Cytokines in Preterm Delivery

Arababadi, Mohammad Kazemi; Aminzadeh, Fariba; Hassanshahi, Gholamhossein; Khorramdelazad, Hossein; Norouzi, Mojgan; Zarandi, Ebrahim Rezazadeh; Rezayati, Mohammad Taghi; Kennedy, Derek

doi:10.1309/lmy9ilpgsetu2co0

Cited by 17 publications

(9 citation statements)

References 36 publications

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“…GDM is also identified as a pre-diabetic clinical condition offering a unique opportunity to study abnormalities that may occur during initial stages of the fetal development [36,37]. Four main subfamilies of chemokines nominated as CC, CXC, CX3C and C are identified, to date [38][39][40]. It is now well evidenced that members of cytokine/chemokine network are critically involved in patho-physiology of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Serum concentration of angiogenic (CXCL1, CXCL12) and angiostasis (CXCL9, CXCL10) CXC chemokines are differentially altered in normal and gestational diabetes mellitus associated pregnancies

Darakhshan

Fatehi

Hassanshahi

et al. 2019

J Diabetes Metab Disord

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Background The present study was aimed and designed to determine the serum levels of CXCL1 and CXCL12 as angiogenesis along with CXCL9 and CXCL10 as angiostasis, chemokines in, Gestational diabetes mellitus mothers (GDMM) and normal pregnancy mothers (NPM) and neonates who delivered by them. Methods We have recruited 63 pregnant GDMM and 63 normal pregnant mothers at the third trimester of pregnancy to this cross-sectional study. Cord blood specimens were obtained from neonates who were delivered from GDMM and NPM. The serum and cord blood levels of chemokines were measured by ELISA in studied groups. Data were analyzed by chi-square and student's t test between two groups. The P-values less than 0.05 were considered significant. Results Our results revealed that the serum levels of CXCL1, CXCL9 and CXCL12 were increased in GDMM, while no alteration was found in the serum levels of CXCL10 when compared to NPM. We have observed that in neonates the serum levels of angiogeneic chemokines followed an inverse fashion when compared to angiostasis chemokines. Interestingly, CXCL1 and CXCL12 were both increased in neonates who were delivered by GDMM, while, CXCL9 and CXCL10 were decreased in neonates delivered by GDMM. Keywords CXCL1. CXCL9. CXCL10. CXCL12. Chemokine. Gestational diabetes mellitus Abbreviations APGAR is a quick test performed on delivered infants at 1 and 5 min after birth BMI Body mass index FBS Fasting blood sugar GCT Glucose challenge test GDM Gestational diabetes mellitus INF Interferon PAI-1, Plasminogen activator inhibitor-1 TNF-α Tumor necrosis factor-α T2DM Type 2 diabetes mellitus MetS Metabolic syndrome HbA1C The hemoglobin A1C ELISA Enzyme linked immunosorbent assay SPSS Statistical package for the Social sciences GDMM Gestational diabetes mellitus mothers NPM Normal pregnancy mothers * Mojgan Noroozi Karimabad

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Section: Discussionmentioning

confidence: 99%

Serum concentration of angiogenic (CXCL1, CXCL12) and angiostasis (CXCL9, CXCL10) CXC chemokines are differentially altered in normal and gestational diabetes mellitus associated pregnancies

Darakhshan

Fatehi

Hassanshahi

et al. 2019

J Diabetes Metab Disord

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“…In addition to being classified as Th1 and Th2 cytokines, cytokines can also be classified as pro- and anti-inflammatory. Cytokines such as IL-1, IL-2, IL-8, TNF-α, and IFN-γ are proinflammatory, and increased levels of such proinflammatory cytokines are associated with pregnancy complications such as preterm delivery [ 63 ] and intrauterine growth retardation [ 64 ].…”

Section: Cytokines and Pementioning

confidence: 99%

Cytokines as Key Players in the Pathophysiology of Preeclampsia

Raghupathy¹

2013

Med Princ Pract

180

139

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Preeclampsia (PE) is an important, common, and dangerous complication of pregnancy; it causes maternal and perinatal illness and is responsible for a high proportion of maternal and infant deaths. PE is associated with increased blood pressure and proteinuria, with a whole host of other potentially serious complications in the mother and fetus. The maternal syndrome in PE is primarily that of generalized dysfunction of the maternal endothelium, and this generalized endothelial dysfunction appears to be part of an exaggerated systemic inflammatory response that involves maternal leukocytes and proinflammatory cytokines. This review examines evidence that points to a significant role for the maternal immune system; inadequate trophoblast invasion of spiral arteries initiates ischemia and hypoxia in the placenta, resulting in an increased release of proinflammatory cytokines in the placenta. Placental ischemia and hypoxia also cause the enhanced release of trophoblast microparticles into the maternal circulation which stimulates increased induction of proinflammatory cytokines and the activation of maternal endothelial cells. This activation results in a systemic, diffuse endothelial cell dysfunction which is the fundamental pathophysiological feature of this syndrome. Recent evidence also supports important roles for proinflammatory cytokines in hypertension, proteinuria, and edema which are characteristic features of PE.

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“…Several studies have correspondingly demonstrated a significant increase in IL-6 serum levels in patients suffering from COVID-19 [15][16][17]. This cytokine as an inflammatory mediator also plays an essential role in innate and adaptive immune responses; though, it can also have protective and anti-inflammatory properties in some pathologic states [18][19][20]. Furthermore, regarding the findings of recent studies, IL-6 and its receptors could be high potential diagnostic and therapeutic targets in COVID-19 patients [21].…”

Section: Introductionmentioning

confidence: 99%

The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

Abbasifard

Khorramdelazad

2020

Life Sciences

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Interleukin-6 (IL-6), known as an inflammatory cytokine, can be involved in many innate and adaptive immune responses. The role of IL-6 in the pathogenesis of the novel coronavirus disease 2019 (COVID-19) has recently received much more attention due to the spread of the virus and its pandemic potential. Cytokine storm is among the most critical pathological events in patients affected with coronaviruses (CoVs), i.e., severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and COVID-19, causing inflammation-induced lung injury and also occurring as a result of dysregulation of immune responses to the mentioned viruses. IL-6, along with some other inflammatory cytokines, including IL-1 beta (β), IL-8, and tumor necrosis factor-alpha (TNF-α), as well as inflammatory chemokines, can significantly contribute to, fever, lymphopenia, coagulation, lung injury, and multi-organ failure (MOF). Therefore, researchers are to explore novel approaches to treat the disease through targeting of IL-6 and its receptors based on prior experience of other disorders. In this review article, the latest findings on the role of IL-6 in the pathogenesis of COVID-19, as well as therapeutic perspectives, were summarized and discussed.

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Cytokines in Preterm Delivery

Cited by 17 publications

References 36 publications

Serum concentration of angiogenic (CXCL1, CXCL12) and angiostasis (CXCL9, CXCL10) CXC chemokines are differentially altered in normal and gestational diabetes mellitus associated pregnancies

Serum concentration of angiogenic (CXCL1, CXCL12) and angiostasis (CXCL9, CXCL10) CXC chemokines are differentially altered in normal and gestational diabetes mellitus associated pregnancies

Cytokines as Key Players in the Pathophysiology of Preeclampsia

The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

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