Cytotoxicity of naturally occurring rhamnofolane diterpenes from Jatropha curcas

Three new compounds, including two diterpenoids, nemoralisins H and I (1 and 2), and a limonoid, 2-methoxy khayseneganin E (3), along with four known constituents (4–7), were isolated from the leaves and twigs of Swietenia mahagoni. Their chemical structures were elucidated by means of spectroscopic analysis. The cytotoxities of these isolated constituents were assayed.Electronic supplementary materialThe online version of this article (doi:10.1007/s13659-014-0006-6) contains supplementary material, which is available to authorized users.

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“…The cytotoxic activities of compounds 1 – 7 against HL-60, SMMC-7721, A549, MCF-7 and SW480 cell lines were determined by the MTT method [21]. …”

Section: Experiments Sectionmentioning

confidence: 99%

Diterpenoids and Limonoids from the Leaves and Twigs of Swietenia mahagoni

Zhang

Liu

Deng

et al. 2014

Nat. Prod. Bioprospect.

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“…Recently, a series of secondary metabolites with fascinating structural features and significant biological activities from Euphorbiaceae family were reported by our group and others (Gao et al, 2007;Li et al, 2011;Tang et al, 2012a,b;Liu et al, 2013). Manihot (Euphorbiaceae) contains about 60 species widely distributed in tropical regions.…”

Section: Introductionmentioning

confidence: 97%

Two new pentacyclic triterpenoids from the stems of Manihot esculenta

Yamei

Zou

Chen

et al. 2015

Phytochemistry Letters

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“…Recently, a series of secondary metabolites with fascinating structural features and significant biological activities from Euphorbiaceae family were reported. The main constitutes of Euphorbiaceae are diterpenoids with different skeletons such as jatrophanes, lathyranes, tiglianes, ingenanes, and myrsinanes with a wide array of pharmaceutical activities, such as antiproliferative, cytotoxic, antimicrobial and anti-inflammatory, anticancer and antioxidant activities [1–7]. Manihot (Euphorbiaceae), a shrub, has about 60 species and is widely cultivated in tropical regions.…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents from the Stems of Manihot esculenta

Yamei

Wang

Chen

et al. 2015

Nat. Prod. Bioprospect.

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Two new compounds, maniesculentins A (1) and B (6), together with four known ones were isolated from the stems of Manihot esculenta Crantz. The structures of the new compounds were elucidated by extensive spectroscopic methods including NMR spectroscopy and mass spectrometry. The two new compounds (1, 6) were assayed for antibacterial activity against four tested bacteria lines.Graphical AbstractElectronic supplementary materialThe online version of this article (doi:10.1007/s13659-015-0052-8) contains supplementary material, which is available to authorized users.

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Cytotoxicity of naturally occurring rhamnofolane diterpenes from Jatropha curcas

Cited by 52 publications

References 16 publications

Diterpenoids and Limonoids from the Leaves and Twigs of Swietenia mahagoni

Diterpenoids and Limonoids from the Leaves and Twigs of Swietenia mahagoni

Two new pentacyclic triterpenoids from the stems of Manihot esculenta

Chemical Constituents from the Stems of Manihot esculenta

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