Defining the Clinical Characteristics of Peyronie’s Disease in Young Men

Abstract

Introduction Peyronie’s disease (PD) is usually seen in men in their fifth decade of life. Aim In this study, we investigated the characteristics of the disease in young men. Main Outcome Measures The demographics, clinical features, and associated comorbidities of the patients with PD were retrospectively reviewed. Methods The findings were compared between men with the disease who were under 40 years of age with those over 40 years. Statistical analyses were conducted to define differentiating features between these two groups. Results Of the 296 patients, 32 were under the age of 40 years and 264 over 40 years. The mean duration of the disease was 2 ± 4 and 6 ± 8 months in the respective age groups. Fifty-six percent of the patients under the age of 40 years and 75% of the patients over this age presented with curvature (P < 0.01). Thirty-seven percent under 40 years and 12% men over 40 years had more than one plaque at presentation (P < 0.01). Dupuytren’s contracture was seen only in patients over 40 years of age. Pain at presentation was found in 75% under the age of 40 years and in 65% over 40 years (P = 0.03). Trauma history was found in 18% under 40 years and in 5% over this age (P < 0.01). Statistical significant differences were found between the groups under and over the age of 40 years for hypertension (P < 0.01) and dyslipidemia (P < 0.01). Diabetes was noted in 50% of the patients under the age of 40 years and in 18% of the patients over this age (P < 0.001). Multivariate analysis of conditions associated in men with PD under 40 years of age showed statistical significant differences for diabetes (P = 0.015), presentation within 6 months (P = 0.004), and having multiple plaques (P = 0.008). Conclusion Young men with PD are more likely to present at an earlier stage of the disease, to have diabetes, and to have more than one plaque at the time of presentation.

The association between Peyronie's and Dupuytren's disease

“…Previous reports concerning coexisting DD in patients presenting with PD show ranges varying from 0.01 to 58.8%, a positive family history for PD in 1-4% and a positive family history for DD in 9.8% (Table 2). 5,9,[14][15][16][17][18][19][20][21][22][23][24] The series from the UK, Italy, Australia and Serbia show the highest percentage of PD patients with coexisting DD. 9,15,17,19,24 The two reports focusing on PD patients o40 years show a lower percentage of coexisting DD.…”

“…13 The literature concerning coexisting DD in patients presenting with PD shows wide ranges varying from 0.01 to 58.8%. 5,9,[14][15][16][17][18][19][20][21][22][23][24] The aim of this study is to investigate the coexistence of DD in a consecutive series of patients with PD and their clinical characteristics, presenting at the outpatient urological clinic of the University Medical Centre Groningen, The Netherlands.…”

Structured Self-Rated Response to Iontophoresis with Verapamil and Dexamethasone in Peyronie’s Disease

“…It can be devastating to both the patient and his partner and may contribute to erectile difficulties. Men suffering from PD are at greater risk of depression, mood disturbances, low self-esteem, emotional distress, and relationship difficulties, and the quality of life of both the patient and partner may be significantly affected [1, 3, 34, 35]. Presence of PD might adversely influence the patient's virility and fear of partner sexual dissatisfaction [36].…”

Review of non-surgical treatment options for Peyronie's Disease

“…This group of investigators previously reported that 48% of patients had curvature progression in a no-treatment natural history observation study. 47 The first randomized, single-blind trial of intralesional verapamil was published in 1998 by Rehman et al 48 Significant improvements were noted in terms of erection [6][7][8][9][10][11][12][13][14][15][16][17][18], and all patients were treatmentnaive before entry into the study. Curvature was measured during duplex ultrasound of a pharmacologically induced erection.…”

“…PD data outcomes are difficult to interpret without a validated questionnaire, and this is further complicated by a reported spontaneous improvement rate of 13-39%. [10][11][12][13] The purpose of this article is to review the contemporary literature on non-surgical therapies for PD, and where possible, focus on randomized, placebo-controlled trials. The recently published guidelines on PD treatment by the International Consultation on Sexual Medicine (ICSM) are noted.…”