Dennettia tripetala (Pepper Fruit), a review of its ethno-medicinal use, phyto-constituents, and biological properties

Abstract

There has been tremendous growth in field of herbal medicine as therapeutic agents. Dennettia tripetala, is known to possess ethnomedicinal properties and has been used for centuries in the Ayurvedic system of medicine for the treatments of various diseases. The present review provides detailed description on the distribution, ethno-medicinal use, phyto-constituents, and biological properties of the plant that justifies its use as a potential therapeutic agent in management of different diseases. The phyto chemical composition of Dennettia tripetala include alkaloids, tannins, saponins, flavonoids, terpenoids, steroids and cardiac glycosides while it biological activities include antioxidant, antidiabetic, antibacterial, antihypertensive, anticonvulsant, antitrypanosomal, antimalarial, anti-inflammatory and cytotoxic properties among others. In conclusion, Dennettia tripetala contains various nutritional and phytochemicals compositions that make it valuable for pharmacological purposes.

Phylogenomic inference of the African tribe Monodoreae (Annonaceae) and taxonomic revision of Dennettia, Uvariodendron and Uvariopsis

“…5I ). The species is traditionally used for the anti-rheumatic, stimulant, antioxidant, antimicrobial and analgesic effects of its leaves, fruits, seeds, roots and stems ( Aiyeloja and Bello 2006 ; Ajibesin et al 2008 ; Iseghohi 2015 ; Rafiu and Sonibare 2016 ; Olatokunbo et al 2018 ; Omage et al 2019 ; Muhammed et al 2021 ).…”

“…Ivory Coast: ‘Michiti à petites feuilles’ (Aubréville 145). Nigeria: ‘Mmimmi’ in Igbo, ‘Ata Igebere’ or ‘Igberi’ in Yoruba, ‘Opipi’ in Idoma, ‘Imako’ in Urhobo, ‘Ako’ in Bini and Edo, ‘Nkarika’ in Efik and Ibibio ( Aiyeloja and Bello 2006 ; Ajibesin et al 2008 ; Rafiu and Sonibare 2016 ; Omage et al 2019 ; Muhammed et al 2021 ).…”

Unlocking Nature's Arsenal: Drug design with Zanthoxylum armatum against Malaria

“…Utilizing the online tool Swiss-ADME software, the study employed predictive modeling to assess the absorption, distribution, metabolism, excretion, and toxicity (ADMET) attributes of all phytochemical compounds under investigation. This analytical approach focuses on key pharmacokinetic parameters, encompassing considerations such as blood-brain barrier (BBB) permeability, tissue distribution, gastrointestinal (GI) absorption, metabolism of P-glycoprotein (P-gp) substrate interactions, metabolic effects as an inhibitor of CYP3A4, and the uidity pertinent to plasma membrane absorption [20]..…”

Antiplasmodial effects of aqueous leaf extracts of Senna alata and Dennettia tripetalla in chloroquine-sensitive Plasmodium berghei berghei (NK65) infected mice

“…The P. berghei-infected mouse model has been widely used as a preliminary test for the in vivo activity of potential antimalarial agents, as it provides a preclinical indication of any in vivo potential bioactivity as well as possible toxicity of the sample tested (Ang et al, 2000). Studies on phytochemical analyses of bioactive compounds present in the leaf extracts of Senna alata (L) Roxb and D. tripetalla showed the presence of saponins, phenolic acids, flavonoids, tannins (present as tannic acid), and alkaloids (Onyegeme-Okerenta, et al, 2017a;Muhammed et al, 2021). Similarly, dichloromethane extracts of S. alata and D. tripetalla leaves revealed the presence of secondary metabolites that have been shown to possess pharmacologic activities which may be responsible for the traditional use of these plants for the treatment of various illnesses (Onyegeme-Okerenta and Essien 2021).…”