Current Knowledge on Growth Hormone and Insulin-Like Growth Factors and their Role in the Central Nervous System: Growth Hormone in Down Syndrome

Abstract

Down syndrome (DS) is a chromosomal disorder associated with short stature and psychomotor delay. Growth hormone (GH) and insulin-like growth factor I (IGF-I) are of interest in DS as the pronounced growth retardation coincides in time when GH becomes essential for growth. Simultaneously mean intelligence quotient (IQ) decreases markedly.There is no evidence of a general GH deficiency in children with DS, but suboptimal endogenous production of GH and selective deficiency of IGF-I have been demonstrated. GH and IGF-I are important brain growth promoting factors. IGF receptors are present in brain cells from foetuses with DS, but there is no information as to whether disturbances of intracerebral GH binding or IGF-I production may contribute to the brain dysfunction in DS.GH therapy normalized growth velocity and improved fine motor performance in young children with DS, but the limited therapy was followed by a marked "catch-down" growth and lacked effect on final height. In adolescents with DS treatment with GH during early childhood show some positive late effects, where subjects previously treated had greater head circumference and improved performance regarding cognitive function and motor skills.Few studies have addressed the effect of GH in Down syndrome. Nevertheless, GH has been designated beneficial effects on cognition, energy, mood and behaviour through extensive studies in several other conditions and it is not unlikely that GH may have similar effects in DS. It should be emphasised that even small changes in psychomotor attainment may be of substantial importance in a developmentally delayed population.

Kadar Zinc Dan Kadar Igf-1 Serum Pada Anak Sekolah Dasar Di Kecamatan Tuah Negeri Kabupaten Musirawas

“…7,8 Hormon GH dan IGF-1 sering dihubungkan dengan kondisi gangguan pertumbuhan dan perkembangan karena keterlambatan pertumbuhan terjadi pada saat hormon tersebut berperan penting dalam pertumbuhan. 9 Kadar IGF-1 memiliki korelasi positif dengan usia, tinggi badan dan periode pubertas. Kadar IGF-1 serum meningkat selama masa pertumbuhan anak, mencapai puncaknya pada masa pubertas dan menurun sesuai dengan proses penuaan.…”

The Effect of Infant Massage on Nutritional Status and IGf-1 of Malnourished Babies Aged 6-12 Months

“…Growth hormone and IGF-1 are often associated with conditions of impaired growth and development because growth retardation occurs when these hormones play an important role in growth. (Myrelid A, 2012) Based on this background, researchers are interested in scientifically proving the effect of baby massage on improving nutritional status (weight/age) and IGF-1, in malnourished infants aged 6-12 months in Mataram city.…”

Hubungan antara Insulin-like Growth Factor-1 dengan Pertumbuhan dan Perkembangan Anak Sindrom Down

“…11,12 Hormon GH dan IGF-1 sering dihubungkan dengan kondisi gangguan pertumbuhan dan perkembangan karena keterlambatan pertumbuhan terjadi pada saat hormon tersebut berperan penting dalam pertumbuhan. 13 Beberapa penelitian menunjukkan kadar IGF-1 yang rendah pada anak sindrom Down, 14,15 tetapi ada pula yang menyatakan kadar IGF-1 masih dalam batas normal. 16 Penelitian Hestnes dan Ragusa menunjukkan bahwa kadar IGF-1 memiliki korelasi positif dengan usia, periode pubertas, dan tinggi badan, namun tidak berhubungan dengan BMI.…”