Cutaneous adverse events following 771 doses of the inactivated and mRNA COVID‐19 vaccines: A survey study among health care providers

Abstract

Introduction As Coronavirus disease 19 (COVID‐19) still continues to affect humanity worldwide, different types of COVID‐19 vaccines are being administered to maintain immunization against COVID‐19. As both the inactivated and mRNA vaccines are now being applied prevalently, systemic adverse events along with cutaneous side effects are frequently being reported in the literature. Aim In our study, we aimed to determine the cutaneous adverse effects of the inactivated (Sinovac‐CoronaVac) and mRNA (Pfizer‐BioNTech) vaccines in healthcare providers in a tertiary referral hospital. Methods A web‐based survey consisting of 26 questions related to the systemic and cutaneous side effects of the inactivated and mRNA COVID‐19 vaccines, was formed. The online questionnaire was spread among the healthcare professionals working in a tertiary referral hospital via common instant messaging groups and e‐mail. Findings A total number of 234 participants were included in the study. One hundred fifty‐seven were female whereas 77 were male. The mean age was 31.51 years. Eighty‐nine respondents reported to have at least one cutaneous side effect after COVID‐19 vaccination. Most commonly observed cutaneous side effects were local injection site reactions. Pfizer‐BioNTech vaccine at the first and second doses, was shown to have statistically significantly higher rates of systemic and cutaneous adverse events compared to the Sinovac‐CoronaVac vaccine. Results Our study shows that both inactivated and mRNA COVID‐19 vaccines are associated with transient local injection site reactions, no severe systemic or cutaneous adverse events were observed in our study population.

Adverse Events Following Immunization of mRNA and Inactivated Vaccines Against COVID-19 at Universitas Indonesia Hospital: A Cross-Sectional Study

“…8 In this study, 130 participants (39.5%) reported discomfort at the injection site, the highest prevalence of AEFI symptoms in the first 15 minutes after immunization. Then, 44 individuals (16.9%) and 70Additionally, soreness at the injection site is the most prevalent adverse event connected to the site of injection, which is similar with previous research by Bostan et al, in which a local injection site response was the most often observed side effect 9. In this study, the perceived severity of AEFI was dominated by mild severity, while moderate, severe, and potentially life-threatening events occurred in a few cases only.…”

Dermatological Complications of COVID 19 Vaccines: An Updated Review

“…26 When compared with the Pfizer vaccine, CoronaVac was associated with a significantly lower incidence of local injection-site reactions. 27,28 There is a lack of knowledge about the cutaneous or systemic adverse effects of CoronaVac since the findings of the phase 3 trials have not been published yet.…”

“…However, some patients received glucocorticoids, pain relievers, or antihistamines. 19,27,35,36,38,39 Moreover, many patients were given unneeded antibiotics due to fears of cellulitis or other infections, which emphasize the importance of improving the awareness of the physicians that there is no need to postpone the second dose of the vaccine due to the benign DLRs. Regarding the AstraZeneca vaccine, there are only very few scattered case reports documenting the presence of DLRs following the vaccine.…”

Cutaneous adverse events following the inactivated and mRNA COVID‐19 vaccines: Correspondence

“…We would like to share ideas on “Cutaneous Adverse Events Following 771 Doses of the Inactivated and mRNA COVID‐19 Vaccines: a Survey Study Among Health Care Providers 1 1 although no serious systemic or cutaneous adverse effects were detected in the study population. Although the COVID‐19 vaccine is good, we are all concerned that it may be detrimental as well.…”