Decreased Parotid Saliva Gustin/Carbonic Anhydrase VI Secretion: An Enzyme Disorder Manifested by Gustatory and Olfactory Dysfunction

Henkin, Robert I.; Martin, Brian M.; Agarwal, R. A.

doi:10.1016/s0002-9629(15)40663-9

Cited by 88 publications

(42 citation statements)

References 101 publications

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“…For example, Zn-alpha-2 glycoprotein, prolactin-inducible protein, and cystatin SN were significantly reduced in tasteimpaired patients (Igarashi et al 2008) as well as carbonic anhydrase VI (CAVI), a Zn-protein also called gustin. This protein has been previously related to taste perception due to its role in taste bud development and function (Henkin et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Short-Term Modification of Human Salivary Proteome Induced by Two Bitter Tastants, Urea and Quinine

Quintana

Palicki

Lucchi³

et al. 2009

Chem. Percept.

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Salivary proteome patterns of healthy volunteers (n=12) were compared before and after they tasted bitter solutions made of either urea (0.36M) or quininehydrochloride (40 µM). Relative abundance of 22 and 18 spots was modified 15 min after stimulation by urea and quinine, respectively. Only two spots were common to both tastants, indicating a molecule-specific response. Proteins, relative quantity of which was altered, were agents of the oral cavity defense (e.g., thioredoxin, cystatin, parotid secretory proteins, etc.) and markers of inflammation (transthyretin and transferrin) or enzymes. In particular, the relative abundance of carbonic anhydrase VI, a protein previously described as crucial to taste function, declined after tasting the urea solution.

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Section: Introductionmentioning

confidence: 99%

Short-Term Modification of Human Salivary Proteome Induced by Two Bitter Tastants, Urea and Quinine

Quintana

Palicki

Lucchi³

et al. 2009

Chem. Percept.

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“…Supplementation of zinc is considered to be important for the treatment of such zinc-deficiency symptoms. With respect to hypogeusia, several clinical trials have been performed to assess whether zinc compounds are useful for the improvement of impaired taste sensation (Henkin and Bradley 1970;Schechter et al 1972;Henkin et al 1975Henkin et al , 1999aHeckmann et al 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Zinc plays a crucial role in this process by a zinc containing growth factor, a metalloglycoprotein (carbonic anhydrase (CA) VI) which is found in taste buds (Kivela et al 1999;Leinonen et al 2001). CA VI is depleted in zinc-deficient human (Henkin et al 1975(Henkin et al , 1999a, and zinc-deficient rats causes loss of taste sensitivity as related to loss of CA activity in taste related tissues Goto et al 2000). Zinc deficiency induces a decrease of taste bud cell proliferation in rats, and our previous study showed clear improvement of taste bud cell proliferation by treatment with polaprezinc (Hamano et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Polaprezinc, a zinc compound, is distributed to the lingual epithelium and increases its zinc concentration in zinc-deficient rats

et al. 2009

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“…The first group includes factors such as low salivary flow rate [11], burning mouth [14], candidiasis [34], and the number of amalgam-filled surfaces [37]. The second group consists of factors with systemic origin, i.e., low zinc concentrations [16,27], hormone disturbances [10], head trauma, viral infections, irradiation [7], and adverse effect of medication [1,31]. The third group is comprised of psychological factors such as depression [8,20,21] and stress [22].…”

Section: Introductionmentioning

confidence: 99%

Perceived taste disturbance in adults: prevalence and association with oral and psychological factors and medication

Bergdahl

2002

Clinical Oral Investigations

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Taste disturbance may cause subjective discomfort and impair appetite and food intake. The aim of this study was to estimate the prevalence of perceived taste disturbance and analyze its association to age, gender, whole salivary flow rate, subjective oral dryness, burning mouth, medication, and psychological factors. Five hundred forty-seven men and 656 women aged 20 to 69 years were randomly selected from the Public Dental Health Service register in northern Sweden. Oral complaints were registered and whole salivary flow rate measured. Medication, anxiety, depression, and stress were assessed. Thirty individuals (2.5%), five men (0.9%) and 25 women (3.8%), reported perceived taste disturbances (distorted taste or loss of taste). In men, no individual with taste disturbance was found in the youngest and oldest age groups. The prevalence in the 30-39-year age group was 1.9% and in the 40-49-year group 1.8%. In women, one individual (1%) with taste disturbance was found in the youngest age group. In the 30-39-year group, the prevalence was 3.8%, increasing to 5.1% in the oldest age group. Illness, subjective oral dryness, state anxiety, perceived stress, depression, use of antiasthmatics, and trait anxiety were associated with taste disturbance. It was concluded that perceived taste disturbance might be an interaction of various health factors such as illness and mental condition.

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Decreased Parotid Saliva Gustin/Carbonic Anhydrase VI Secretion: An Enzyme Disorder Manifested by Gustatory and Olfactory Dysfunction

Cited by 88 publications

References 101 publications

Short-Term Modification of Human Salivary Proteome Induced by Two Bitter Tastants, Urea and Quinine

Short-Term Modification of Human Salivary Proteome Induced by Two Bitter Tastants, Urea and Quinine

Polaprezinc, a zinc compound, is distributed to the lingual epithelium and increases its zinc concentration in zinc-deficient rats

Perceived taste disturbance in adults: prevalence and association with oral and psychological factors and medication

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