Neurosyphilis presenting with dementia, chronic chorioretinitis and adverse reactions to treatment: a case report

Mehrabian, Shima; Raycheva, Margarita; Petrova, Elena Petrova; Tsankov, Nikolay; Traykov, Latchezar

doi:10.4076/1757-1626-2-8334

Cited by 25 publications

(17 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For instance, Fujimoto et al [6] reported a case who presented with immediate, recent and remote memory disturbances. This was consistent with previously reported cases [7,8,9,10,11]. Unfortunately, these studies lacked systematic neuropsychological examinations, and they did not include other dementia patient groups (e.g.…”

Section: Introductionsupporting

confidence: 91%

Cognitive Impairment in Mild General Paresis of the Insane: AD-Like Pattern

Wang¹,

Guo²,

Zhou

et al. 2011

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background/Aims: We investigated the clinical and cognitive features of patients with mild general paresis of the insane (GPI) in comparison to Alzheimer’s disease (AD) patients, mild frontotemporal dementia (FTD) patients and normal elderly individuals. Methods: Twelve patients with mild GPI, 24 patients with mild AD, 11 patients with mild FTD and 36 healthy subjects participated in the current study. A comprehensive neuropsychological battery was used to assess memory, language, attention, executive function, visuospatial ability, etc. In addition, cranial MRI were also obtained from the 3 patient groups. Results: Mild GPI showed a similar pattern of cognitive impairments in memory, language and executive function to mild AD, but a mixed pattern of dissimilarities to mild FTD. Mild GPI patients had more complaints and positive signs in the nervous system than mild AD patients, and cranial MRI results showed that mild GPI patients usually had atrophy of the medial temporal lobe. Conclusion: There is an overall decline in cognitive functions of mild GPI patients, which is comparable to that in AD patients, suggesting that there is a wide range of structural changes in the brains of mild GPI patients as well. However, further studies are needed to verify whether these structural changes are similar to those in AD.

show abstract

Section: Introductionsupporting

confidence: 91%

Cognitive Impairment in Mild General Paresis of the Insane: AD-Like Pattern

Wang¹,

Guo²,

Zhou

et al. 2011

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…There are two forms of arteritis: Heubner arteritis, which is the more common form affecting the medium and large arteries, and Nissl-Alzheimer arteritis, which affects the small arteries and arterioles. Other manifestations of meningovascular syphilis include leptomeningeal and cerebral gummas [1,4-6]. …”

Section: Introductionmentioning

confidence: 99%

Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging

et al. 2012

Self Cite

View full text Add to dashboard Cite

BackgroundThis article reports a rare case of active neurosyphilis in a man with mild to moderate dementia and marked hippocampal atrophy, mimicking early onset Alzheimer’s disease. Few cases have so far described bilateral hippocampal atrophy mimicking Alzheimer’s disease in neurosyphilis.Case presentationThe patient presented here is a 33 year old Bulgarian male, whose clinical features include progressive cognitive decline and behavioral changes over the last 18 months. Neuropsychological examination revealed mild to moderate dementia (Mini Mental State Examination score was 16/30) with impaired memory and attention, and executive dysfunction. Pyramidal, and extrapyramidal signs, as well as dysarthria and impairment in coordination, were documented. Brain magnetic resonance imaging showed cortical atrophy with noticeable bilateral hippocampal atrophy. The diagnosis of active neurosyphilis was based on positive results of the Venereal Disease Research Laboratory test/Treponema pallidum hemagglutination reactions in blood and cerebrospinal fluid samples. In addition, cerebrospinal fluid analysis showed pleocytosis and elevated protein levels. High-dose intravenous penicillin therapy was administered. At 6 month follow up, improvements were noted clinically, on neuropsychological examinations, and in cerebrospinal fluid samples.ConclusionThis case underlines the importance of early diagnosis of neurosyphilis. The results suggest that neurosyphilis should be considered when magnetic resonance imaging results indicate mesiotemporal abnormalities and hippocampal atrophy. Neurosyphilis is a treatable condition which requires early aggressive antibiotic therapy.

show abstract

“…Seven were case reports [4][5][6][7][8][9][10], one was a cohort [1], and one was a case series [11]. Study characteristics are summarized in Table 1.…”

Section: Overviewmentioning

confidence: 99%