The results suggested that the pathophysiological status of both mother and infant are involved in prematurity. Moreover, these findings suggest an inflammatory response in pre-term labor, which probably is controlled by inducible chemokines such as CXCL10.
Background and Objectives: Neonatal hyperbilirubinemia, a high-incidence disease, arises from an imbalance of bilirubin production and elimination. Neonatal jaundice requires medical attention in the clinic. Finding new therapeutic approaches, besides available strategies such as phototherapy, seems necessary. In traditional beliefs Cichorium intybus could exert hepatoprotective effects. In this study we evaluated the effect of administration of hydroalcoholic Cichorium intybus extract to the lactating rats in
ObjectiveApproximately 10% of pregnant women suffer from pregnancy-associated depression. Fluoxetine, as a selective serotonin reuptake inhibitor, is being employed as a therapy for depressive disorders. The present study aimed to determine the effects of fluoxetine on neonatal lung development.MethodsThirty pregnant Wistar rats (weighing 200–250 g) were treated daily with 7 mg/kg fluoxetine from gestation day 0 to gestation day 21, via gavage. The control group received a similar volume of distilled water only. Following delivery, the newborns and their lungs were immediately weighed in both of the groups. The right lung was fixed for histological assessments while the left lung was used for evaluation of the expression of SPC and HoxB5 by the real-time polymerase chain reaction method.ResultsResults have indicated that even though the body weight and the number of neonatal rats in both groups were the same, the lung weight of neonates exposed to fluoxetine was significantly different compared to the control group (P<0.05). Expression of both genes was increased, nonetheless, only elevation of HoxB5 was significant (P<0.05). Histological studies demonstrated that lung tissue in the fluoxetine treatment group morphologically appears to be similar to the pseudoglandular phase, whereas the control group lungs experienced more development.ConclusionAccording to the upregulated expression of HoxB5 concerning histological findings, results of the present study showed that fluoxetine can influence lung growth and may in turn lead to delay in lung development. So establishment of studies to identify the effects of antidepressant drugs during pregnancy is deserved.
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