Biological Evaluation of a New Lignan from the Roots of Rice (Oryza sativa)

Abstract

LC/MS-based phytochemical analysis of an EtOH extract of the roots of rice (Oryza sativa; Gramineae), which takes a crucial role in the stable crop population in Asia, resulted in the isolation of a new lignan, oryzativol C (1), as a minor component. The chemical structure of compound 1 was unambiguously confirmed using spectroscopic evidence (including 1D- and 2D-NMR data), HR-ESI-MS, and CD data analysis. Considering the traditional medicinal efficacy of O. sativa and its importance as a food crop, compound 1 was evaluated for effects on breast cancer cell lines (MDA-MB-231) and on glucose-stimulated insulin secretion in an INS-1 pancreatic β-cell line. Compound 1 showed mild cytotoxicity toward the MDA-MB-231. Furthermore, compound 1 stimulated insulin secretion in INS-1 pancreatic β-cells without inducing cytotoxicity. These results indicate that compound 1 is an active ingredient of O. sativa that offers health benefits including inhibition of breast cancer cell proliferation and hyperglycemia control.

α‐glucosidase, α‐amylase inhibitory potential and antioxidant activity of fragrant black rice (Thai coloured rice)

“…The extract of black sticky rice ( Oryza sativa L) combined with dill has improved poststroke cognitive impairment in metabolic syndrome condition 9 . Lee et al 10 showed that the purified compound from black rice ( O sativa L) had the inhibitory activity on breast cancer cell proliferation and hyperglycaemia. Zhao et al 11 also showed protection against DSS‐induced colitis in mice by black rice anthocyanin‐rich extract.…”