Structured Self-Rated Response to Iontophoresis with Verapamil and Dexamethasone in Peyronie’s Disease

Kokab, Abas; Wylie, Kevan; Allen, Patricia; Shetty, Abhijeeth; Davies-South, Debbie

doi:10.1155/2014/957013

Cited by 6 publications

(1 citation statement)

References 32 publications

(38 reference statements)

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“…Studies are continuing on the use of Verapamil, which is also used intralesional, as a topical treatment method. There are data in some studies that Verapamil does not reach the tunica albuginea (33), but dexamethasone and Verapamil applied by ionotophoresis have been shown to reduce the curvature, especially in patients with a curvature degree of less than (30,34).…”

Section: Evidencementioning

confidence: 99%

Non-Surgical Treatment Options for Peyronie s Disease

ÇINAR¹,

Sarı²,

ALKAN³

et al. 2022

acmr

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Peyronie's disease, which occurs with the formation of a fibrous plaque in the tunica albuginea; is a disease that causes some physical problems such as bending and shortening of the penis. There are surgical treatment methods of this disease as well as non-surgical treatment methods. Non-surgical treatment methods, which are grouped under six headings: oral treatments, topical treatments, traction and vacuum treatments, shock wave therapy, intraplate injection treatments, and experimental treatments, can be preferred in cases where the symptoms are not very advanced because they provide advantages in terms of ease of application, accessibility, and cost. Although the only non-surgical treatment method approved by the FDA (U.S. Food and Drug Administration) yet is clostridium collagenase histolikum, which is used in intraplaque injection, studies have shown that other methods also reduce curvature, pain, and plaque volume.

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Section: Evidencementioning

confidence: 99%

Non-Surgical Treatment Options for Peyronie s Disease

ÇINAR¹,

Sarı²,

ALKAN³

et al. 2022

acmr

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Acquired Disorders of Dermal Connective Tissue

Lovell

2016

Rook's Textbook of Dermatology, Ninth Edition

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The subject matter of this chapter comprises the major acquired disorders that affect mainly collagen and elastic tissue. The connective tissue of normal skin is discussed elsewhere. Heritable disorders of connective tissue, such as Ehlers–Danlos syndrome, are covered in another chapter, as are disorders of ground substance, such as the mucinoses and mucopolysaccharidoses. In addition, many disorders, including developmental defects, neoplasms and other reactive or scarring conditions, may involve the connective tissues. Although it can be convenient to separate conditions into disorders affecting collagen or elastic tissue, the distinction is somewhat artificial, as changes in these proteins are generally preceded by abnormal metabolism of other matrix components, such as fibronectin or periostin.

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Evidence-Based Management Guidelines on Peyronie's Disease

Chung

Ralph

Kagioglu

et al. 2016

The Journal of Sexual Medicine

161

194

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Introduction Despite recent advances in our knowledge and treatment strategies in Peyronie's Disease (PD), much remained unknown about this disease. Aim To provide a clinical framework and key guideline statements to assist clinicians in an evidence-based management of PD. Methods A systematic literature search was conducted to identify published literature relevant to PD. The search included all relevant articles published up to June 2015, including preclinical studies and published guidelines. References used in the text were assessed according to their level of evidence, and guideline recommendations were graded based on the Oxford Centre for Evidence-Based Medicine Levels of Evidence. Owing to the paucity of larger series and randomized placebo-controlled trials with regard to surgical intervention, guideline statements are provided as clinical principle or expert opinion. Main Outcome Measures This literature was discussed at a panel meeting, and selected articles with the highest evidence available were used to create consensus guideline statements for the Fourth International Consultation on Sexual Medicine guidelines on PD. Results In addition to existing Third International Consultation on Sexual Medicine guidelines on PD, seven new summary recommendations were created. Conclusion A greater understanding of the scientific basis of PD is greatly needed to address our understanding of the pathophysiology, clinical epidemiology, psychosocial, and diagnostic assessment as well as treatment strategies.

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Structured Self-Rated Response to Iontophoresis with Verapamil and Dexamethasone in Peyronie’s Disease

Cited by 6 publications

References 32 publications

Non-Surgical Treatment Options for Peyronie s Disease

Non-Surgical Treatment Options for Peyronie s Disease

Acquired Disorders of Dermal Connective Tissue

Evidence-Based Management Guidelines on Peyronie's Disease

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