Cyanine conjugates in cancer theranostics

Yang, Li; Zhou, Yiming; Yue, Xiuli; Dai, Zhifei

doi:10.1016/j.bioactmat.2020.09.009

Cited by 55 publications

(45 citation statements)

References 96 publications

(112 reference statements)

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“…Cyanine core is among the most investigated fluorophores due to its favorable optical properties such as high molar absorptivity, narrow absorption/emission bands, reasonable fluorescence quantum yield, and most importantly, tunable fluorescence profile from the UV–vis to NIR range ( Delaey et al, 2000 ; Mishra et al, 2000 ; Kulbacka et al, 2011 ; Bhattarai and Dai, 2017 ; Li Y. et al, 2020 ; Li et al, 2021 ). Additionally, the excellent biocompatibility and low toxicity make them a great candidate for biological studies spanning from imaging to therapy.…”

Section: Cyanine Dyes In Phototherapiesmentioning

confidence: 99%

“…Cyanine fluorophores, especially those excited with a light in the NIR, are studied for both fluorescence imaging and phototherapeutic effect, which renders them as phototheranostic agents ( Jung et al, 2018 ; Chen et al, 2019 ; Li et al, 2021 ). However, the phototherapeutic efficacy of conventional cyanine dyes is not adequate due to low photoconversion efficiency, poor photostability, and undesired aggregation in aqueous solution.…”

Section: Cyanine Dyes In Phototherapiesmentioning

confidence: 99%

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Recent Advances in Cyanine-Based Phototherapy Agents

et al. 2021

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Phototherapies, in the form of photodynamic therapy (PDT) and photothermal therapy (PTT), are very promising treatment modalities for cancer since they provide locality and turn-on mechanism for toxicity, both of which are critical in reducing off-site toxicity. Irradiation of photosensitive agents demonstrated successful therapeutic outcomes; however, each approach has its limitations and needs to be improved for clinical success. The combination of PTT and PDT may work in a synergistic way to overcome the limitations of each method and indeed improve the treatment efficacy. The development of single photosensitive agents capable of inducing both PDT and PTT is, therefore, extremely advantageous and highly desired. Cyanine dyes are shown to have such potential, hence have been very popular in the recent years. Luminescence of cyanine dyes renders them as phototheranostic molecules, reporting the localization of the photosensitive agent prior to irradiation to induce phototoxicity, hence allowing image-guided phototherapy. In this review, we mainly focus on the cyanine dye–based phototherapy of different cancer cells, concentrating on the advancements achieved in the last ten years.

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Section: Cyanine Dyes In Phototherapiesmentioning

confidence: 99%

Section: Cyanine Dyes In Phototherapiesmentioning

confidence: 99%

Recent Advances in Cyanine-Based Phototherapy Agents

et al. 2021

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“…The organic PSs harbor the special merits of good biocompatibility and biodegradability. Various organic nanomaterial-based PSs, such as porphyrin [ [71] , [72] , [73] , [74] , [75] ], boron dipyrromethene (BODIPY) [ [76] , [77] , [78] ], cyanine dyes [ [79] , [80] , [81] , [82] ], aggregation-induced emission (AIE) molecules [ [83] , [84] , [85] , [86] , [87] , [88] , [89] , [90] ], have attracted considerable attention.…”

Section: Reactive Oxygen Species-based Antitumor Therapymentioning

confidence: 99%

Photoactivatable nanogenerators of reactive species for cancer therapy

Zheng

Jin

Liu

et al. 2021

Bioactive Materials

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In recent years, reactive species-based cancer therapies have attracted tremendous attention due to their simplicity, controllability, and effectiveness. Herein, we overviewed the state-of-art advance for photo-controlled generation of highly reactive radical species with nanomaterials for cancer therapy. First, we summarized the most widely explored reactive species, such as singlet oxygen, superoxide radical anion (O 2 ●- ), nitric oxide ( ● NO), carbon monoxide, alkyl radicals, and their corresponding secondary reactive species generated by interaction with other biological molecules. Then, we discussed the generating mechanisms of these highly reactive species stimulated by light irradiation, followed by their anticancer effect, and the synergetic principles with other therapeutic modalities. This review might unveil the advantages of reactive species-based therapeutic methodology and encourage the pre-clinical exploration of reactive species-mediated cancer treatments.

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“…As an FDA-approved photosensitizer, indocyanine green (ICG) has attracted wide interest due to its photothermal and photodynamic therapeutic characteristics [ 20 ], because it can efficiently convert the absorbed NIR laser energy into heat [ 21 ] and produce ROS as well [ 22 ]. Duan et al employed monolayered-double-hydroxide (MLDH) to load ICG and DOX, and demonstrated their excellent tri-modal synergetic anticancer activity [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Polydopamine-Coated Laponite Nanoplatforms for Photoacoustic Imaging-Guided Chemo-Phototherapy of Breast Cancer

Liu

Wang

et al. 2021

Nanomaterials

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Theranostic nanoplatforms combining photosensitizers and anticancer drugs have aroused wide interest due to the real-time photoacoustic (PA) imaging capability and improved therapeutic efficacy by the synergistic effect of chemotherapy and phototherapy. In this study, polydopamine (PDA) coated laponite (LAP) nanoplatforms were synthesized to efficiently load indocyanine green (ICG) and doxorubicin (DOX), and modified with polyethylene glycol-arginine-glycine-aspartic acid (PEG-RGD) for PA imaging-guided chemo-phototherapy of cancer cells overexpressing αvβ3 integrin. The formed ICG/LAP-PDA-PEG-RGD/DOX nanoplatforms showed significantly higher photothermal conversion efficiency than ICG solution and excellent PA imaging capability, and could release DOX in a pH-sensitive and NIR laser-triggered way, which is highly desirable feature in precision chemotherapy. In addition, the ICG/LAP-PDA-PEG-RGD/DOX nanoplatforms could be uptake by cancer cells overexpressing αvβ3 integrin with high specificity, and thus serve as a targeted contrast agent for in vivo PA imaging of cancer. In vivo experiments with 4T1 tumor-bearing mouse model demonstrated that ICG/LAP-PDA-PEG-RGD/DOX nanoplatforms exhibited much stronger therapeutic effect and higher survival rate than monotherapy due to the synergetic chemo-phototherapy under NIR laser irradiation. Therefore, the reported ICG/LAP-PDA-PEG-RGD/DOX represents a promising theranostic nanoplatform for high effectiveness PA imaging-guided chemo-phototherapy of cancer cells overexpressing αvβ3 integrin.

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Cyanine conjugates in cancer theranostics

Cited by 55 publications

References 96 publications

Recent Advances in Cyanine-Based Phototherapy Agents

Recent Advances in Cyanine-Based Phototherapy Agents

Photoactivatable nanogenerators of reactive species for cancer therapy

Polydopamine-Coated Laponite Nanoplatforms for Photoacoustic Imaging-Guided Chemo-Phototherapy of Breast Cancer

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