Electrochemical determination of thiamazole at a multi-wall carbon nanotube modified glassy carbon electrode

Xia, Xi; Liang, Ming; Liu, Jie

doi:10.1007/s10800-010-0122-x

Cited by 22 publications

(14 citation statements)

References 21 publications

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“…Previous electrochemical research has demonstrated that thiamazole can be oxidized to form highly reductive radicals (Fig. 7, II) (15,26). The oxidation peak is~0.45 V, which is much lower than that of Ru(bpy) 3 2+ (~1.20 V) (27).…”

Section: +mentioning

confidence: 89%

Flow injection analysis of thiamazole based on strong Ru(bpy)₃²⁺ co‐reactant electrochemiluminescence

Kong

Jiang

et al. 2014

Luminescence

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Based on the strong electrochemiluminescence (ECL) reaction between thiamazole and tris(2,2'-bipyridine)ruthenium(II) (Ru(bpy)3 (2+) ), a sensitive, simple and rapid flow injection analysis method for the determination of thiamazole was developed. When a Pt working electrode was maintained at a potential of +1.50 V (vs Ag/AgCl) in pH 12.0 H3 PO4 -NaOH solution containing thiamazole and Ru(bpy)3 (2+) at a flow rate of 1.0 mL/min, a linear range of 2.0 × 10(-7) -1.0 × 10(-4) mol/L with a detection limit of 5.0 × 10(-8) mol/L was obtained for the detection of thiamazole. The method showed good reproducibility with a relative standard deviation (RSD) of 0.75%. The method has been successfully applied to the determination of thiamazole in spiked animal feeds. In addition, a co-reactant ECL mechanism was proposed for the thiamazole-Ru(bpy)3 (2+) system.

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Section: +mentioning

confidence: 89%

Flow injection analysis of thiamazole based on strong Ru(bpy)₃²⁺ co‐reactant electrochemiluminescence

Kong

Jiang

et al. 2014

Luminescence

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“…The ECL reactions of these drugs in the presence of Ru(bpy) 3 2+ probably include a similar neutral radical mechanism. All of the four TDs studied are sulfhydryl compounds, they are easily oxidized to form highly reducing radicals (labeled as RS·) . The oxidation peak potentials on a Pt disk electrode are ∼+0.25, ∼+0.8, ∼+0.45, and ∼+0.5 V for TAP, TU, PTU, and MTU, respectively .…”

Section: Resultsmentioning

confidence: 99%

Capillary electrophoresis coupled with electrochemiluminescence detection for the separation and determination of thyreostatic drugs in animal feed

Kong

Chen

et al. 2014

J. Sep. Science

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A rapid, simple, and practical method for the determination of four of the most used thyreostatic drugs (methimazole, 2-thiouracil, 6-methyl-2-thiouracil, and 6-propyl-2-thiouracil) using CE coupled to electrochemiluminescence detection has been established, based on the electrochemiluminescence enhancement of tris(2,2-bipyridyl)ruthenium(II) with these analytes. Parameters that affect separation and detection were optimized. Under the optimum experimental conditions, the four analytes could be well separated within 11 min at the separation voltage of 16 kV in a running solution containing 20 mM phosphate buffer (pH 9.0) and 1.0 × 10(-4) M Ru(bpy)(3)(2+), with a solution of 20 mM phosphate buffer (pH 12.0) containing 1.0 × 10(-4) M Ru(bpy)(3)(2+) in the electrochemiluminescence detection cell. The detection limits for methimazole, 6-methyl-2-thiouracil, 6-propyl-2-thiouracil, and 2-thiouracil were 0.1, 0.05, 0.05, and 0.01 μM, respectively. The proposed method was applied to analyze these drugs in spiked animal feed samples. The recoveries were 88.2∼99.0 and 86.4∼98.7% for the intraday and interday analyses, respectively. The RSDs were 2.7∼4.8 and 1.8∼5.0% for the intraday and interday analyses, respectively. The results demonstrate that the proposed method has promising applications in the detection of thyreostatic drugs in animal feeds.

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“…Electrochemical methods, due to their advantages such as high sensitivity, high speed, and low-cost have been used in pharmaceutical analysis for a long time. Analysis of MMZ has been done by using modified electrodes such as glassy carbon electrode modified with multi-walled carbon nanotubes (Xi et al, 2010), an electrode modified with acetylene black/chitosan film (Yazhen, 2011), and a carbon paste electrode modified with a cobalt Schiff base complex (Shahrokhian and Ghalkhani, 2008).…”

Section: Methimazole Mmzmentioning

confidence: 99%

Electrocatalytic determination of anti-hyperthyroid drug, methimazole, using a modified carbon-paste electrode

Jalali¹

2013

Afr. J. Pharm. Pharmacol.

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The preparation and electrochemical behavior of a carbon-paste electrode modified with an oxovanadium (IV) Schiff-base complex was studied. The modified electrode showed efficient catalysis in the electrochemical oxidation of methimazole (MMZ), an anti-hyperthyroid drug. The catalytic effect was observed for V III oxidation peak which was produced via disproportionation of V IV in acidic solution. The diffusion coefficient (D) of MMZ and the rate constant of catalytic reaction (k) were estimated by chronoamperometry. Determination of MMZ was carried out using differential pulse voltametry. A linear dynamic range of 9 × 10 -7 to 1 × 10 -4 M with a detection limit of 8 × 10 -7 M and a limit of quantitation of 2.6 × 10 -6 M was resulted for the drug. The relative standard deviation for determination of 20 μM of the drug was found to be 1.7%. The method was used for the quantitation of MMZ in pharmaceutical formulations successfully.

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Electrochemical determination of thiamazole at a multi-wall carbon nanotube modified glassy carbon electrode

Cited by 22 publications

References 21 publications

Flow injection analysis of thiamazole based on strong Ru(bpy)₃²⁺ co‐reactant electrochemiluminescence

Flow injection analysis of thiamazole based on strong Ru(bpy)₃²⁺ co‐reactant electrochemiluminescence

Capillary electrophoresis coupled with electrochemiluminescence detection for the separation and determination of thyreostatic drugs in animal feed

Electrocatalytic determination of anti-hyperthyroid drug, methimazole, using a modified carbon-paste electrode

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Electrochemical determination of thiamazole at a multi-wall carbon nanotube modified glassy carbon electrode

Cited by 22 publications

References 21 publications

Flow injection analysis of thiamazole based on strong Ru(bpy)32+ co‐reactant electrochemiluminescence

Flow injection analysis of thiamazole based on strong Ru(bpy)32+ co‐reactant electrochemiluminescence

Capillary electrophoresis coupled with electrochemiluminescence detection for the separation and determination of thyreostatic drugs in animal feed

Electrocatalytic determination of anti-hyperthyroid drug, methimazole, using a modified carbon-paste electrode

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Flow injection analysis of thiamazole based on strong Ru(bpy)₃²⁺ co‐reactant electrochemiluminescence

Flow injection analysis of thiamazole based on strong Ru(bpy)₃²⁺ co‐reactant electrochemiluminescence