The effects of phenolic glycosides from <i>Betula platyphylla</i> var. <i>japonica</i> on adipocyte differentiation and mature adipocyte metabolism

Moon

Chemistry & Biodiversity

et al. 2019

Catechins in green tea are well‐known to be effective in reducing the risk of obesity. The purpose of this study was to elucidate the effects of catechins present in green tea on adipocyte differentiation and mature adipocyte metabolism. Treatment of 3T3‐L1 mouse adipocyte during differentiation adipocytes with (−)‐epigallocatechin (EGC) and gallic acid (GA) resulted in dose‐dependent inhibition of adipogenesis. Specifically, EGC increased adiponectin and uncoupling protein 1 (UCP1) transcription in mature adipocytes. Transcription levels of adipose triglyceride lipase (ATGL) and hormone‐sensitive lipase (HSL) were not significantly impacted by either of the compounds. These results suggest that the EGC is the most effective catechin having anti‐obesity activity. Finally, EGC is an attractive candidate component for remodeling obesity.

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epigallocatechin Exerts Anti‐Obesity Effect in Brown Adipose Tissue

Moon

Chemistry & Biodiversity

et al. 2019

“…Previous studies investigating the anti-cancer effect of platyphyllenone have shown that the compound is capable of inhibiting the proliferation of human breast and lung cancer cells [ 13 , 19 ]. However, in these previous studies, very high concentrations of platyphyllenone (25 µM and 50 µM) were used to investigateits cytotoxic effects.…”

Section: Discussionmentioning

confidence: 99%

PlatyphyllenoneExerts Anti-Metastatic Effects on Human Oral Cancer Cells by Modulating Cathepsin L Expression, MAPK Pathway and Epithelial–Mesenchymal Transition

Velmurugan

Lin

Mahalakshmi³

et al. 2021

IJMS

Advanced-stage oral cancers with lymph node metastasis are associated with poor prognosis and a high mortality rate. Although recent advancement in cancer treatment has effectively improved the oral cancer prognosis, the majority of therapeutic interventions are highly expensive and are associated with severe sideeffects. In the present study, we studied the efficacy of a diarylheptanoid derivative, platyphyllenone, in modulating the metastatic potential of human oral cancer cells. Specifically, we treated the human oral cancer cells (FaDu, Ca9-22, and HSC3) with different concentrations of platyphyllenone and measured the cell proliferation, migration, and invasion. The study findings revealed that platyphyllenonesignificantly inhibited the motility, migration, and invasion of human oral cancer cells. Mechanistically, platyphyllenone reduced p38 phosphorylation, decreased β-catenin and Slug, increased E-cadherin expression, and reduced cathepsin L expression, which collectively led to a reduction in cancer cell migration and invasion. Taken together, our study indicates that platyphyllenone exerts significant anti-metastatic effects on oral cancer cells by modulating cathepsin L expression, the MAPK signaling pathway, and the epithelial–mesenchymal transition process.

Bioscience, Biotechnology, and Biochemistry

“…adipocytes yielded Eurycoma longifolia Jack [70]. Two quassinoids from this plant, polymethoxyflavones [72][73][74], pterostilbene [75], arylbutanoid glycosides [76], aculeatin [77], (3, 3-dimethylallyl)halfordinol [78], and arecoline [79]. However, although knowledge of plants containing pro-lipolytic compounds is gradually increasing, the exact mechanisms of action involved require clarification.…”

Section: Screening Of Medicinal Plants For Candidates That Reduce Lipmentioning

confidence: 99%

Bioactive compounds in plant materials for the prevention of diabetesand obesity

Kato

2019

Plant materials have been widely studied for their preventive and therapeutic effects for type 2 diabetes mellitus (T2DM) and obesity. The effect of a plant material arises from its constituents, and the study of these bioactive compounds is important to achieve a deeper understanding of its effect at the molecular level. In particular, the study of the effects of such bioactive compounds on various biological processes, from digestion to cellular responses, is required to fully understand the overall effects of plant materials in these health contexts. In this review, I summarize the bioactive compounds we have recently studied in our research group that target digestive enzymes, dipeptidyl peptidase-4, myocyte glucose uptake, and lipid accumulation in adipocytes.