Cytotoxic effects of essential oils from four Lippia alba chemotypes in human liver and lung cancer cell lines

Nanocapsules containing Saussurea lappa essential oil: Formulation, characterization, antidiabetic, anti-cholinesterase and anti-inflammatory potentials

“…They found that the EO reduced cells viability in a concentration and timedependent manner. Similar results were also reported in the literature (Montero-Villegas et al, 2018). Moreover, the encapsulated -EO is more cytotoxic than its un-encapsulated form (especially at higher concentration) which can be attributed to the nanoencapsulation concept.…”

In Vitro and in Silico Assessment of the Potential of Niaouli Essential Oil as a Quorum Sensing Inhibitor of Biofilm Formation and its Effects on Fibroblast Cell Viability

“…Plant-derived compounds are very precious sources for the discovery of potent bioactive molecules that are potential drugs [1][2][3]. Compounds of medicinal plants, especially essential oils (EOs), have been used for their antioxidative, anti-inflammatory and antibacterial properties [3].…”

New Chemovariety ofLippia albaFrom Colombia: Compositional Analysis of the Volatile Secondary Metabolites and Somein vitroBiological Activities of the Essential Oil From Plant Leaves

“…The literature analysis about the cytotoxicity of the EO of different chemo-varieties from L. alba showed that some EO exhibited effects against cell lines, eg, citral and carvone chemotypes were cytotoxic against HeLa line [CC 50 (50% cytotoxic concentration, µg/mL): 3. [48][49][50][51] For comparative purposes, some reports of plant EO con- ; Dysphania ambrosioides EO rich in cis-piperitone oxide (~35%) reduced the viability of GM07492-A line (IC 50 : 207 ± 4 µg/mL). Besides, Minthostachys mollis EO (~30% cis-piperitone oxide) was cytotoxic against Vero cells (CC 50 < 25 µg/mL).…”

“…The literature analysis about the cytotoxicity of the EO of different chemo-varieties from L. alba showed that some EO exhibited effects against cell lines, eg, citral and carvone chemotypes were cytotoxic against HeLa line [CC 50 (50% cytotoxic concentration, µg/mL): 3. [48][49][50][51] For comparative purposes, some reports of plant EO containing cis-/trans-piperitone oxides (as major component) and assessment of cytotoxicity were selected. Thus, EO from Mentha, M. mozaffarianii, composed of piperitone oxide (~33% ± 1%-51.5% ± 0.6%), presented high cytotoxicity on MOLT-4 line [IC 50 (µg/mL): ~22 ± 5-26 ± 2]; M. longifolia EO constituted by piperitone oxide (~40% ± 1%-65% ± 2%) were active against MCF-7 [IC 50 (µg/mL): ~45 ± 2-51 ± 2] and LN-CaP cells [IC 50 (µg/mL): ~44 ± 2-52 ± 3]; Dysphania ambrosioides EO rich in cis-piperitone oxide (~35%) reduced the viability of GM07492-A line (IC 50 : 207 ± 4 µg/mL).…”

“…The literature analysis about the cytotoxicity of the EO of different chemo-varieties from L. alba showed that some EO exhibited effects against cell lines, eg, citral and carvone chemotypes were cytotoxic against HeLa line [CC 50 (50% cytotoxic concentration, µg/mL): 3.5 ± 0.7 and 74 ± 7, respectively] and Vero cells (LC 50 : ~31-48 µg/mL); citral chemotype was effective on K562 cells [IC 50 (µg/mL): 13.0 ± 0.1-37 ± 1] and Vero cells [CC 50 (µg/mL): 65 ± 3-142 ± 1]; carvone, piperitone, ocimenone, and citral chemotypes were active against HepG2 cells [IC 50 (µg/mL): ~34 ± 3-412 ± 31], A549 line [IC 50 (µg/mL): ~30 ± 3-304 ± 24] and Vero cells [IC 50 (µg/mL): ~89 ± 9-592 ± 42]. 48 -51…”