Daily antibiotic cost of nosocomial infections in a Turkish university hospital

İnan, Dilara; Saba, Rabin; Günseren, Filiz; Öngüt, Gözde; Turhan, Özge; Yalcin, Ata Nevzat; Mamikoglu, Latife

doi:10.1186/1471-2334-5-5

Cited by 40 publications

(36 citation statements)

References 22 publications

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“…13 Study conducted at Belgium and Turkey the mean overall daily antimicrobial cost was €114.25 and $89.64 respectively. 16,17 Both were higher as compared to our study. Cost of inotropes, cardiovascular drugs and anticholinergic drugs were significantly (p<0.05) higher in Group A patients.…”

Section: Analysis Of Cost Of Group Of Drugs Per Patientcontrasting

confidence: 73%

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Analysis of Cost of Antimicrobial Therapy along with Cost of Concomitant Drug Therapy in Patients Admitted in Critical Care Unit (CCU) at Charitable Trust Hospital In India

Shelat¹,

Kumbar²

2015

J YOUNG PHARM

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Objective: To study the cost of antimicrobial therapy along with concomitant drug therapy in Critical Care Unit (CCU). Material and Method: Study was conducted at charitable trust hospital of metro city in India. Total 270 patients admitted in CCU were included. Daily bill of drugs from patients were taken and cost mentioned in the bill was recorded. Currency was converted from Indian to United States currency (`54.81 INR = 1$USD). Data were analyzed by student 't' test, x 2 test and Z test. Results: Patients were divided according to Group A (directly/first admitted in CCU) and Group B (transferred from ward/operation theatre to CCU). Duration of hospital stay in CCU, patients on ventilator support, mortality were significantly (p<0.05) higher in directly admitted Group A patients as compared to transferred Group B patients. Cost of antimicrobial therapy was significantly (p<0.05) higher in Group A as compared to Group B patients and accounted more than one third to cost of total drug therapy. Cost of concomitant drugs like inotropes was significantly (p<0.05) higher in Group A patients. Cost of gastrointestinal drugs and analgesics were significantly (p<0.05) higher in Group B patients. Cost of antimicrobials like piperacillin+tazobactam, cefoperazone+sulbacatm were significantly (p<0.05) higher in Group A patients. Cost of amikacin and metronidazole per patient were significantly (p<0.05) higher in Group B. Cost of beta lactam antimicrobials like amoxicillin+clavulinate, piperacillin+tazobactam and cefoperazone+sulbacatm accounted more than 40% of cost of antimicrobials. Conclusion: Cost of antimicrobial therapy was higher in directly admitted Group A patients in CCU. Cost of antimicrobials per patient was accounted more than one third of total cost of drug therapy in CCU. In antimicrobials cost of beta lactam antimicrobials was higher as compared to other antimicrobials.

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Section: Analysis Of Cost Of Group Of Drugs Per Patientcontrasting

confidence: 73%

“…Both were higher as compared to our study. 17 Both antimicrobial agents were prescribed as broad spectrum antimicrobials in our study. Cost of ceftriaxone+sulbactam were significantly higher in Group A patients ($10.51 ± 8.3) which was lower as compared to study conducted at Turkey ($197 to $394).…”

Section: Analysis Cost Of Antimicrobial Agents Per Patientmentioning

confidence: 99%

Analysis of Cost of Antimicrobial Therapy along with Cost of Concomitant Drug Therapy in Patients Admitted in Critical Care Unit (CCU) at Charitable Trust Hospital In India

Shelat¹,

Kumbar²

2015

J YOUNG PHARM

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“…It was re por ted that abo ut 30% of the pa ti ents sta ying in hos pi tals we re using an ti bi o tics and 25 to 65% of antibiotic use was inap prop ri a te. In Ak de niz Uni ver sity Hospi tal, inap prop ri a te use of an ti bi o tics was 43% 26 and in our study, inap prop ri a te use of an ti bi o tics was 36.8%. Mul tip le an ti bi o tic re sis tan ce in gram ne ga ti ve bac te ri a (En te ro bac ter spp., P. ae ru gi no sa, K. pne u mo ni a e and Aci ne to bac ter spp.)…”

Section: Discussionmentioning

confidence: 66%

“…25 In Ak de niz Uni ver sity Me di cal Fa culty Hos pital, no so co mi al in fec ti on ra tes chan ged bet we en 1.6% and 47.4% with the hig hest ra tes in the re ani ma ti on unit 1 (44.7%), unit 2 (%44.6) and in ternal me di ci ne ICU (17.8%). 26 In our study, the in fec ti on ra te in our in ter nal me di ci ne ICU was 38% and in ac cor dan ce with nati onal and fo re ign stu di es. The re a son of hig her infec ti on ra te com pa red to the ot her units may be exp la i ned by the ad di ti o nal con tri bu ti ng fac tors to in fec ti on de ve lop ment; the ma jo rity of pa ti ents we re in ne ed of pul mo nary sup port, mo re in va si ve pro ce du res we re app li ed and wor se general sta tus of the pa ti ents fol lo wed in this unit.…”

Section: Discussionmentioning

confidence: 91%

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An Overall View on Nosocomial Infections in an Intensive Care Unit

Soysal¹,

Yusufoğlu²,

Karakuş³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The purpose of this study was to determine the pathogenic agents in nosocomial infections and measure their antimicrobial sensitivity in the intensive care unit. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Between January and October 2007, 250 patients were examined in the intensive care unit of the 1st Internal Medicine Department of Atatürk Training and Research Hospital, which was opened in January 2007. Active and prospective surveillance method based on laboratory data and patients' diagnosis was used for 95 of these patients with hospital-acquired infections. R Re es su ul lt ts s: : During the study period, 137 infection episodes were determined in 95 patients with a diagnosis of nosocomial infections according to the criteria of Centers for Disease Control (CDC). The infection rate was 38%. Urinary tract infection was the most common infection followed by pneumonia and bacteremia. All patients with urinary tract infection had urinary catheterization, 42.5% of the patients with pneumonia had mechanical ventilation and 68.4% with primary bacteremia had central intravenous catheterization. In these infections, 59.1% of the isolated pathogens were gram-negative bacilli, 38.6% were gram-positive bacteria and the remaining 2.1% were Candida spp. Escherichia coli, S. aureus, P. aeruginosa and coagulase-negative staphylococci were the most common pathogens identified. In urinary tract infections E. coli and in pneumonia and bacteremia S. aureus was the most common responsible pathogen. Among the gram-positive bacteria and gram-negative bacilli, high antimicrobial resistance was observed. Resistance to teicoplanin was 14.6% and linezolid was 11.1%, in S. aureus, whereas resistance to ciprofloxacin was 88.8% and vancomycin was 11.1% in Enterococcus spp. Imipenem was determined as the most effective agent against the isolated gram-negative bacteria, followed by cefepime, however, 16.6% of the Acinetobacter spp. and 17.6% of the P. aeruginosa were resistant to imipenem. C Co on nc cl lu us si io on n: : In order to prevent or reduce the nosocomial infections, surveillance methods must be carried out in intensive care units and in the entire hospital.K Ke ey y W Wo or rd ds s: : Intensive care units; cross infection; anti-bacterial agents Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmada, yoğun bakım ünitemizdeki nozokomiyal enfeksiyonların patojen tiplerini belirlemek ve antibiyotik duyarlılıklarını ölçmek amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Atatürk Eğitim ve Araştırma Hastanesi'nin Ocak 2007 tarihinde hizmete açılan 1. Dahiliye Kliniği Yoğun Bakım Ünitesinde, Ocak-Ekim 2007 tarihleri arasında toplam 250 hasta takip edildi. Bu hastalardan hastane enfeksiyonu tanısı alan 95 hasta için aktif, ileriye dönük, hasta ve laboratuar bulgularına dayalı sürveyans metodu kullanıldı. B Bu ul lg gu ul la ar r: : Çalışma sürecinde Hastalık Kontrol ve Önleme Merkezi (CDC) kriterlerine uygun olarak nozokomiyal enfeksiyon teşhisi konulan 95...

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Antimicrobial open‐cell polyurethane foams with quaternary ammonium salts

Demirci

Yıldırım

Kocer

2017

J of Applied Polymer Sci

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An hydroxyl‐terminated quaternary ammonium salt polymer (QAP) was added to a foam formulation in various amounts between 1 and 5 wt %. The structures of the produced foams and their QAP content were characterized by Fourier transform infrared and EDXRF analyses. A linear polymer of QAP with a diisocyanate was also synthesized to support our investigations. The morphological changes such as the cell size and the cell structure of the produced foams were observed with scanning electron microscopy. Thermogravimetric analysis and dynamic mechanical analysis analyses were applied to examine the thermal and thermomechanical properties of the produced foams. Relatively low amount of QAP‐added foams showed very similar structural and thermomechanical properties to the unmodified foams. In addition, while the unmodified foams did not show any antimicrobial activity, the QAP‐added foams provided significant inactivation against Staphylococcus aureus, yeast and mold at concentrations of about 102 and 103 CFU within 5 h of contact time. The results showed that the addition of minute amount of QAP can significantly improve the biocidal performance of the produced foams without deteriorating their structure. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45914.

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Daily antibiotic cost of nosocomial infections in a Turkish university hospital

Cited by 40 publications

References 22 publications

Analysis of Cost of Antimicrobial Therapy along with Cost of Concomitant Drug Therapy in Patients Admitted in Critical Care Unit (CCU) at Charitable Trust Hospital In India

Analysis of Cost of Antimicrobial Therapy along with Cost of Concomitant Drug Therapy in Patients Admitted in Critical Care Unit (CCU) at Charitable Trust Hospital In India

An Overall View on Nosocomial Infections in an Intensive Care Unit

Antimicrobial open‐cell polyurethane foams with quaternary ammonium salts

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