Nanocapsules containing Saussurea lappa essential oil: Formulation, characterization, antidiabetic, anti-cholinesterase and anti-inflammatory potentials

Lammari, Narimane; Demautis, Tanguy; Louaer, Ouahida; Meniai, Abdeslam Hassen; Casabianca, Hervé; Bensouici, Chawki; Devouassoux, Gilles; Fessi, Hatem; Bentaher, Abderrazzak; Elaı̈ssari, Abdelhamid

doi:10.1016/j.ijpharm.2020.120138

Cited by 40 publications

(16 citation statements)

References 109 publications

(122 reference statements)

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“…Saussurea costus EO from commercial Algerian roots, obtained by SFE, was characterized by 21 identified compounds, accounting for 82.8% of the total oil. DEH was identified as the principal component (55.4%), followed by COS (8.9%), dehydrosaussurea lactone (6.6%), and aplotaxene (4.7%) [ 277 ].…”

Section: Essential Oils From Selected Rootsmentioning

confidence: 99%

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Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Lunz

Stappen

2021

Molecules

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Since ancient times, plant roots have been widely used in traditional medicine for treating various ailments and diseases due to their beneficial effects. A large number of studies have demonstrated that—besides their aromatic properties—their biological activity can often be attributed to volatile constituents. This review provides a comprehensive overview of investigations into the chemical composition of essential oils and volatile components obtained from selected aromatic roots, including Angelica archangelica, Armoracia rusticana, Carlina sp., Chrysopogon zizanioides, Coleus forskohlii, Inula helenium, Sassafras albidum, Saussurea costus, and Valeriana officinalis. Additionally, their most important associated biological impacts are reported, such as anticarcinogenic, antimicrobial, antioxidant, pesticidal, and other miscellaneous properties. Various literature and electronic databases—including PubMed, ScienceDirect, Springer, Scopus, Google Scholar, and Wiley—were screened and data was obtained accordingly. The results indicate the promising properties of root-essential oils and their potential as a source for natural biologically active products for flavor, pharmaceutical, agricultural, and fragrance industries. However, more research is required to further establish the mechanism of action mediating these bioactivities as well as essential oil standardization because the chemical composition often strongly varies depending on external factors.

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Section: Essential Oils From Selected Rootsmentioning

confidence: 99%

“…Moreover, a strong antidiabetic effect, with IC 50 = 22.9 and 75.8 μg/mL against α-amylase and α-glucosidase, respectively, could be shown. No cytotoxic effect at 25 μg/mL was observed [ 277 ].…”

Section: Essential Oils From Selected Rootsmentioning

confidence: 99%

Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Lunz

Stappen

2021

Molecules

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“…Moreover; the determined of MIC by ethanol extract of S. costus which ranged between 2 and 8 µg/ml Saussurea lappa extracted by ethanol as antibacterial effect on Helicobacter pylori [23]. Lammari et al[52] identified compounds by GC/MS in Saussurea lappa (known as costus) that a significant effect of biological interests include( βeudesmol, a sesquiterpene). Moreover, recently this compound was shown as an effective inhibitor of SARS-CoV-2 main protease [53].…”

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confidence: 99%

Antimicrobial activity of bioactive compounds extract from Saussurea costus against food spoilage microorganisms

Deabes¹,

Fatah

Salem

et al. 2021

Egypt. J. Chem.

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Saussurea costus had a wide range of antimicrobial activities which used as alternative for synthetic preservatives that threaten human health. This study aimed to identify the bioactive compounds in S. costus extract (SCE) and to evaluate its antimicrobial activity against some pathogenic microorganisms. HPLC and GC-MS were used to quantify the bioactive compounds in SCE. The results indicated that ethanol and ethyl acetate extracts had the highest levels of polyphenols followed by n-butanol, and then n-hexane extracts. The main phenolic compounds are Naringenin, Chlorogenic acid, Ferulic acid, Ellagic acid, Gallic acid and coffeic acid followed by taxifolin, catechin, syringic acid, methyl gallate, vanillin, kaempferol, cinnamic acid and rutin. GC-MS results showed 14 compounds in S. costus extract. The antibacterial activity of S. costus ethanol extract increased by increasing the concentration of extract from 10 µl to 50 µl for each wells .The inhibition zones were 13 mm and 23mm for S. typhi and Staphylococccus aureus, respectively. Gram (+ve) bacteria found to be more sensitive to SCE than Gram (-ve) bacteria. Similarly; the antifungal activity was increased by increasing the concentration of SCE the inhibition zones were 15.5 mm and 22.5 mm for P. verecossum and A. ochraceous, respectively. A. ochraceous appeared to be more sensitive towards all concentration of the extract. The minimum inhibitory concentration (MIC) of SCE for both bacteria and fungi strains ranged from 0.08 -0.3 mg/ml and 0.25 -1.17 mg/ml, respectively. The results revealed that the SCE can play an important role against the human multi-drug resistant pathogens and can alternate the antibiotics as well as chemical preservatives to control infection and food spoilage contaminants.

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“…Mostly the essential root oil and root powder were used for the medicinal purposes (Nikhat and Fazil 2020 ). Saussurea lappa (SL) has anti-inflammatory activity as documented by reduction of RNA expression of inflammatory cytokines: TNF-α, GM-CSF and IL1β and metalloprotease-9 activity (Lammari et al 2021 ). It inhibits protein and mRNA expression of interleukin-1b (IL-1b) as well as inhibition of phosphorylation of mitogen activated protein kinases (MAPK) (Kang et al 2004 ).…”

Section: Saussurea Lappa (Costus); Phytotherapeutic Agentmentioning

confidence: 99%

Protective and therapeutic potentials of HDL and ApoA1 in COVID-19 elderly and chronic illness patients

Abdel-Hafez

2022

Bull Natl Res Cent

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Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease-2019 (COVID-19). Elderly subjects, obese, and patients with chronic illnesses, are the most affected group. HDL has pleiotropic physiological functions that are affected with alteration(s) in its structure. Main text Inflammation whether septic, immune, or other affects HDL structure and function. COVID-19 is associated with systemic immune-inflammation due to cytokine surge. Viral interaction with erythrocytes and hemoglobin-related compounds (may cause anemia and hypoxia) and other factors may affect HDL function. Trials have been conducted to resume HDL functions using peptide preparation, nutritional, and herbal elements. Conclusions In this review article, I’ll discuss the use of reconstituted HDL (rHDL), Apo-A1 mimetic peptide D-4F, ω-3 polyunsaturated fatty acids, and the powdered roots and/or extract of Saussurea lappa (costus) to avoid comorbidity and mortality of COVID-19 in patients with chronic illness or elderly-age mortality.

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Nanocapsules containing Saussurea lappa essential oil: Formulation, characterization, antidiabetic, anti-cholinesterase and anti-inflammatory potentials

Cited by 40 publications

References 109 publications

Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Antimicrobial activity of bioactive compounds extract from Saussurea costus against food spoilage microorganisms

Protective and therapeutic potentials of HDL and ApoA1 in COVID-19 elderly and chronic illness patients

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