Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells

Ma, Jia; Fang, Binbin; Zeng, Fanpeng; Pang, Haijie; Zhang, Jing; Shi, Ying; Wu, Xueping; Cheng, Lan; Ma, Cong; Xia, Jun; Wang, Zhiwei

doi:10.1016/j.toxlet.2014.09.014

Cited by 116 publications

(72 citation statements)

References 51 publications

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“…Zhang et al (2015) suggested that curcumin affects the cell invasion and proliferation of A375 cells by increasing the rate of apoptosis [30]. This effect has also been seen in other cancer cells treated with curcumin, including prostate [26], papillary thyroid [22], pancreatic [29], ovarian [28], and colon cancer cells [23]. Other effects on cancer cells have been observed, such as nuclear shrinkage and chromatin condensation in cutaneous T-cell lymphoma cells [25], and induction of cell cycle arrest in prostate cancer cells [26].…”

Section: Cytotoxicity and Anticancer Propertiesmentioning

confidence: 83%

“…It has been reported to kill tumor cells and inhibit the proliferation of cancer cells, primarily through induction of apoptosis. This activity has been observed against malignant cells including: breast [19,20], thyroid [21,22], colon [23], leukemia [24,25], prostate [26], lung [27], ovarian [28] and pancreatic cancer cells [29], as well as malignant melanoma cells [30]. Curcumin has also been shown to inhibit vital processes of cancerous cells, including adhesion, migration, invasion, and spreading.…”

Section: Introductionmentioning

confidence: 98%

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Characteristics of Curcumin-Loaded Bacterial Cellulose Films and Anticancer Properties against Malignant Melanoma Skin Cancer Cells

et al. 2018

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Curcumin-loaded bacterial cellulose films were developed in this study. Curcumin was absorbed into never-dried bacterial cellulose pellicles by 24-h immersion in solutions of curcumin in the range of 0.2-1.0 mg /mL. The curcumin-loaded bacterial cellulose pellicles were then air-dried and characterized. The mechanical properties of curcumin-loaded bacterial cellulose films, particularly the stretching properties, appeared to be lower than those of bacterial cellulose film. This was especially evident when the loading concentration of curcumin was higher than 0.4 mg/mL. Fourier-transform infrared spectroscopy analysis indicated an interaction between bacterial cellulose microfibrils and curcumin. Controlled release of curcumin was achieved in buffer solutions containing Tween 80 and methanol additives, at pH 5.5 and 7.4. Curcumin-loaded bacterial cellulose films prepared with curcumin solutions at concentrations of 0.5 and 1.0 mg/mL displayed antifungal activities against Aspergillus niger. They also exhibited anticancer activity against A375 malignant melanoma cells. No significant cytotoxic effect was observed against normal dermal cells, specifically, human keratinocytes and human dermal fibroblasts.

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Section: Cytotoxicity and Anticancer Propertiesmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 98%

Characteristics of Curcumin-Loaded Bacterial Cellulose Films and Anticancer Properties against Malignant Melanoma Skin Cancer Cells

et al. 2018

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“…[54][55][56] Moreover, miR-7 is reported to inhibit cell growth and invasion in pancreatic cancer cells, and could sensitize non-small cell lung cancer cells to paclitaxel. 57,58 A study in cervical cancer found that miR-7 inhibited the metastasis and invasion of cervical cancer by targeting focal adhesion kinase (FAK) at the transcriptional and translational levels. 59 Biological functions of circRNAs in cancer by manipulating miR-138…”

Section: Roles Of Circrnas In the Oncogenesis And The Malignant Behavmentioning

confidence: 99%

Circular RNA participates in the carcinogenesis and the malignant behavior of cancer

2016

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Circular RNAs (circRNAs) are long, non-coding RNAs that result from the non-canonical splicing of linear premRNAs. However, the characteristics and the critical role of circRNA in co-/post-transcriptional regulation were not well recognized until the "microRNA sponge" function of circRNA is discovered. Recent studies have mainly been devoted to the function of the circular RNA sponge for miR-7 (ciRS-7) and sex-determining region Y (SRY) by targeting microRNA-7 (miR-7) and microRNA-138 (miR-138), respectively. In this review, we illustrate the specific role of circRNAs in a wide variety of cancers and in regulating the biological behavior of cancers via miR-7 or miR-138 regulation. Furthermore, circRNA, together with its gene silencing ability, also shows its potential in RNA interference (RNAi) therapy by binding to target RNAs, which provides a novel perspective in cancer treatment. Thus, this review concerns the biogenesis, biological function, oncogenesis, progression and possible therapies for cancer involving circRNAs.

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“…Likewise, ectopic expression of cullin 5, a novel target gene of miR-7, inhibits HCC cell proliferation, arrests cell cycle progression, and suppresses colony formation, although the exact pathway remains unclear [23] . Moreover, which miR-7 targeted SET domain containing 8 leading to increased p53 expression and decreased Bcl-2 level, curcumin suppressed cell growth, migration and invasion, and induced apoptosis in PC cells, indicating that targeting miR-7 is a useful therapeutic option for PC [33] . Although knockdown of LIV-1 (a zinc transporter) can upregulate expression of miR-7 in PC cells, the exact role of miR-7 in the maintenance of cancer-stem-cellrelated phenotypes in PC remains unclear [34] .…”

Section: Hccmentioning

confidence: 99%

Role of microRNA-7 in digestive system malignancy

Chen¹

2016

WJGO

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There are several malignancies of the digestive system (including gastric, pancreatic and colorectal cancers, and hepatocellular carcinoma), which are the most common types of cancer and a major cause of death worldwide. MicroRNA (miR)-7 is abundant in the pancreas, playing an important role in pancreatic development and endocrine function. Expression of miR-7 is downregulated in digestive system malignancies compared with normal tissue. Although there are contrasting results for miR-7 expression, almost all research reveals that miR-7 is a tumor suppressor, by targeting various genes in specific pathways. Moreover, miR-7 can target different genes simultaneously in different malignancies of the digestive system. By acting on many cytokines, miR-7 is also involved in many gastrointestinal inflammatory diseases as a significant carcinogenic factor. Consequently, miR-7 might be a biomarker or therapeutic target gene in digestive system malignancies.

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Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells

Cited by 116 publications

References 51 publications

Characteristics of Curcumin-Loaded Bacterial Cellulose Films and Anticancer Properties against Malignant Melanoma Skin Cancer Cells

Characteristics of Curcumin-Loaded Bacterial Cellulose Films and Anticancer Properties against Malignant Melanoma Skin Cancer Cells

Circular RNA participates in the carcinogenesis and the malignant behavior of cancer

Role of microRNA-7 in digestive system malignancy

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