Cytodiagnosis of chondromyxoid fibroma

Abstract

Chondromyxoid fibroma (CMF) is an unusual tumor that predominantly affects long bones of young adults. We present two cases of CMF that were diagnosed on cytology. The specific cytological features included varying combinations of chondroid, myxoid and fibroid elements. These features when correlated with clinico-radiological findings helped to arrive at a correct diagnosis. Thus a definitive diagnosis of CMF can be made on cytology based on which further line of treatment can be planned.

Cytological diagnosis of chondromyxoid fibroma

“…Walke et al . [ 3 ] reported two cases of CMF of lower end of femur and upper end of tibia, and Siddiqui et al [ 4 ] reported a similar case in fourth metatarsal head of an 18-year-old boy. Both studies revealed background showing chondroid and myxoid elements.…”

Chondromyxoid fibroma of the mandible: Case report and review of the literature

“…However, it is unclear whether malignant CMF actually exists or whether it represents another type of sarcoma that has been misdiagnosed. [ 9 ]…”

Chondromyxoid fibroma of the metatarsal bone: A diagnosis using fine needle aspiration biopsy

“…[ 3 ] The diagnosis becomes difficult if it occurs at unusual sites such as small bones of foot. [ 4 ]…”

“…[ 2 ] Symptomatic patients present with pain, swelling or tenderness, restrictions of movement, and rarely with pathological fracture. [ 2 4 5 ]…”

“…[ 3 ] The individual cells in chondrosarcoma can be uninucleate or binucleate and show nuclear pleomorphism and frequent mitosis. [ 4 ] Immunomarkers are not useful in distinguishing CMF from these entities. [ 3 ]…”