Acquired Disorders of Dermal Connective Tissue

Lovell, C. R.

doi:10.1002/9781118441213.rtd0097

Cited by 3 publications

(3 citation statements)

References 635 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[12][13][14][15] Over time, the dermal lesion becomes atrophic and less pigmented, resulting in striae albae, which shows as depressed atrophic scars with wrinkling surfaces. [16][17][18] Proposed etiologies of SD include physiological states of rapid body change, as seen in pregnancy (striae gravidarum) 19 or pubertal spurts, 20 connective tissue disorders, 21,22 in the setting of increased adrenocorticotropic hormone levels (e.g., Cushing's syndrome/disease). Additionally, oral and excessive topical corticosteroid therapy may contribute to SD development.…”

Section: Introductionmentioning

confidence: 99%

“…25,26 Similarly, patients with connective tissue disorders (e.g., Marfan's syndrome) may express striae secondary to improper connective tissue formation and/or scaffolding. 21,22 Variations in melanogenesis and melanocytic networking density at the epidermal rete ridges may contribute to localized hyper-(striae nigra) or hypopigmentation (striae albae) within affected skin lesions, too. 27 While SD may appear physiologically during adolescence, 28 they may become less visible over time in some individuals, disappearing on their own.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Striae distensae as a diagnostic indicator for eating disorder pathologies

2022

View full text Add to dashboard Cite

Objective This manuscript provides a review of the relationship between patients with an underlying eating disorder (ED) and the presence of striae distensae (SD). Researchers and clinicians have recognized many different skin manifestations associated with EDs. According to the Diagnostic and Statistical Manual of Mental Disorders, EDs include, but are not limited to, anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). The presence of specific skin findings often helps clinicians conclude whether or not a patient may have an underlying ED and require further evaluation. One skin finding associated with an ED with little current literature focus is SD. SD arises from a combination of hormonal imbalances and stretching of the dermis, triggering a local inflammatory response. The presence of SD leaves patients with diminished quality of life. There is no single guideline treatment for SD; however, topical and/or light and laser therapies can be utilized. Method Using online medical literature databases and the PRISMA guidelines, 11 out of 574 articles met the acceptable criteria to be analyzed, emphasizing the lack of current literature on this subject. Results Anxiety and depression were comorbidities demonstrated to be strongly related to AN and obesity, secondary to BED, in patients who developed SD. Higher degrees of suicidal ideation and insomnia, along with lower self‐esteem levels, were more likely to be present in these patients. Conclusion Altogether, this review highlights the importance of continued evaluation of SD and its overall impact on patient's mental health, emphasizing an underlying ED.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Striae distensae as a diagnostic indicator for eating disorder pathologies

2022

View full text Add to dashboard Cite

show abstract

“…SD often arises due to rapid weight change, endocrine dysregulation, or abuse of steroids. [1][2][3] It starts as raised, violaceous, or red lesions (striae rubra) which later develop into hypopigmented or whited wrinkled linear streaks of atrophic depressed scar (striae alba). 4-6 Microscopic characteristics of SD resemble dermal scar with different features of chronicity.…”

mentioning

confidence: 99%

The efficacy and safety of the innovative cold atmospheric‐pressure plasma technology in the treatment of striae distensae: A randomized controlled trial

Suwanchinda

Nararatwanchai

2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background Available current therapeutics modalities for striae distensae (SD) provide inconsistently effective outcomes. There is ongoing research on innovative treatment modalities to find better treatment solutions. Objectives To evaluate the efficacy and safety of innovative cold atmospheric plasma (CAP) technology in the treatment of striae distensae. Methods This study includes twenty‐three patients with striae distensae. The body was divided into two halves. One side was randomly treated with CAP biweekly on the same treated side for five sessions with 30 days follow‐up after the last session. Another half was left untreated. Efficacy assessment was done using patient and observer scar assessment scale (POSAS), patient satisfaction scales, and Antera 3D® skin imaging system. Safety assessment was evaluated using the visual analog scale (VAS) and adverse effects monitoring. Results Patient and observer scar assessment scale, patient and observer overall opinion score, and patient and observer total score in a summary of all rated characteristics, comparing treated and untreated areas, showed a statistically significant reduction in all parameters after one treatment (*p‐value <0.05). Patients rated satisfaction as a great improvement in 52.3%, moderate improvement in 39.1%, extreme improvement in 4.3%, and slight improvement in 4.3%. Adverse effects included small scabs, shallow wounds, and rash. Conclusion Cold atmospheric plasma is a safe and effective, innovative treatment modality for striae distensae with minimal side effects.

show abstract

Carbon nanotubes (CNTs) based advanced dermal therapeutics: current trends and future potential

et al. 2018

View full text Add to dashboard Cite

The search for effective and non-invasive delivery modules to transport therapeutic molecules across skin has led to the discovery of a number of nanocarriers (viz.: liposomes, ethosomes, dendrimers, etc.) in the last few decades. However, available literature suggests that these delivery modules face several issues including poor stability, low encapsulation efficiency, and scale-up hurdles. Recently, carbon nanotubes (CNTs) emerged as a versatile tool to deliver therapeutics across skin. Superior stability, high loading capacity, well-developed synthesis protocol as well as ease of scale-up are some of the reason for growing interest in CNTs. CNTs have a unique physical architecture and a large surface area with unique surface chemistry that can be tailored for vivid biomedical applications. CNTs have been thus largely engaged in the development of transdermal systems such as tuneable hydrogels, programmable nonporous membranes, electroresponsive skin modalities, protein channel mimetic platforms, reverse iontophoresis, microneedles, and dermal buckypapers. In addition, CNTs were also employed in the development of RNA interference (RNAi) based therapeutics for correcting defective dermal genes. This review expounds the state-of-art synthesis methodologies, skin penetration mechanism, drug liberation profile, loading potential, characterization techniques, and transdermal applications along with a summary on patent/regulatory status and future scope of CNT based skin therapeutics.

show abstract

Acquired Disorders of Dermal Connective Tissue

Cited by 3 publications

References 635 publications

Striae distensae as a diagnostic indicator for eating disorder pathologies

Striae distensae as a diagnostic indicator for eating disorder pathologies

The efficacy and safety of the innovative cold atmospheric‐pressure plasma technology in the treatment of striae distensae: A randomized controlled trial

Carbon nanotubes (CNTs) based advanced dermal therapeutics: current trends and future potential

Contact Info

Product

Resources

About