Cytotoxic Triterpenoids from the Barks of Betula platyphylla var. japonica

Abstract

Phytochemical investigation on the barks of Betula platyphylla var. japonica (Betulaceae) was carried out, resulting in the isolation and identification of three new triterpenoids, 27-O-cis-caffeoylcylicodiscic acid (1), 27-O-cis-feruloylcylicodiscic acid (2), and 27-O-cis-caffeoylmyricerol (3), along with six known triterpenoids, obtusilinin (4), winchic acid (5), 27-O-trans-caffeoylcylicodiscic acid (6), uncarinic acid E (7), myriceric acid B (8), and 3-O-trans-caffeoyloleanolic acid (9). The structures of the new compounds were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS. All of the isolated compounds were evaluated for cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and Bt549). Compounds 2, 6, 8, and 9 exhibited potent cytotoxicity against all of the tumor cells tested (IC < 10.0 μm), while compounds 3, 4, 5, and 7 showed moderate cytotoxicity against all of the tumor cells tested (IC < 20.0 μm).

The effects of phenolic glycosides from Betula platyphylla var. japonica on adipocyte differentiation and mature adipocyte metabolism

“…As the main components of the bark of B. platyphylla var. japonica , triterpenoids were also identified from the source in our recent studies 8 , 9 , where the chemical characterization of antioxidant triterpenoids combined with phenylpropanoid unit as well as cytotoxic triterpenoids against several human tumor cells were reported 8 , 9 . Despite repetitive reports of the identification of triterpenoids from B. platyphylla var.…”

Production of triterpenoid compounds fromGanoderma lucidumspore powder using ultrasound-assisted extraction

“…The fruiting body, mycelia and spores of G. lucidum have traditionally been used for preventing and treating various medical conditions including, but not limited to, hepatitis [3], hypertension [4], nephritis [5], bronchitis [5] and some cancers [6]. The chemical composition of G. lucidum is very complicated; containing 11 active substances including polysaccharides, organic germanium, triterpenoids, oils, inorganic ions and sterols [7].…”