A comprehensive analysis of both the molecular genetic and phenotypic responses of any organism to the space flight environment has never been accomplished because of significant technological and logistical hurdles. Moreover, the effects of space flight on microbial pathogenicity and associated infectious disease risks have not been studied. The bacterial pathogen Salmonella typhimurium was grown aboard Space Shuttle mission STS-115 and compared with identical ground control cultures. Global microarray and proteomic analyses revealed that 167 transcripts and 73 proteins changed expression with the conserved RNA-binding protein Hfq identified as a likely global regulator involved in the response to this environment. Hfq involvement was confirmed with a ground-based microgravity culture model. Space flight samples exhibited enhanced virulence in a murine infection model and extracellular matrix accumulation consistent with a biofilm. Strategies to target Hfq and related regulators could potentially decrease infectious disease risks during space flight missions and provide novel therapeutic options on Earth.

Alternative food initiatives are appearing in many places. Observers suggest that they share a political agenda: to oppose the structures that coordinate and globalize the current food system and to create alternative systems of food production that are environmentally sustainable, economically viable, and socially just. This paper examines the potential of these initiatives through the lens of the concepts of 'alternative and oppositional' social movements and 'militant particularism and global ambition' developed by Raymond Williams and David Harvey. The three sections of this paper review (1) the current discussion of common themes and strategies in agrifood initiatives within the academic literature; (2) the history of these initiatives in California; and (3) results of our interviews with 37 current leaders of California organizations. We suggest that further understanding these initiatives, and success in the goals of the initiatives themselves, requires us to look past their similarities to examine their differences. These differences are related to the social forms and relations that have been established in the places from which these initiatives arise. 'Social justice,' in particular, may be difficult to construct at a 'local' scale. r

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For alternative agrifood social movements, food-system localization is both an ideal and a pathway to resolve environmental, social and economic issues in the food system. This article addresses the potential for equity within food-system localization in practical and conceptual terms. Historical processes have shaped regions and social relations with vast differences in wealth, power and privilege and this has implications for thinking about and enacting equity through food-system localization. If food-system localization efforts are to work toward equity, they must consider inherited material and discursive asymmetries within frameworks of economy, demography, geography and democracy.