Cytotoxicity and apoptosis induction by Fumaria officinalis extracts in leukemia and multiple myeloma cell lines

Adham, Aveen Nozad; Naqishbandi, Alaadin M.; Efferth, Thomas

doi:10.1016/j.jep.2020.113458

Cited by 21 publications

(17 citation statements)

References 42 publications

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“…Fumitori (Fumaria officinalis L.) is an annual leafy plant used in the Kurdish and Europe ethnobotany for treatment of hepatobiliary dysfunction, gastrointestinal diseases, diuretic agents, cancer and skin disorders [419]. It contains some antiangiogenic phytochemicals previously described in this review, such as rosmarinic acid, quercetin and kaempferol, among others [420], but probably most of the angiopreventive potential of this plant derives from its content of fumaric acid esters. Dimethylfumarate exhibits interesting antiangiogenic properties, being able to interfere with certain functions of endothelial cells, including differentiation, proliferation, and migration.…”

Section: Herbs and Spicesmentioning

confidence: 95%

Angioprevention of Urologic Cancers by Plant-Derived Foods

et al. 2022

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The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney tumors, are no exceptions to this rule. Moreover, the fact that many of these tumors are detected in early stages lengthens the duration of their treatment, with a significant increase in health care costs. In this scenario, prevention offers the most cost-effective long-term strategy for the global control of these diseases. Although specialized diets are not the only way to decrease the chances to develop cancer, epidemiological evidence support the role of certain plant-derived foods in the prevention of urologic cancer. In many cases, these plants are rich in antiangiogenic phytochemicals, which could be responsible for their protective or angiopreventive properties. Angiogenesis inhibition may contribute to slow down the progression of the tumor at very different stages and, for this reason, angiopreventive strategies could be implemented at different levels of chemoprevention, depending on the targeted population. In this review, epidemiological evidence supporting the role of certain plant-derived foods in urologic cancer prevention are presented, with particular emphasis on their content in bioactive phytochemicals that could be used in the angioprevention of cancer.

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Section: Herbs and Spicesmentioning

confidence: 95%

Angioprevention of Urologic Cancers by Plant-Derived Foods

et al. 2022

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“…This is a general property of the green synthesized metallic nanoparticles, that was found in our literature review [17,[22][23][24]. In our review of literature, the size of silver nanoparticles, which were synthesized using plant extract was in the range of 5 to 251.1 nm [9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: P R E P R I N Tmentioning

confidence: 99%

“…Due to the antibacterial properties of these metal oxide nanoparticles, they can be used in the food industry and active food packaging. Also, metallic nanoparticles are potentially used in hyperthermia, magnetic resonance imaging (MRI), diagnosis and treatment of tumors or cancer, biomarkers, biodegradation, biotechnology and the removal of important organic, inorganic and radioactive contaminants due to their high biocompatibility [8][9][10][11][12][13][14]. Metallic nanoparticles have many applications in various fields such as fuel cells (hydrogen, methanol), glucose detection, drug delivery, toxicology, and biological interactions [10,11].…”

Section: Introductionmentioning

confidence: 99%

Calendula officinalis green-mediated silver nanoparticles: Formulation, characterization and assessment of colorectal cancer activities green-mediated silver nanoparticles.

Mahdavi

Zangeneh

et al. 2021

Arch Med Sci

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IntroductionThe biosynthesis of metal nanoparticles using medicinal plants is not only economical but also environmentally friendly as well as having miscellaneous biomedical applications. In the present study, silver nanoparticles were green-synthesized using the aqueous extract of Calendula officinalis.Material and methodsThe synthesized AgNPs@Calendula officinalis were characterized by analytical techniques including EDX, FE-SEM, XRD, UV-Vis., and FT-IR. The anti-human colorectal cancer activities of AgNPs@Calendula officinalis were evaluated using MTT assay.ResultsThe nanoparticles were formed in a spherical shape in the range of 38.05 to 75.41 nm for the particle size. On the other hand, the MTT assay was run to evaluate anti colorectal cancer activity of AgNPs@Calendula officinalis. In the cellular and molecular part of the recent study, the treated cells with AgNPs@Calendula officinalis were assessed by MTT assay for 48 h about the cytotoxicity and anti-human colorectal carcinoma properties on normal (HUVEC) and colorectal carcinoma cell lines i.e. WiDr, SW1417 [SW-1417], and DLD-1. In the antioxidant test, the IC50 of AgNPs@Calendula officinalis and BHT against DPPH free radicals were 222 and 124 µg/mL, respectively. The viability of malignant colorectal cell line reduced dose-dependently in the presence of AgNPs@Calendula officinalis. The IC50 of AgNPs@Calendula officinalis were 430, 326, and 392 µg/mL against WiDr, SW1417 [SW-1417], and DLD-1 cell lines, respectively.ConclusionsAfter the clinical study, silver nanoparticles containing Calendula officinalis leaf aqueous extract may be used to formulate a new chemotherapeutic drug or supplement to treat the several types of human colorectal carcinoma.

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“…Fumitory or Fumaria officinalis is an annual plant. The plant belongs to the family of Fumariaceae [7]. Fumaria officinalis comprises various secondary metabolites such as polyphenolic compounds (caffeic acid, rosmarinic acid), flavonoids compounds (isoquercitrinquercitrin, quercetin, rutin, kaempferol), and alkaloids compounds (protopine, cryptopine, stylopine, N-methylsinactine, fumaritine, fumariline), saponins, carbohydrates, glycosides, and tannins [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Fumaria officinalis comprises various secondary metabolites such as polyphenolic compounds (caffeic acid, rosmarinic acid), flavonoids compounds (isoquercitrinquercitrin, quercetin, rutin, kaempferol), and alkaloids compounds (protopine, cryptopine, stylopine, N-methylsinactine, fumaritine, fumariline), saponins, carbohydrates, glycosides, and tannins [8][9][10][11]. The plant is known as a popular medicinal plant in different traditional medicine worldwide [7,10]. Fumaria officinalis is used as an agent to cure hepatobiliary dysfunction, gastrointestinal diseases, diuretic problems, cancer, and skin disorders [12,13].…”

Section: Introductionmentioning

confidence: 99%

Characterization and anti-acute myeloid leukemia and anti-acute T cell leukemia properties of zinc nanoparticles synthesized by a green approach for bioremediation applications

2021

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IntroductionEvery year, many people die due to cancer in all of the world. So, the preparation and formulation of new chemotherapeutic supplements and drugs with remarkable effects to treat cancer are the priority of both developing and developed countries. In this study, zinc nanoparticles were synthesized in an aqueous medium using Fumaria officinalis leaf as stabilizing and reducing agents.Material and methodsThe green synthesized ZnNPs@ Fumaria officinalis were characterized using different techniques including UV-visible and FT-IR spectroscopy, X‐ray diffraction (XRD), scanning electron microscopy (SEM), and Energy Dispersive X-ray Spectrometry (EDS). The anticancer activity of ZnNPs@ Fumaria officinalis was evaluated against acute myeloid leukemia and acute T cell leukemia.ResultsAccording to the XRD analysis, 20.44 nm was measured for the crystal size of the nanoparticles. SEM images showed a uniform spherical morphology with an average size of 27.96 nm for ZnNPs@ Fumaria officinalis. In the cellular and molecular part of the recent study, the treated cells with ZnNPs@Fumaria officinalis were assessed by MTT assay for 48h about the cytotoxicity and anti-human acute leukemia properties on normal (HUVEC), acute myeloid leukemia (32D-FLT3-ITD and Human HL-60/vcr), and acute T cell leukemia (Jurkat, Clone E6-1 and J.RT3-T3.5) cell lines. The IC50 of ZnNPs@Fumaria officinalis were 227, 200, 250, and 336 µg/mL against 32D-FLT3-ITD, Human HL-60/vcr, Jurkat, Clone E6-1, and J.RT3-T3.5 cell lines, respectively.ConclusionsThe viability of malignant leukemia cell line reduced dose-dependently in the presence of ZnNPs@Fumaria officinalis. It appears that the anti-human acute leukemia effect of ZnNPs@Fumaria officinalis is due to their antioxidant effects.

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Cytotoxicity and apoptosis induction by Fumaria officinalis extracts in leukemia and multiple myeloma cell lines

Cited by 21 publications

References 42 publications

Angioprevention of Urologic Cancers by Plant-Derived Foods

Angioprevention of Urologic Cancers by Plant-Derived Foods

Calendula officinalis green-mediated silver nanoparticles: Formulation, characterization and assessment of colorectal cancer activities green-mediated silver nanoparticles.

Characterization and anti-acute myeloid leukemia and anti-acute T cell leukemia properties of zinc nanoparticles synthesized by a green approach for bioremediation applications

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