Current status and prospects of metal–organic frameworks for bone therapy and bone repair

Li, Minmin; Yin, Senlin; Lin, Mingzi; Chen, Xuelin; Pan, Ying; Peng, Yanqiong; Sun, Jianbo; Kumar, Abhinav; Liu, Jian Qiang

doi:10.1039/d2tb00742h

Cited by 123 publications

(43 citation statements)

References 157 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antimicrobial agents are inorganic agents compounded with organic substances, porous materials, or polymeric materials through chemical synthesis, physical adsorption, and other methods. 21 Among them are metal–organic frameworks (MOFs) with metal ions as the center, and organic ligands, through chemical coordination, that can build a three-dimensional structure with high porosity and high effective surface area, 22,23 which can be used to carry antimicrobial agents. It is worth mentioning that the metal centers of certain MOFs also show antibacterial properties.…”

Section: Application Of Ti-based Mof In Antibacterial Treatmentsmentioning

confidence: 99%

Recent advances in Ti-based MOFs in biomedical applications

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Application Of Ti-based Mof In Antibacterial Treatmentsmentioning

confidence: 99%

Recent advances in Ti-based MOFs in biomedical applications

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…[215] Since then, CDT has gradually become a new strategy of cancer treatment using transition metal ions as catalysts to produce ROS under TME to induce cancer cell death. [216][217][218][219] However, the CDT performance is greatly restricted by the weak acidity in tumor tissues as well as the low concentration of H 10A). [136] After modifying with BSA, the FeO/ MoS 10B).…”

Section: Ptt-combined Pdtmentioning

confidence: 99%

Molybdenum‐Based Nanomaterials for Photothermal Cancer Therapy

Zhou

et al. 2022

Advanced NanoBiomed Research

View full text Add to dashboard Cite

Figure 2. Preparation of Mo-based NMs via ultrasound-assisted liquid-phase exfoliation strategy. A) Monolayer molybdenum dichalcogenides (MoS 2 andMoSe 2 ) nanosheets possess superior biomedical stability and high photothermal conversion effect. Reproduced with permission. [147] Copyright 2018, American Chemical Society. B) Single layer of MoSe 2 nanosheets as a novel PAI/PTT theranostic nanoagent. Reproduced with permission. [143] Copyright 2018, Royal Society of Chemistry. C) Hydrophobic MoSe 2 nanosheets as a photothermal-chemotherapeutic agent. Reproduced with permission. [149] Copyright 2020, Royal Society of Chemistry. D) Oxygen-deficient α-MoO 3Àx nanoflakes exhibit high biocompatibility and physiological stability. Reproduced with permission. [150] Copyright 2018, Wiley-VCH.

show abstract

“…Since their discovery in 1989, metal organic frameworks (MOFs), built from organic linkers and metal ions, have attracted growing interest for a variety of applications, including catalysis, gas storage, energy, and more recently, biomedicine [ 1 , 2 , 3 , 4 , 5 , 6 ]. Nanoscale MOFs (nanoMOFs) were employed in the drug delivery field for the treatment of cancer, infections, diabetes, wounds, and other severe diseases [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Acetic Acid-Modulated Room Temperature Synthesis of MIL-100 (Fe) Nanoparticles for Drug Delivery Applications

Ding

Qiu

Rouzière

et al. 2023

IJMS

View full text Add to dashboard Cite

Due to their flexible composition, large surface areas, versatile surface properties, and degradability, nanoscale metal organic frameworks (nano MOFs) are drawing significant attention in nanomedicine. In particular, iron trimesate MIL-100 (Fe) is studied extensively in the drug delivery field. Nanosized MIL-100 (Fe) are obtained mostly by microwave-assisted synthesis. Simpler, room-temperature (RT) synthesis methods attract growing interest and have scale-up potential. However, the preparation of RT MIL100 is still very challenging because of the high tendency of the nanoparticles to aggregate during their synthesis, purification and storage. To address this issue, we prepared RT MIL100 using acetic acid as a modulator and used non-toxic cyclodextrin-based coatings to ensure stability upon storage. Hydrodynamic diameters less than 100 nm were obtained after RT synthesis, however, ultrasonication was needed to disaggregate the nanoparticles after their purification by centrifugation. The model drug adenosine monophosphate (AMP) was successfully encapsulated in RT MIL100 obtained using acetic acid as a modulator. The coated RT MIL100 has CD-exhibited degradability, good colloidal stability, low cytotoxicity, as well as high drug payload efficiency. Further studies will focus on applications in the field of cancer therapy.

show abstract

Current status and prospects of metal–organic frameworks for bone therapy and bone repair

Abstract: In the present perspective, the use of MOFs in bone therapy and bone repair has been summarized, and an outlook on the future direction of MOFs in bone therapy and bone repair has been provided.

Cited by 123 publications

References 157 publications

Recent advances in Ti-based MOFs in biomedical applications

Recent advances in Ti-based MOFs in biomedical applications

Molybdenum‐Based Nanomaterials for Photothermal Cancer Therapy

Acetic Acid-Modulated Room Temperature Synthesis of MIL-100 (Fe) Nanoparticles for Drug Delivery Applications

Contact Info

Product

Resources

About