Depleting levels of endogenous anti-oxidant superoxide dismutase in oral sub-mucous fibrosis: A systematic review and meta-analysis

Mohideen, Khadijah; Krithika, Chandrasekaran; Jeddy, Nadeem; Shamsuddin, Shaheen V; Basheer, Sulphi Abdul; Sainudeen, Shan; Alomar, Asma Ahmed; Sahly, Samirah Ahmed; Mushtaq, Shazia; Raj, A. Thirumal; Zanza, Alessio; Testarelli, Luca; Patil, Shankargouda

doi:10.1016/j.jobcr.2022.04.003

Cited by 3 publications

(6 citation statements)

References 43 publications

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“…MDA, as the end product of lipid peroxidation, can reflect the degree of body damage . The antioxidant system of cells scavenges free radicals, preventing free radical chain reactions and lipid peroxidation . Several mechanisms can protect organisms from oxygen-free radical damage, the most important being the role of antioxidant enzymes such as SOD, GSH-Px, and CAT.…”

Section: Discussionmentioning

confidence: 99%

“…SOD is the main enzyme in the antioxidant system of cells or organisms that can catalyze the disproportionation of superoxide radicals (O2 – ) to generate oxygen and hydrogen peroxide. CAT and GSH-Px can decompose hydrogen peroxide (H 2 O 2 ) and prevent the formation of active hydroxyl radicals, reflecting the ability of cells to remove ROS and resist oxidative damage. , …”

Section: Discussionmentioning

confidence: 99%

“…CAT and GSH-Px can decompose hydrogen peroxide (H 2 O 2 ) and prevent the formation of active hydroxyl radicals, reflecting the ability of cells to remove ROS and resist oxidative damage. 22,23 Mitochondria are the primary source of ROS production. Superfluous ROS can cause mitochondrial membrane damage, alter mitochondrial membrane permeability, reduce MMP, and release apoptotic factors, which activate caspases and eventually lead to cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…22 The antioxidant system of cells scavenges free radicals, preventing free radical chain reactions and lipid peroxidation. 23 Several mechanisms can protect organisms from oxygen-free radical damage, the most important being the role of antioxidant enzymes such as SOD, GSH-Px, and CAT. SOD is the main enzyme in the antioxidant system of cells or organisms that can catalyze the disproportionation of superoxide radicals (O2 − ) to generate oxygen and hydrogen peroxide.…”

Section: Discussionmentioning

confidence: 99%

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Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways

Shi

Huang

et al. 2023

ACS Chem. Neurosci.

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Monacolin K (MK), a polyketo secondary metabolic compound of the mold genus Monascus, can promote the apoptosis of malignant cancer cells, possessing potential antitumor properties. However, its mechanism of action on gliomas remains unclear. Here, we explored and investigated the potential of the monacolin K's antitumor effect on human glioma U251 cells and its possible molecular mechanism. Results showed that the application of 10 μM monacolin K inhibited the proliferation of U251 cells, with an inhibitory rate of up to 53.4%. Additionally, monacolin K induced the generation of reactive oxygen species and activated mitochondria-mediated pathways, including decreased MMP, activation of caspase3/caspase9, decreased Na + /K + -ATPase and Ca 2+ -ATPase activities, and disruption of the antioxidant system, resulting in the disruption of intracellular reduction−oxidation homeostasis. Monacolin K also activated MAPK and NF-κB pathways, upregulating P38 activity and downregulating JNK/ERK/ P65/IκBα expression, ultimately leading to apoptosis of U251 cells. Importantly, monacolin K was not cytotoxic to normal human cells, hUC-MSCs. We concluded that monacolin K can induce apoptosis in U251 cells by triggering ROS-mediated oxidative damage and regulating MAPKs and NF-κB pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways

Shi

Huang

et al. 2023

ACS Chem. Neurosci.

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“…This demonstrates the role of oxidative stress in the pathogenesis of OSMF. 5,6 The objectives of clinical treatments are to relieve troublesome symptoms and improve mouth opening to enhance the quality of life for patients. Current methods of treating OSMF vary as there is no standardized treatment protocol.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant treatments in patients with oral submucous fibrosis: A systematic review

Pérez‐Leal,

Lanciano,

Flacco

et al. 2023

J Oral Pathology Medicine

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IntroductionOral submucous fibrosis (OSMF) is a well‐known precancerous oral lesion, characterized by scarring, tissue fibrosis, and premalignant lesions. The goal of clinical treatment is to reduce inflammation and improve patients' quality of life by enhancing mouth opening among others. Antioxidant treatment has shown promising results in inducing regression of lesions and preventing OSMF in high‐risk individuals. This study investigates the effectiveness of various antioxidant agents against OSMF.Materials and MethodsThe study followed PRISMA guidelines and searched three scientific databases: PubMed, Web of Science, and Scopus, using specific algorithms related to “antioxidant treatment,” “burning sensation,” and “mouth opening.” The quality assessment of controlled clinical studies adhered to Cochrane guidelines.ResultsThe analysis included 19 clinical trials comparing different treatments, including various antioxidants. Aloe vera, curcumin, and lycopene, among others, showed positive outcomes in treating OSMF by improving burning sensation, mouth opening, tongue protrusion, and cheek flexibility.ConclusionAntioxidant therapies are found to be effective in treating OSMF, even when compared to conventional treatments such as corticosteroids. The study highlights the need for further research and standardization of clinical protocols.

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Alteration of salivary LPO, MDA, LDH, glutathione, GPx, SOD and vitamins in oral submucous fibrosis: A three-level meta-analysis study

Surboyo,

Merdietio Boedi,

Mahdani

et al. 2024

Clinical Biochemistry

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Depleting levels of endogenous anti-oxidant superoxide dismutase in oral sub-mucous fibrosis: A systematic review and meta-analysis

Cited by 3 publications

References 43 publications

Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways

Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways

Antioxidant treatments in patients with oral submucous fibrosis: A systematic review

Alteration of salivary LPO, MDA, LDH, glutathione, GPx, SOD and vitamins in oral submucous fibrosis: A three-level meta-analysis study

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