Cutaneous reactions to substance P and histamine in atopic dermatitis

Coulson, I.H.; Holden, C.A.

doi:10.1111/j.1365-2133.1990.tb08282.x

Cited by 42 publications

(22 citation statements)

References 17 publications

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“…A downregulation of histamine receptors in the dermal blood vessels in psoriasis skin may explain the smaller wheal response. However, we could not find any difference in flare area induced by the injected substances, which is similar in result to the studies done on atopic dermatitis patients [8,16] .…”

Section: Discussionsupporting

confidence: 78%

“…Our result contrasts with the findings reported in previous studies done on atopic dermatitis [8,16] and experimentally induced irritant contact dermatitis [17] . A downregulation of histamine receptors in the dermal blood vessels in psoriasis skin may explain the smaller wheal response.…”

Section: Discussioncontrasting

confidence: 57%

“…Cutaneous reactions to intradermally injected substance P have been studied in atopic dermatitis [8,16] . However, no study has been done to investigate the response of intradermally injected substance P on psoriatic skin until now.…”

Section: Discussionmentioning

confidence: 99%

“…The responses are inhibited by oral pretreatment with an antihistaminic drug, or local treatment with compound 48/80, indicating that the responses induced by substance P are mainly mediated by histamine released from the dermal mast cells. Intradermally injected substance P and histamine have been studied in atopic dermatitis in regard to itch, flare and wheal [8,9] .…”

Section: Introductionmentioning

confidence: 99%

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Responses to Intradermal Injections of Substance P in Psoriasis Patients with Pruritus

Amatya

Nordlind²,

Wahlgren³

2009

Skin Pharmacol Physiol

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Background: Various mediators have been suggested for the pathogenesis of pruritus in psoriasis. Methods: To investigate cutaneous responses of substance P in pruritic lesional and nonlesional areas of psoriasis patients and in healthy controls, substance P, saline and histamine were injected intradermally. After each injection, pruritus, flare and wheal were recorded. Results: There was no statistical difference in the latency period, duration, area under the curve and maximum intensity of pruritus evoked by substance P (10^–5 and 10^–6 mol/l) between psoriasis and healthy control skin. Substance P (10^–5 mol/l) induced a tendency to a greater intensity of pruritus in lesional compared to nonlesional psoriatic skin (p = 0.08). Histamine produced a shorter itch latency period (p < 0.05) and a lower maximum intensity of pruritus (p = 0.05) in lesional psoriasis skin than in healthy control skin. No significant difference in flare area was observed between the psoriasis patients and healthy controls. The histamine-induced wheal was smaller in psoriasis patients than in healthy individuals (p < 0.05). Conclusion: Intradermally injected substance P induced pruritus, flare and wheal in psoriasis patients. However, these responses did not differ significantly from those of the healthy controls.

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Section: Discussionsupporting

confidence: 78%

Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Responses to Intradermal Injections of Substance P in Psoriasis Patients with Pruritus

Amatya

Nordlind²,

Wahlgren³

2009

Skin Pharmacol Physiol

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“…capsaicin, a neurotoxin which depletes sensory neurons of their NP content, has been shown to abolish urticarial reactions [37] and to clear psoriatic lesions [38], w'hilc it is able to enhance delayed-type hypersensi tivity reactions [39,40]. Moreover, altered reactions to the intradermal injection of several NP have been observed in the skin of patients suffering from inflammatory dermato ses, such as atopic eczema, as compared with normal sub jects [41,42]. Alterations of distribution and expression of SP have been observed by immunohistochemistry in atopic dermatitis [43] and psoriasis [44].…”

Section: Np and Skin Diseasesmentioning

confidence: 99%

Neuropeptides and Skin Inflammation

Pincelli

Fantini

Giannetti³

1993

Dermatology

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Neuropeptides (NP) are protein compounds contained both in the central and peripheral nervous system. They can be antidromically released from sensory nerves and are implicated in the so-called neurogenic inflammation. They also exert a number of functions within the immune system and are thought to act as trophic as well as mitogenic substances. Several NP have been detected in human skin by immunohistochemical and radioimmunological techniques, and recent reports have demonstrated that NP could be involved in the mechanisms of certain dermatoses. The involvement of NP in either physiological or patho-physiological skin conditions is discussed. Moreover, a few questions, which still need to be addressed, are raised, and future directions this field of research should take are outlined.

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