Natural History of Sensitizations in Atopic Dermatitis

Guillet, G.

doi:10.1001/archderm.1992.01680120059004

Cited by 163 publications

(38 citation statements)

References 36 publications

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“…Atopy prevalences ranged from 47% to 75% (Table II). [10][11][12][13][14][15][16][17][18][19][20][21] Lower levels of atopy-AD association were seen in cross-sectional population-based studies. Thirteen of 65 surveys were identified, and atopy prevalences ranged from 7% to 78% (Table III).…”

Section: How Atopic Is Ad At the Population Level?mentioning

confidence: 99%

“…Of these, 7 studies concluded that the number of SPTs, IgE-antibody specificities, and/or IgE levels were significantly associated with AD severity (Table IV). [12][13][14]16,22,[32][33][34] How useful is the knowledge of IgE sensitization in discriminating between the phenotype of AD and other skin diseases or persons without skin disease?…”

Section: Is Ige Sensitization a Marker Of Severity In Ad?mentioning

confidence: 99%

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How atopic is atopic dermatitis?

Flohr

Johansson²,

Wahlgren³

et al. 2004

Journal of Allergy and Clinical Immunology

274

206

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Section: How Atopic Is Ad At the Population Level?mentioning

confidence: 99%

Section: Is Ige Sensitization a Marker Of Severity In Ad?mentioning

confidence: 99%

How atopic is atopic dermatitis?

Flohr

Johansson²,

Wahlgren³

et al. 2004

Journal of Allergy and Clinical Immunology

274

206

View full text Add to dashboard Cite

“…The overall prevalence of food allergy in infants with AD ranged from 20 to 80% in various studies, and may be estimated at 30%. Guillet found that severe AD and younger age are risk factors for food allergy [12]. Clinical symptoms of patients with food-sensitive AD often improve with an increase in age [13].…”

Section: Prevalence Of Food Allergy In Admentioning

confidence: 99%

Allergens in Atopic Dermatitis

Dai

2007

Clinic Rev Allerg Immunol

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Allergens play an essential role in atopic dermatitis, either intrinsic or extrinsic. They provoke cutaneous inflammation via IgE-dependent and cell-mediated immune reactions. Food allergens have a well-known contribution to disease activity of atopic dermatitis, especially in infants and young children. However, the importance of inhaled allergens is still under investigation. For clinical implication, identification of individualized allergens is an ideal strategy for better control of atopic dermatitis and avoidance of atopic march. The aim of this article is to discuss the common allergens in atopic dermatitis (AD), the specificity and sensitivity of laboratory tests for allergens, and the clinical effect of various preventions.

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“…When it is well known that atopic dermatitis [37][38][39][40][41][42] and food allergy [43][44][45][46][47][48][49] have their onset within the first year of life in 70-100% of infants [37][38][39][40][41][42], and in the second in 69-96% of cases [43,44], it may not be clear that allergy to a panel of foods be gins before the first year of age in a wide proportion of ba bies [45][46][47][48][49]. For example allergy to cow milk evidently begins in at least 72%, and to egg in 71% of infants [45][46][47].…”

Section: Introductionmentioning

confidence: 99%

A Great Discovery Allergy and Asthma are fully Genetic in Children

Cantani¹

2015

Scientific J Genet Gene Ther

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Background: Allergic asthma and rhinitis, atopic dermatitis, urticaria and food allergy are genetic diseases of infants and children. Several investigators have provided evidence for a genetic localization for atopy. Babies of atopic parents are at high risk of developing atopic diseases, however the phenotypic expression of such diseases varies widely, being very mild in some infants and children, severe and frustrating in many, even life-threatening in others, being also common, disabilitating, and chronic.Methods: A meta-analysis was done of all available studies on the age of onset of the atopic march, without attempting at being comprehensive in this meta-analysis, but instead selecting what appeared the most relevant articles in the literature. Results:In the first year of life, there is the onset of atopic dermatitis in 79,8% [ 60,2% to 100%], of cow's milk allergy in 72,7%, egg allergy in 71%, and fish allergy in 51,3% of babies. Asthma starts in the first year of life in 41,8%, in the 2nd in 49,3%, and within the 8th year in 92,5% of children. Allergic rhinitis begins in 35% of babies in the 1st year of life, and in 59% or 13-19% in those aged 2-5 years. It seems therefore that the role of pediatric allergy and immunology has been hitherto somewhat obscured, as shown by the atopic march. Conclusion:It follows that this role is instead substantial, unmatched, focusing on the early and often very early onset of the atopic march, which needs strategic interventions in the very first months of life or even before birth. As the main goal of modern medicine is prevention of chronic and severe diseases, the possibility of preventing such disorders in predisposed children has stimulated the investigators' imagination since the beginning of the century, when atopic diseases were not as common as now.[11]. There is a significant linkage between total IgE levels and several of these markers, particularly IL-4R [12] and . A linkage of chromosome markers with bronchial hyperreactivity (BHR) and total IgE con centrations has been reported [14]. Two genes account for 78% of the genetic predisposition to high IgE levels [15]. However this linkage has not been confirmed by others, either for total serum IgE or for BHR [16,17] The genes for the ß subunit of the high affinity immunoglobulin E receptor (FceRI-ß) are located on 11q13 [18], and are associated, but without a complete unanimity of researchers, with one or more genes coding for atopy [11]. The initial study showing a dominant gene on this chromosome [19] has been confirmed [20][21][22][23][24] or not [25][26][27][28][29][30], while an association between high serum IgE levels and D11S97 on chromo some 11q has been found in Japanese sub jects [31]. There is no association of atopic dermatitis with chromosome 11q [32], but with the FceRI-ß [33]. Other genes located on 14q23, 14q32, and 14q11.2 may contain loci predisposing to high IgE levels, while those on 12q15 and 12q24 are associated with IFN-g concentrations [11] and show linkage with asthma and tota...

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Natural History of Sensitizations in Atopic Dermatitis

Abstract: The detection of food allergy in a child presenting with AD is likely to indicate a prognosis of severe AD and should be considered by dermatologists as a potentially important predictor of further respiratory symptoms.

Cited by 163 publications

References 36 publications

How atopic is atopic dermatitis?

How atopic is atopic dermatitis?

Allergens in Atopic Dermatitis

A Great Discovery Allergy and Asthma are fully Genetic in Children

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