Decellularized tendon matrix membranes prevent post-surgical tendon adhesion and promote functional repair

Tao, Meihan; Fang, Liang; He, Jing; Ye, Wei; Javed, Rabia; Wang, Weizuo; Yu, Tianhao; Fan, Jun; Tian, Xiaohong; Wang, Xiaohong; Hou, Wei; Ao, Qiang

doi:10.1016/j.actbio.2021.07.038

Cited by 31 publications

(20 citation statements)

References 44 publications

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“…Rapid thermal changes in the freeze-thaw effectively lyse cells and aid in their subsequent removal ( Tao et al, 2021 ). Hence, a single freeze-thaw cycle is commonly used as the first step to reduce the quantities of chemical reagents for liver decellularization ( Cheng et al, 2019 ).…”

Section: Decellularizationmentioning

confidence: 99%

Recent Advances in Liver Engineering With Decellularized Scaffold

Dai

Jiang

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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Liver transplantation is currently the only effective treatment for patients with end-stage liver disease; however, donor liver scarcity is a notable concern. As a result, extensive endeavors have been made to diversify the source of donor livers. For example, the use of a decellularized scaffold in liver engineering has gained considerable attention in recent years. The decellularized scaffold preserves the original orchestral structure and bioactive chemicals of the liver, and has the potential to create a de novo liver that is fit for transplantation after recellularization. The structure of the liver and hepatic extracellular matrix, decellularization, recellularization, and recent developments are discussed in this review. Additionally, the criteria for assessment and major obstacles in using a decellularized scaffold are covered in detail.

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Section: Decellularizationmentioning

confidence: 99%

Recent Advances in Liver Engineering With Decellularized Scaffold

Dai

Jiang

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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“…Acellular biological scaffolds have been widely studied recently and have wide application prospects for tendon and ligament healing [ 95 ]. On the premise that the mechanical properties and ECM structure are well preserved, the acellular biological scaffold also has a better solution to the immunogenicity of transplantation since this scaffold removes the cellular components of tissue [ 96 ]. Acellular biological scaffolds have a good cell structure.…”

Section: Products Of Tendon and Ligament Reconstruction And Repairmentioning

confidence: 99%

Functional biomaterials for tendon/ligament repair and regeneration

Tang

Wang

Xiang

et al. 2022

Regenerative Biomaterials

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With an increase in life expectancy and the popularity of high-intensity exercise, the frequency of tendon and ligament injuries has also increased. Owing to the specificity of its tissue, the rapid restoration of injured tendons and ligaments is challenging for treatment. This review summarises the latest progress in cells, biomaterials, active molecules, and construction technology in treating tendon/ligament injuries. The characteristics of supports made of different materials and the development and application of different manufacturing methods are discussed. The development of natural polymers, synthetic polymers, and composite materials has boosted the use of scaffolds. In addition, the development of electrospinning and hydrogel technology has diversified the production and treatment of materials. First, this paper briefly introduces the structure, function, and biological characteristics of tendons/ligaments. Then, it summarises the advantages and disadvantages of different materials, such as natural polymer scaffolds, synthetic polymer scaffolds, composite scaffolds, and ECM-derived biological scaffolds, in the application of tendon/ligament regeneration. We then discuss the latest applications of electrospun fiber scaffolds and hydrogels in regeneration engineering. Finally, we discuss the current problems and future directions in the development of biomaterials for restoring damaged tendons and ligaments.

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“…Typically, the tendons are decellularized with 5–10 F–T cycles [ 41 ]. In order to effectively decellularize the tendons in a short time, a combination of F–T cycles with detergents such as SDS has been carried out [ 42 ].…”

Section: Decellularization Processmentioning

confidence: 99%

“…One of the transcription factors that is found explicitly in tendon precursor and mature tendon cells is SCX, thus becoming a marker for tendon and ligament tissues. COL3A1, TNC, and TNMD are genes that are related to tendon ECM ( Table 1 ), while LAMA1 is related to signaling, cell adhesion, migration, and differentiation [ 11 , 12 , 42 ]. Collagen type 1 is expressed by mature tenocytes.…”

Section: Analysis Of the Decmmentioning

confidence: 99%

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Decellularized Extracellular Matrix-Based Bioinks for Tendon Regeneration in Three-Dimensional Bioprinting

Khalak

García‐Villén

Ruiz‐Alonso

et al. 2022

IJMS

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In the last few years, attempts to improve the regeneration of damaged tendons have been rising due to the growing demand. However, current treatments to restore the original performance of the tissue focus on the usage of grafts; although, actual grafts are deficient because they often cannot provide enough support for tissue regeneration, leading to additional complications. The beneficial effect of combining 3D bioprinting and dECM as a novel bioink biomaterial has recently been described. Tendon dECMs have been obtained by using either chemical, biological, or/and physical treatments. Although decellularization protocols are not yet standardized, recently, different protocols have been published. New therapeutic approaches embrace the use of dECM in bioinks for 3D bioprinting, as it has shown promising results in mimicking the composition and the structure of the tissue. However, major obstacles include the poor structural integrity and slow gelation properties of dECM bioinks. Moreover, printing parameters such as speed and temperature have to be optimized for each dECM bioink. Here, we show that dECM bioink for 3D bioprinting provides a promising approach for tendon regeneration for future clinical applications.

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Decellularized tendon matrix membranes prevent post-surgical tendon adhesion and promote functional repair

Cited by 31 publications

References 44 publications

Recent Advances in Liver Engineering With Decellularized Scaffold

Recent Advances in Liver Engineering With Decellularized Scaffold

Functional biomaterials for tendon/ligament repair and regeneration

Decellularized Extracellular Matrix-Based Bioinks for Tendon Regeneration in Three-Dimensional Bioprinting

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