Recent advances in Ti-based MOFs in biomedical applications

Liu, Jianqiang; Chen, Jinyi; Cheng, Fan; Luo, Dongwen; Huang, Jiefeng; Ouyang, Jun; Nezamzadeh‐Ejhieh, Alireza; Peng, Yanqiong; Khan, M. Shahnawaz

doi:10.1039/d2dt02470e

Cited by 75 publications

(39 citation statements)

References 116 publications

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“…11,12 Lately, metalorganic frameworks (MOFs) have emerged as new photosensitizers due to the strong electron energy level transition, good stability, and good biocompatibility. [13][14][15] Among the various MOFs, NH 2 -MIL-53 (Fe) was found to be a novel photosensitizer due to its stronger electronic transition and wider absorption bands caused by the antenna effect. 16 The stimulated electrons could transition along the organic skeleton and be captured by oxygen, and the oxygen was restored to poisonous superoxide anions ( O 2 À ) to cause damage to tumor cells.…”

Section: Introductionmentioning

confidence: 99%

A multiphoton transition activated iron based metal organic framework for synergistic therapy of photodynamic therapy/chemodynamic therapy/chemotherapy for orthotopic gliomas

Cao

Xue

et al. 2023

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

A multiphoton transition activated iron based metal organic framework for synergistic therapy of photodynamic therapy/chemodynamic therapy/chemotherapy for orthotopic gliomas

Cao

Xue

et al. 2023

J. Mater. Chem. B

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“…In general, two different types of MRI contrast agents exist. Positive ones (e.g., based on gadolinium chelates) predominantly shorten the longitudinal relaxation time T 1 , so that the signal intensity in the region of interest is increased (hyperintensity in T 1 -weighted images) [ 21 , 22 ]. Negative contrast agents (e.g., magnetic iron oxides) shorten the transverse relaxation time T 2 , leading to decreased signal intensity (hypointensity in T 2 -weighted images) [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Europium Substitution on the Structural, Magnetic and Relaxivity Properties of Mn-Zn Ferrite Nanoparticles: A Dual-Mode MRI Contrast-Agent Candidate

et al. 2023

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Magnetic nanoparticles (MNPs) have been widely applied as magnetic resonance imaging (MRI) contrast agents. MNPs offer significant contrast improvements in MRI through their tunable relaxivities, but to apply them as clinical contrast agents effectively, they should exhibit a high saturation magnetization, good colloidal stability and sufficient biocompatibility. In this work, we present a detailed description of the synthesis and the characterizations of europium-substituted Mn–Zn ferrite (Mn0.6Zn0.4EuxFe2−xO4, x = 0.00, 0.02, 0.04, 0.06, 0.08, 0.10, and 0.15, herein named MZF for x = 0.00 and EuMZF for others). MNPs were synthesized by the coprecipitation method and subsequent hydrothermal treatment, coated with citric acid (CA) or pluronic F127 (PF-127) and finally characterized by X-Ray Diffraction (XRD), Inductively Coupled Plasma (ICP), Vibrating Sample Magnetometry (VSM), Fourier-Transform Infrared (FTIR), Dynamic Light Scattering (DLS) and MRI Relaxometry at 3T methods. The XRD studies revealed that all main diffraction peaks are matched with the spinel structure very well, so they are nearly single phase. Furthermore, XRD study showed that, although there are no significant changes in lattice constants, crystallite sizes are affected by europium substitution significantly. Room-temperature magnetometry showed that, in addition to coercivity, both saturation and remnant magnetizations decrease with increasing europium substitution and coating with pluronic F127. FTIR study confirmed the presence of citric acid and poloxamer (pluronic F127) coatings on the surface of the nanoparticles. Relaxometry measurements illustrated that, although the europium-free sample is an excellent negative contrast agent with a high r2 relaxivity, it does not show a positive contrast enhancement as the concentration of nanoparticles increases. By increasing the europium to x = 0.15, r1 relaxivity increased significantly. On the contrary, europium substitution decreased r2 relaxivity due to a reduction in saturation magnetization. The ratio of r2/r1 decreased from 152 for the europium-free sample to 11.2 for x = 0.15, which indicates that Mn0.6Zn0.4Eu0.15Fe1.85O4 is a suitable candidate for dual-mode MRI contrast agent potentially. The samples with citric acid coating had higher r1 and lower r2 relaxivities than those of pluronic F127-coated samples.

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“…Recently, metal-organic frameworks (MOFs) have had good designability, well-defined pores, stimulus responsiveness, a large surface area, and a controllable morphology [16][17][18][19]. Various MOFs have been developed and utilized as functional materials in many applications, such as gas sorption [20][21][22][23][24][25], heterogeneous catalysts [26][27][28][29][30][31], luminescent sensors [32][33][34][35][36], electrochemical aptasensors [37][38][39][40][41], and in biomedical applications [42][43][44][45]. By virtue of the advantages of porous MOFs, they provide an available platform for highly efficient drug loading and controlled drug release in specific contexts.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Metal–Organic-Framework-Based Nanocarriers for Controllable Drug Delivery and Release

et al. 2022

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Metal–organic frameworks (MOFs) have a good designability, a well-defined pore, stimulus responsiveness, a high surface area, and a controllable morphology. Up to now, various MOFs have been widely used as nanocarriers and have attracted lots of attention in the field of drug delivery and release because of their good biocompatibility and high-drug-loading capacity. Herein, we provide a comprehensive summary of MOF-based nanocarriers for drug delivery and release over the last five years. Meanwhile, some representative examples are highlighted in detail according to four categories, including the University of Oslo MOFs, Fe-MOFs, cyclodextrin MOFs, and other MOFs. Moreover, the opportunities and challenges of MOF-based smart delivery vehicles are discussed. We hope that this review will be helpful for researchers to understand the recent developments and challenges of MOF-based drug-delivery systems.

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Recent advances in Ti-based MOFs in biomedical applications

Abstract: Heydays Metal-Organic Frameworks (MOFs), basically inorganic-organic hybrid materials, have gained tremendous attention due to their vast applications. MOFs have shown enormous applications in almost every research field. But the area...

Cited by 75 publications

References 116 publications

A multiphoton transition activated iron based metal organic framework for synergistic therapy of photodynamic therapy/chemodynamic therapy/chemotherapy for orthotopic gliomas

A multiphoton transition activated iron based metal organic framework for synergistic therapy of photodynamic therapy/chemodynamic therapy/chemotherapy for orthotopic gliomas

Effect of Europium Substitution on the Structural, Magnetic and Relaxivity Properties of Mn-Zn Ferrite Nanoparticles: A Dual-Mode MRI Contrast-Agent Candidate

Recent Advances in Metal–Organic-Framework-Based Nanocarriers for Controllable Drug Delivery and Release

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