileeper pump, higuchi-theeuwes pump and elementary osmotic pump. In this paper, various types of osmotic pump and the basic components of osmotic system tablets have been discussed briefly.

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Design and evaluation of compound metformin/glipizide elementary osmotic pump tablets

Cited by 21 publications

References 8 publications

Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination

Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination

Untitled

Osmotic Pump Drug Delivery System: A Noval Approach

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