2000
DOI: 10.1590/s0004-282x2000000300029
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Demência por neurossífilis: evolução clínica e neuropsicológica de um paciente

Abstract: RESUMO -Demência é uma das manifestações da sífilis tardia e caracteriza-se por deterioração cognitiva e alteração do comportamento. Descrevemos um paciente com declínio cognitivo, alterações na personalidade, hiperatividade, alucinações, delírios, diminuição da capacidade de julgamento, perda da memória recente e sinal pupilar de Argyll Robertson devido a neurosífilis. O Mini Exame do Estado Mental (MEEM) foi 16. O líquido cefalorraquideano (LCR) mostrava 82 mg/dl de proteínas, 128 células/mm3 (98% mononuclea… Show more

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Cited by 15 publications
(10 citation statements)
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“…For instance, Fujimoto et al [6] reported a case who presented with immediate, recent and remote memory disturbances. This was consistent with previously reported cases [7,8,9,10,11]. Unfortunately, these studies lacked systematic neuropsychological examinations, and they did not include other dementia patient groups (e.g.…”
Section: Introductionsupporting
confidence: 91%
“…For instance, Fujimoto et al [6] reported a case who presented with immediate, recent and remote memory disturbances. This was consistent with previously reported cases [7,8,9,10,11]. Unfortunately, these studies lacked systematic neuropsychological examinations, and they did not include other dementia patient groups (e.g.…”
Section: Introductionsupporting
confidence: 91%
“…However, mild cognitive impairment could be observed in early stages of neurosyphilis [2]. It should be noted that before his most celebrated discovery, Alois Alzheimer had dedicated several years of his life to the study of the neuropathology of syphilis, which was the theme of his post-doctoral thesis (Habilitationsschrift) [3].…”
Section: Introductionmentioning
confidence: 99%
“…Case reports scattered throughout the medical literature suggest that several different infectious agents can drive dementia development. Rapidly progressive dementia (RPD) can be caused by enterovirus [60], HIV-associated neurocognitive disorders (HAND) bear similarities to AD [61], neuroborreliosis can cause secondary dementia [62], and it is well accepted that syphilis (Treponema pallidum) can cause dementia that abates with timely intravenous (IV) antibiotic treatment [63]. Moreover, end-stage syphilis resulting in general paresis is histopathologically indistinguishable from AD [64].…”
Section: Dementias Caused By Infectious Agentsmentioning
confidence: 99%
“…In addition, cognitive impairment may abate with proper antiinfective treatment such as in cases of HIV [65], syphilis before the development of general paresis [66], and Lyme neuroborreliosis [62]. Vargas et al [63] remark that 'Neurosyphilis should be a part of the differential diagnosis of every patient showing cognitive deterioration and behavior disturbances', a sentiment supported by other clinicians [67]. The parasitic infection cysticercosis caused by larvae of Taenia solium is known to cause dementia in developing countries, and timely initiation of proper treatment results in favorable neurologic outcomes -'reversible dementia' [68,69].…”
Section: Dementias Caused By Infectious Agentsmentioning
confidence: 99%