Electrocatalytic determination of anti-hyperthyroid drug, methimazole, using a modified carbon-paste electrode

Jalali, Fahimeh

doi:10.5897/ajpp12.717

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…Therefore, chemically modified electrodes have been frequently documented for the sensitive and selective determination of MMI. Acetylene black/chitosan film [ 17 ], MWCNTs [ 18 ], MWCNTs/electro-copolymerized cobalt nanoparticle–poly (pivalic acid) composite film [ 19 ], and carbon paste electrodes modified with Schiff base complexes of vanadium and cobalt [ 20 , 21 ], nanocomposite of CdS NP–RGO/IL [ 22 ], and MWCNT–titanium dioxide nanoparticles [ 23 ] are among the modifiers. In several applications mentioned, time was wasted in the modification and pretreatment steps.…”

Section: Introductionmentioning

confidence: 99%

A simple and fast flow injection amperometry for the determination of methimazole in pharmaceutical preparations using an unmodified boron-doped diamond electrode

et al. 2023

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In this work, an automated flow injection analysis (FIA) connected to a boron-doped diamond electrode (BDDE) was originally developed for the analysis of methimazole in pharmaceutical preparations. At a modification-free BDDE, methimazole was easilly oxidized. For the analysis of the mechanisms occurring at the electrode surface, cyclic voltammetry was employed to evaluate the impact of fundamental experimental parameters, such as pH and scan rate, on the BDDE response. For the quantitative detection, the FIA amperometric approach was constructed and used as a fast and sensitive method. The suggested approach provided a broad linear range of 0.5–50 µmol/L and a low detection limit of 10 nmol/L (signal-to-noise ratio = 3). Furthermore, the BDDE was successfully utilized to quantify methimazole in genuine samples from a variety of medicines, and its performance remained steady after more than 50 tests. The findings of amperometric measurements exhibit excellent repeatability, with relative standard deviations of less than 3.9 and 4.7 % for intra-day and inter-day, respectively. The findings indicated that, compared with traditional approaches, the suggested method has the following advantages: quick analysis time, simplicity, highly sensitive output, and no need for complicated operational processes.

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Section: Introductionmentioning

confidence: 99%

A simple and fast flow injection amperometry for the determination of methimazole in pharmaceutical preparations using an unmodified boron-doped diamond electrode

et al. 2023

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“…Various methods based on different analytical procedures have been described in literature for the determination of methimazole including Ultraviolet-Visible (UV-Vis) spectrophotometry [2][3][4][5][6][7], derivative spectrophotometry [8], Raman spectroscopy [9,10], resonance light scattering spectroscopy [11], chemiluminescence [12][13][14], fluorescence [15,16], capillary electrophoresis [17], immunoassay [18], molecularly imprinted biomimetic sensing [19], Thin Layer Chromatography (TLC) [20] and High Performance Liquid Chromatography (HPLC) [21][22][23][24][25]. Methimazole has been also determined using electrochemical methods by using different chemically modified electrodes through introducing various electron mediators on its surface [26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Novel Selective Spectrophotometric Methods for the Determination of Methimazole in Pure Form and in Pharmaceutical Formulation

Bathish

Gazy

Jamal

2019

Int J Pharm Pharm Sci

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Objective: To develop and validate new, selective spectrophotometric colorimetric analytical methods for the quantification of methimazole in its pure form and in its pharmaceutical preparations. Methods: Method A is based on the oxidation of methimazole with potassium permanganate in alkaline medium, the manganate ion produced was measured at λmax= 610 nm. Method B is a kinetic determination of methimazole using fixed-time method based on the oxidation of methimazole using known excess of cerium (IV) nitrate in acidic medium and assessing the unreacted Ce (IV) by adding a fixed amount of methyl orange and measuring the absorbance of the resultant solution at λmax=507 nm which is equivalent to the unreacted methyl orange. The reaction conditions and analytical parameters are investigated and optimized. Method validation was carried out according to ICH guidelines in terms of linearity, LOD, LOQ, precision, and accuracy. Results: Beer’s law is obeyed in the range of 1.50–15.00 μg/ml for method A and 0.25–3.00 μg/ml for method B. The developed methods were subjected to the detailed validation procedure. The proposed spectrophotometric methods were applied for the determination of the methimazole in its pure form and in its pharmaceutical formulation. The percentage recoveries were found to be 100.82 % and 99.85 % in the pharmaceutical formulation for the two proposed methods, respectively. Conclusion: Both developed spectrophotometric methods, considered as green analytical chemistry, were found to be novel, highly selective and can be applied for the quality control of methimazole in its pure form and in its pharmaceutical formulation based on the simplicity, applicability of the parameters, accessibility of the reagents employed and reasonably low time of analysis.

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“…The catalytic efficiency and other characteristics of oxovanadium(IV) compounds depend on the nature of ligand, coordination number, and stereochemistry [6]. VO 2+ -S is already used for the electrocatalytic oxidation and subsequent determination of pyridoxine [7], ascorbic acid [8], sulphide [9], cysteine [6], and other analytes [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Electrocatalytic Oxidation and Determination of Cysteine at Oxovanadium(IV) Salen Coated Electrodes

Sonkar

Ganesan

Rao

2014

International Journal of Electrochemistry

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A transition metal complex, oxovanadium(IV) salen (where salen represents N,N -bis(salicylidene)ethylenediamine) is immobilized on glassy carbon (GC) electrodes and utilized for electrocatalytic oxidation of cysteine. In presence of oxovanadium(IV) salen, increased oxidation current is observed due to the effective oxidation of cysteine by the electrogenerated oxovanadium(V) salen species. The oxidation current linearly varies with the concentration of cysteine from 0.1 to 1.0 mM. The modified electrode has good sensitivity and low limit of detection. These properties make the oxovanadium(IV) salen as an effective electrocatalyst for the determination of cysteine.

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Electrocatalytic determination of anti-hyperthyroid drug, methimazole, using a modified carbon-paste electrode

Cited by 7 publications

References 17 publications

A simple and fast flow injection amperometry for the determination of methimazole in pharmaceutical preparations using an unmodified boron-doped diamond electrode

A simple and fast flow injection amperometry for the determination of methimazole in pharmaceutical preparations using an unmodified boron-doped diamond electrode

Novel Selective Spectrophotometric Methods for the Determination of Methimazole in Pure Form and in Pharmaceutical Formulation

Electrocatalytic Oxidation and Determination of Cysteine at Oxovanadium(IV) Salen Coated Electrodes

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