Polaprezinc, a zinc compound, is distributed to the lingual epithelium and increases its zinc concentration in zinc-deficient rats

Hamano, Hiroki; Yoshinaga, Koji; Tanaka, Takao; Eta, Runa; Horii, Takayuki; Kawabata, Yoshihiro; Furuta, Shigeru; Takei, Makoto

doi:10.1016/j.lfs.2009.10.006

Cited by 11 publications

(7 citation statements)

References 31 publications

(33 reference statements)

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“…We found that zinc restriction during prenatal and postnatal phases induced a significant reduction in body weight evolution and food intake in female offspring from ZnD group, corroborating with the findings of previous described studies [22,34]. This finding may be explained by studies that observed hypogeusia (decreased gustatory sense) in both humans and rats induced by zinc deficiency, leading ultimately in reduction of food consumption [35,36].…”

Section: Discussionsupporting

confidence: 90%

Early-in-life dietary zinc deficiency and supplementation and mammary tumor development in adulthood female rats

Silva

Grassi

Zapaterini

et al. 2017

The Journal of Nutritional Biochemistry

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Zinc deficiency during pregnancy and postnatal life can adversely increase risk of developing human diseases at adulthood. The present study was designed to evaluate whether dietary zinc deficiency or supplementation during the pregnancy, lactation and juvenile stages interferes in the development of mammary tumors induced by 7,12-dimethylbenzanthracene (DMBA) in female Sprague-Dawley (SD) rats. Pregnant female SD rats were allocated into three groups: zinc-adequate diet (ZnA - 35-mg/kg chow), zinc-deficient diet (ZnD - 3-mg/kg chow) or zinc-supplemented diet (ZnS - 180-mg/kg chow) during gestational day 10 (GD 10) until the litters' weaning. Female offspring received the same diets as their dams until postnatal day (PND) 51. At PND 51, the animals received a single dose of DMBA (50 mg/kg, ig) and zinc-adequate diets. At PND 180, female were euthanized, and tumor samples were processed for histological evaluation and gene expression microarray analysis. The ZnD induced a significant reduction in female offspring body weight evolution and in mammary gland development. At late in life, the ZnD or ZnS did not alter the latency, incidence, multiplicity, volume or histological types of mammary tumors in relation to the ZnA group. However, the total tumor number in ZnS group was higher than in ZnA group, accompanied by distinct expression of 4 genes up- and 15 genes down-regulated. The present findings indicate that early-in-life dietary zinc supplementation, differently to zinc deficiency, has a potential to modify the susceptibility to the development of mammary tumors induced by DMBA.

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Section: Discussionsupporting

confidence: 90%

Early-in-life dietary zinc deficiency and supplementation and mammary tumor development in adulthood female rats

Silva

Grassi

Zapaterini

et al. 2017

The Journal of Nutritional Biochemistry

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“…During zinc deficiency, the zinc content in the lingual epithelium would be expected to be low, affecting its regeneration and proliferation as the main consequences. 77 , 78 In addition, low zinc content in such a tissue can decrease carbonic anhydrase activity. 79 Insofar as zinc content in the salivary glands may decline during zinc deficiency, 80 , 81 low salivary zinc content is particularly linked to decreased activity of carbonic anhydrase 6, also called gustin, whose enzyme is a trophic factor that promotes the growth and development of taste buds.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic supplementation with zinc in the management of COVID-19–related diarrhea and ageusia/dysgeusia: mechanisms and clues for a personalized dosage regimen

Santos

2021

Nutrition Reviews

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Zinc supplementation is indicated for diarrhea and taste disorders, which are both features of COVID-19. Nevertheless, this strategy has not been tested for the treatment of these secondary complications in the current pandemic. Through an updated review, a practical appraisal was considered as a means of providing a medical nexus of therapeutic zinc regimens as an adjunct in the management of COVID-19–related diarrhea and ageusia/dysgeusia. While diarrhea and taste disorders are consequences of COVID-19, zinc supplementation is useful for non–COVID-19 patients with these clinical problems. The overwhelming evidence for supplementing with zinc in diarrhea and pneumonia is associated with the treatment of children, while for taste disorders the use of supplementing with zinc is more examined in adults. Whereas COVID-19 is more prevalent in adults, precautions should be exercised not to translate the zinc dosage used for children with diarrhea and taste disorders into the current pandemic. Therapeutic doses of zinc used for adults (∼50–150 mg/day of elemental zinc) could be included in the treatment strategies for COVID-19, but this proposal should be examined through randomized studies.

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“…Fong et al have shown that zinc supplementation rapidly induced apoptosis in esophageal epithelial cells and may have a role in the prevention of esophageal cancer [9]. Koji Yoshinaga et al have demonstrated that polaprezinc increased the low zinc concentration in the lingual epithelium and may improve the cellular functions, especially for the proliferation [10]. Despite the initial evidence on the role of zinc and zinc transporters in cancer prevention, however, to the best of our knowledge, little attention has been paid to zinc-derived compounds [2].…”

Section: Introductionmentioning

confidence: 99%

New Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity

et al. 2018

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Despite the initial evidence on the role of zinc and zinc transporters in cancer prevention, little attention has been paid to the zinc-derived compounds. In the present work, we reported a strategy to prepare a kind of zinc-releasing container with enhanced biocompatibility and release dynamics using ZIF-8 nanocrystals as the sacrificial templates. Transmission electron microscopy (TEM) analysis demonstrated that the ZIF-8 nanocrystals were gradually etched out in the aqueous media within 48 h, resulting in hollow nanocapsules. Notably, we found the self-polymerization of dopamine can form nanoshells around the ZIF-8 nanocrystals, which served as a type of functional membranes during the release of zinc. More interestingly, PDA@ZIF-8-based nanohybrids expressed stronger inhibition to the cancer cell growth, which implied that the nanohybrids could be a drug carrier for chemotherapy. This study broadens the biomedical application of ZIF-8 and also provides a versatile strategy toward the development of multifunctional delivery system.

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Polaprezinc, a zinc compound, is distributed to the lingual epithelium and increases its zinc concentration in zinc-deficient rats

Cited by 11 publications

References 31 publications

Early-in-life dietary zinc deficiency and supplementation and mammary tumor development in adulthood female rats

Early-in-life dietary zinc deficiency and supplementation and mammary tumor development in adulthood female rats

Therapeutic supplementation with zinc in the management of COVID-19–related diarrhea and ageusia/dysgeusia: mechanisms and clues for a personalized dosage regimen

New Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity

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