Curcumin, hemostasis, thrombosis, and coagulation

Abstract

Atherothrombotic cardiovascular disease is a major cause of mortality throughout the world. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of cardiovascular disease and can help in modifying its progression, particularly in hemostasis and the coagulation process, as well as altering platelet function tests and some coagulation parameters. Curcumin is a polyphenol derived from the Curcuma longa plant and has been used extensively in complementary and alternative medicine, as it is nontoxic and safe with various therapeutic properties. Modern scientific research has demonstrated its anti-inflammatory, antioxidant, anti-carcinogenic, antithrombotic, and cardiovascular protective effects. The present study reviewed previous studies in the literature, which support the positive activity of curcumin in hemostasis, anticoagulation, and fibrinolysis. We also presented molecular mechanisms associated with the antiplatelet and anticoagulant activities of curcumin and potential implications for the treatment of cardiovascular disease.

Biological properties of metal complexes of curcumin

“…However, approved drugs for the treatment of cancer are usually limited by potential undesirable side effects such as hepatotoxicity, nephrotoxicity, ototoxicity, reduction in platelet counts, and myelosuppression . Curcumin, a natural polyphenolic compound and the principal coloring agent found in the rhizomes of Curcuma longa (Zingiberaceae), has several health benefits, including antioxidant , anti‐inflammatory , immunomodulatory , antiarthritic , antithrombotic , pulmonoprotective , lipid‐modifying , neuroprotective , anticancer , antidiabetic, and hepatoprotective properties. Numerous reports have indicated that curcumin is quite safe and nontoxic to humans up to doses of 12 g/day .…”

The protective role of curcumin in myocardial ischemia–reperfusion injury

“…Curcumin is relatively safe and nontoxic; its therapeutic approach exhibits a diverse range of biological effects, such as anti-inflammatory (Panahi, Hosseini, et al, 2015;Sahebkar, Cicero, Simental-Momtazi et al, 2016), anticoagulant (Keihanian, Saeidinia, Bagheri, Johnston, & Sahebkar, 2018), hepatoprotective (Rahmani et al, 2016), analgesic (Sahebkar & Henrotin, 2016), antidiabetic (Panahi, Khalili, et al, 2018), lipid-lowering (Panahi, Kianpour, et al, 2016), and antidepressant (Panahi, Badeli, Karami, & Sahebkar, 2015).…”

Diarylheptanoids as nutraceutical: A review

“…1, 7-bis (4-hydroxyphenyl)-3-hydroxy-1,3heptadien-5-one isolated from A. blepharocalyx showed antiplatelet activity (Doug et al, 1998). Keihanian et al (2018) reported anti-coagulant activities of curcumin and its role in treatment of cardiovascular diseases.…”