Abstract:Aim: Glipizide (GZ) which is oral hypoglycemic drug belongs to BCS Class II was selected as a model drug to prepare controlled porosity osmotic pump (CPOP) tablet. Materials and Methods: The solubility of GZ was increased by forming its solid dispersion (SD) with polyvinylpyrrolidone (PVP). The GZ-PVP SD (GZ-SD) systems were prepared by physical mixing and spray drying method, and characterized by differential scanning calorimetry, powder X-ray diffraction analysis, Fourier transform-infrared spectroscopy, and… Show more
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