Characterization and anti-acute myeloid leukemia and anti-acute T cell leukemia properties of zinc nanoparticles synthesized by a green approach for bioremediation applications

Abstract

IntroductionEvery year, many people die due to cancer in all of the world. So, the preparation and formulation of new chemotherapeutic supplements and drugs with remarkable effects to treat cancer are the priority of both developing and developed countries. In this study, zinc nanoparticles were synthesized in an aqueous medium using Fumaria officinalis leaf as stabilizing and reducing agents.Material and methodsThe green synthesized ZnNPs@ Fumaria officinalis were characterized using different techniques including UV-visible and FT-IR spectroscopy, X‐ray diffraction (XRD), scanning electron microscopy (SEM), and Energy Dispersive X-ray Spectrometry (EDS). The anticancer activity of ZnNPs@ Fumaria officinalis was evaluated against acute myeloid leukemia and acute T cell leukemia.ResultsAccording to the XRD analysis, 20.44 nm was measured for the crystal size of the nanoparticles. SEM images showed a uniform spherical morphology with an average size of 27.96 nm for ZnNPs@ Fumaria officinalis. In the cellular and molecular part of the recent study, the treated cells with ZnNPs@Fumaria officinalis were assessed by MTT assay for 48h about the cytotoxicity and anti-human acute leukemia properties on normal (HUVEC), acute myeloid leukemia (32D-FLT3-ITD and Human HL-60/vcr), and acute T cell leukemia (Jurkat, Clone E6-1 and J.RT3-T3.5) cell lines. The IC50 of ZnNPs@Fumaria officinalis were 227, 200, 250, and 336 µg/mL against 32D-FLT3-ITD, Human HL-60/vcr, Jurkat, Clone E6-1, and J.RT3-T3.5 cell lines, respectively.ConclusionsThe viability of malignant leukemia cell line reduced dose-dependently in the presence of ZnNPs@Fumaria officinalis. It appears that the anti-human acute leukemia effect of ZnNPs@Fumaria officinalis is due to their antioxidant effects.

Influence of Carbohydrates Covalently Bonded with Lignin on Solvent Fractionation, Thermal Properties, and Nanoparticle Formation of Lignin

“…Up to now, various (aqueous) solvents, ethanol, methanol, acetone, THF, dioxane, DMSO, etc., have been applied for lignin dissolution for lignin nanoparticles preparation. ,− However, acetone, especially its aqueous solution, has been demonstrated to be an excellent solvent due to it being more environmentally friendly and having an increased ability to dissolve lignin and a unique ability to form uniform LGNPs by nanopricipitation . Thus, in this study, aqueous acetone (75 wt %) was used as a solvent for the higher carbohydrate content fractions that cannot be dissolved in anhydrous acetone.…”

In VitroAnticancer Activity of the Light Stable Zinc Isotope (64Zn) Compounds

“…Moreover, patients with late-stage disease had ANTICANCER RESEARCH 42: 5685-5698 (2022) significantly lower zinc concentration in their lymphocytes than early-stage patients (23). An in vitro study conducted by Zou et al on the antitumor activity of zinc nanoparticles against myeloid and T-cell leukemia cells showed that zinc nanoparticles were able to suppress the viability of malignant cells in a dose-dependent manner (24).…”