Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433

Khan, Imran; Peng, Jing; Fang, Zhuangjie; Liu, Wei; Zhang, Wenjun; Zhang, Qingbo; Ma, Liang; Zhang, Guangtao; Zhang, Haibo

doi:10.3390/molecules26041080

Cited by 6 publications

(2 citation statements)

References 44 publications

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“…The (−)-4-hydroxysattabacin metabolite from its crude extract had an anti-melanogenic effect in a human epidermal model and they identified it as a new natural melanin reducing agent ( Kim et al, 2017 ). Khan et al (2021) found that cydromicin (1), a secondary metabolite produced by the Tolypocladium sp. (Fungi) strain SCSIO 40433 isolated from arctic glacial sediments, also showed tyrosinase inhibitor activity.…”

Section: Whitening Effectmentioning

confidence: 99%

Application of Marine Microbial Natural Products in Cosmetics

Ding

Chen

2022

Front. Microbiol.

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As the market size of the cosmetics industry increases, the safety and effectiveness of new products face higher requirements. The marine environment selects for species of micro-organisms with metabolic pathways and adaptation mechanisms different from those of terrestrial organisms, resulting in their natural products exhibiting unique structures, high diversity, and significant biological activities. Natural products are usually safe and non-polluting. Therefore, considerable effort has been devoted to searching for cosmetic ingredients that are effective, safe, and natural for marine micro-organisms. However, marine micro-organisms can be difficult, or impossible, to culture because of their special environmental requirements. Metagenomics technology can help to solve this problem. Moreover, using marine species to produce more green and environmentally friendly products through biotransformation has become a new choice for cosmetic manufacturers. In this study, the natural products of marine micro-organisms are reviewed and evaluated with respect to various cosmetic applications.

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Section: Whitening Effectmentioning

confidence: 99%

Application of Marine Microbial Natural Products in Cosmetics

Ding

Chen

2022

Front. Microbiol.

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“…Tolypin is also a peptide mixture [27]. Like kojic acid, cylindromicin is a significant bioactive inhibitor of tyrosinase [28]. Tolyprolinol, a dipeptide produced by Tolypocladium sp.…”

Section: Of 21mentioning

confidence: 99%

Phylogeny and Systematics of the Genus Tolypocladium (Ophiocordycipitaceae, Hypocreales)

Dong

Wang

et al. 2022

JoF

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The taxonomy and phylogeny of the genus Tolypocladium are herein revised based on the most comprehensive dataset to date. Two species-level phylogenies of Tolypocladium were constructed: a single-gene phylogeny (ITS) of 35 accepted species and a multigene phylogeny (nrSSU, nrLSU, tef-1α, rpb1, and rpb2) of 27 accepted species. Three new species, Tolypocladium pseudoalbum sp. nov., Tolypocladium subparadoxum sp. nov., and Tolypocladium yunnanense sp. nov., are described in the present study. The genetic divergences of four markers (ITS, tef-1α, rpb1 and rpb2) among Tolypocladium species are also reported. The results indicated that species of Tolypocladium were best delimited by rpb1 sequence data, followed by the sequence data for the rpb2, tef-1α, and ITS provided regions. Finally, a key to the 48 accepted species of Tolypocladium worldwide is provided.

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