D.C. polarography for mebendazole analysis

Pinzauti, S.; Porta, E. La; Papeschi, G.

doi:10.1016/0731-7085(83)80031-4

Cited by 9 publications

(13 citation statements)

References 7 publications

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“…A potentiometric assay method for thioamides, cationic surfactants, and halogenide ions using an Ag-Ag disulfide electrode was described in [80]. Methimazole and propylthiouracil were titrated with 0.01 M Hg(OAc) 2 in 0.025 M borate buffer solution.…”

Section: Titrimetric and Electrotitrimetric Analysis Methodsmentioning

confidence: 99%

Analysis of thyrostatic heteroaromatic thioamides (review)

Dolinkin

Chernov’yants

2010

Pharm Chem J

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This review discusses methods widely used in pharmaceutical and clinical practice for the identification and assay of the thyrostatic agents imidazoline-2-thione and uracil-2-thiones. Sample preparation stages (solid-phase and liquid extraction from biological materials) are discussed, along with chemical modification of drug molecules. A scheme for a hypothetical model of the inhibitory action of thyrostatic agents on thyroid hormone biosynthesis is presented. The analytical characteristics of individual methods for assaying thyrostatic agents discussed in this review can be used in manufacturing at the quality control stage.

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Section: Titrimetric and Electrotitrimetric Analysis Methodsmentioning

confidence: 99%

Analysis of thyrostatic heteroaromatic thioamides (review)

Dolinkin

Chernov’yants

2010

Pharm Chem J

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“…Consequently, our data indicated that the rate-determining step in the electrocatalytic oxidation of thiamazole might be a one-electron transfer process. Combining the fact that identical numbers of protons and electrons were involved in the electrode process, we conclude that the electrochemical reaction of thiamazole at the MWCNT modified GCE might be realized through the oxidation of sulfhydryl groups in the molecule [11,13,14,23]:…”

Section: Electrode Reaction Mechanisms Of Thiamazolementioning

confidence: 99%

“…Numerous analytical techniques have been described for the determination of thiamazole, which include high-performance liquid chromatography-mass spectrometry (HPLC-MS) [3,4], gas chromatography-mass spectrometry (GC-MS) [5], HPLC with ultraviolet detection [6,7], flow-injection with chemiluminescence detection [8], resonance light scattering spectroscopy [9], fluorescence probe method [10], potentiometric and voltammetric [11], titrimetric [12], etc. Electrochemical strategies for determining thiamazole have also been tried either using a silver-silver sulphide solid state electrode [13] or a carbon paste electrode [14], showing limited success.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical determination of thiamazole at a multi-wall carbon nanotube modified glassy carbon electrode

2010

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A simple and convenient method is described for voltammetric determination of thiamazole, a commonly used anti-hyperthyroid drug, based on its electrochemical oxidation at a multi-wall carbon nanotube modified glassy carbon electrode. Under optimized conditions, the proposed method exhibited acceptable analytical performances in terms of linearity (over the concentration range from 1.0 9 10 -7 to 5.0 9 10 -4 mol L -1 , r = 0.9983), detection limit (3.0 9 10 -8 mol L -1 ) and reproducibility (RSD = 2.64%, n = 10, for 5.0 9 10 -5 mol L -1 thiamazole). To further validate its possible application, the method was used for the quantification of thiamazole in pharmaceutical formulations and biological fluids.

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“…Several different analytical methods for the determination of PTU and MTU have been described such as Polarography [3,4], conductometric titration [5], potentiometric titration [5][6][7] and spectrophotometry [8,9], but these methods can only be applied in pharmaceutical preparations due to their lower sensitivity or lack of selectivity. In biological fluids, they have been determined by liquid chromatography [10][11], radioimmunoassay [12] and gas-liquid chromatography [13].…”

Section: Introductionmentioning

confidence: 99%