Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination

Kumaravelrajan, R.; Narayanan, N.; Suba, V.

doi:10.1186/1476-511x-10-51

Cited by 20 publications

(11 citation statements)

References 23 publications

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“…Individual samples as well as a physical mixture of drug and excipients were weighed to about 5mg in DSC pan (Shimadzu DSC-50, Japan). The sample in the pan was scanned (Kumaravelrajan et al, 2011) in the temperature range of 50-300°C.The heating rate of 20°C min -1 was used and the thermogram obtained was reviewed for evidence of any interactions. Then the themograms were compared with pure samples versus optimized formulation.…”

Section: Compatibility Studies Dscmentioning

confidence: 99%

Development and Evaluation of Controlled Release Formulation of Lamivudine Based on Microporous Osmotic Tablet Technology Using Fructose as Osmogen

Sahoo¹,

Rao²,

Sudhakar³

2017

Indonesian J. Pharm.

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The present study was undertaken to develop controlled release osmotic pump tablets of lamivudine a nucleoside reverse transcriptase inhibitor for the treatment of acquired immune deficiency syndrome (AIDS). The tablets were prepared by wet granulation method using controlled release polymer hydroxyl propyl methyl cellulose (HPMCE5 LV), MCC as a diluent, starch as binder and fructose as osmogen. The coating solution of core tablets was prepared by using cellulose acetate, poly ethylene glycol 400, 600, 4000, 6000 and acetone to a quantity sufficient with sorbitol for different batches. The prepared tablets were evaluated for pre compression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. Among the prepared formulations LF4 batch show 97.78% drug release in 12h. The in vitro release kinetics were analyzed for different batches by different pharmacokinetic models such as zero order, first order, Higuchi, Korsmeye rPeppas and Hixon Crowell model. Short term stability study at 40±2ºC/75±5% RH for three months on the best formulation was performed showing no significant changes in thickness, hardness, friability, drug content and in vitro drug release.

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Section: Compatibility Studies Dscmentioning

confidence: 99%

Development and Evaluation of Controlled Release Formulation of Lamivudine Based on Microporous Osmotic Tablet Technology Using Fructose as Osmogen

Sahoo¹,

Rao²,

Sudhakar³

2017

Indonesian J. Pharm.

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“…7). Of the drug, 80% was released after 8,12, and 20 h with 20, 15, and 10% MS present in the coating layer. As the level of the pore former increased, the membrane became more porous after coming into contact with the aqueous environment, resulting in faster drug release from both the coating layer and the drug layer (11).…”

Section: Effect Of Pore Former Ms Levels On Drug Releasementioning

confidence: 99%

“…One technique involves adding partial immediate-release drug doses in the formulation, but additional processing steps are required that lead to two different release rates, which may be undesirable for mass production (9,10). Thin coatings around the dosage form is an alternative approach to provide highpermeability and fast initial release (11,12). However, the thin coating lacks strength and often bursts in use or provides insufficient protection to the dosage form which becomes vulnerable to damage during handling (2).…”

Section: Introductionmentioning

confidence: 99%

Model Drug as Pore Former for Controlled Release of Water-Soluble Metoprolol Succinate from Ethylcellulose-Coated Pellets Without Lag Phase: Opportunities and Challenges

Wang¹,

Dai²,

Chang

et al. 2014

AAPS PharmSciTech

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Abstract. The objective of the present study was to evaluate the feasibility of using model drug metoprolol succinate (MS) as a pore former to modify the initial lag phase (i.e., a slow or non-release phase in the first 1-2 h) associated with the drug release from coated pellets. MS-layered cores with high drug-layering efficiency (97% w/w) were first prepared by spraying a highly concentrated drug aqueous solution (60% w/w, 70°C) on non-pareils without using other binders. The presence of MS in ethylcellulose (EC) coating solution significantly improved the coating process by reducing pellets sticking, which often occurs during organic coating. There may be a maximum physical compatibility of MS with EC, and the physical state of the drug in the functional coating layer of EC/MS (80:20) was simultaneously crystalline and noncrystalline (amorphous or solid molecule solution). The lag phase associated with hydroxypropylcellulose (HPC) as a pore former was not observed when MS was used as a pore former. The drug release from EC/ MS-coated pellets was pH independent, inversely proportional to the coating levels, and directly related to the pore former levels. The functional coating layer with MS as a pore former was not completely stabilized without curing. Curing at 60°C for 1 day could substantially improve the stability of EC/MScoated pellets. The physical state of the drug in the free film of EC/MS (85:15) changed partially from amorphous to crystal when cured at 60°C for 1 day, which should be attributed to the incompatibility of the drug with EC.

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“…In this line of research, we reported controlled porosity osmotic pump [22] and sandwich osmotic pump tablet [23] for NP and MP combination.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Kumaravelrajan¹

2016

AJP

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Introduction: A system that can deliver multidrugs at a controlled rate is very important to the treatment of various chronic diseases such as diabetes, asthma, and hypertension. In general, both highly and poorly water-soluble drugs are not good candidates for elementary osmotic delivery, so in the present investigation nifedipine-hydroxyproyl-β-cyclodextrin (1:1) inclusion complex was used to modulate the solubility of nifedipine (NP) within the core and metoprolol was used not only as the active ingredient but also as osmotic agent. Materials and Methods: NP-cyclodextrin complex was prepared by coprecipitation method. The tablets were prepared and coated with cellulose acetate phthalate-containing dibutyl phthalate as plasticizer at various concentrations. The coated tablets drilled for orifice. The orifice size, level of plasticizer, and coating thickness were used as formulation variables. Finally, the optimized formulation was studied for different pH, agitational speed, and release mechanism. The optimized formulation was also subjected to in vivo prediction for the desired C max and C min using superposition method. Results: Formulation variables such as orifice size, level of plasticizer, and coat thickness of semipermeable membrane were found to affect the drug release from the developed formulations. The optimal elementary osmotic pump was found to deliver both drugs at a rate of approximately zero order for up to 10 h independent of pH and agitational intensity but dependent on the osmotic pressure of the release media. Conclusion: Hence, the prototype design of the system could be applied to other combinations of drugs used for cardiovascular diseases, diabetes, etc.

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Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination

Cited by 20 publications

References 23 publications

Development and Evaluation of Controlled Release Formulation of Lamivudine Based on Microporous Osmotic Tablet Technology Using Fructose as Osmogen

Development and Evaluation of Controlled Release Formulation of Lamivudine Based on Microporous Osmotic Tablet Technology Using Fructose as Osmogen

Model Drug as Pore Former for Controlled Release of Water-Soluble Metoprolol Succinate from Ethylcellulose-Coated Pellets Without Lag Phase: Opportunities and Challenges

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