Biological properties of metal complexes of curcumin

Shakeri, Abolfazl; Panahi, Yunes; Johnston, Thomas P.; Sahebkar, Amirhossein

doi:10.1002/biof.1504

Cited by 82 publications

(60 citation statements)

References 145 publications

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“…The indirect mode of action is based on metal chelation, an approach that has demonstrated its effectiveness on reduction of ROS production and on ROS-mediated pathologies. 10,[20][21][22] Among the most studied aforementioned metal-chelating antioxidants, we can mention polyphenols 23 including flavonoids 24,25 (e.g., quercetin, 26 epigallocatechin-3-gallate 20,27 ), resveratrol 28 or curcumin, 29 capsaicin, 30 quinolines (e.g., clioquinol, 21 8-hydroxyquinoline derivatives 20,31 ), and the siderophores deferiprone 32 and deferoxamine (this latter will be further discussed below). While metal-chelating peptides have been widely studied in the last decades for their copper-binding properties, 33,34 Fe(III) has hardly been considered, with only few examples of peptides 35 and peptide derivatives functionalized with well-known iron-chelating chemical moieties (e.g., EDTA, hydroxamate).…”

Section: Resultsmentioning

confidence: 99%

Both metal-chelating and free radical-scavenging synthetic pentapeptides as efficient inhibitors of reactive oxygen species generation

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Both metal-chelating and free radical-scavenging synthetic pentapeptides as efficient inhibitors of reactive oxygen species generation

et al. 2020

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“…Discrepancies in the drug dosage, drug delivery and duration of treatment are some of the postulated reasons for this outlier. Curcuminoids are lipophilic molecules and their absorption in the gastrointestinal tract can be low and variable [34]. Currently, we do not know whether the therapeutic effects of curcumin depend on its absorption and systemic bioavailability, or are more the result of a topical action on the intestinal mucosa.…”

Section: Discussionmentioning

confidence: 99%

Curcumin use in ulcerative colitis: is it ready for prime time? A systematic review and meta-analysis of clinical trials

Chandan

Mohan

Chandan

et al. 2019

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Background Curcumin, an active ingredient of the Indian herb turmeric (Curcuma longa), has shown promising anti-inflammatory properties. Studies of its potential benefits in treating patients with ulcerative colitis (UC) are limited. We performed a systematic review and meta-analysis of human randomized placebo controlled trials to evaluate the efficacy of adjunctive therapy with curcumin in treating patients with UC. Methods We conducted a search of several databases (from January 2000 to September 2018). A randomeffects model was used for analysis. We assessed heterogeneity between study-specific estimates using the Cochran Q statistical test, 95% prediction interval (PI) and I 2 statistics. The outcomes assessed were the pooled odds of clinical response and remission as well as the endoscopic response. Results A total of 7 studies with 380 patients (curcumin n=188; placebo n=190) were included in the final analysis. The pooled odds ratio for clinical remission with curcumin use was 2.9 (95%CI 1.5-5.5, I 2 =45, P=0.002), clinical response was 2.6 (95%CI 1.5-4.5, I 2 =74%, P=0.001), and endoscopic response/remission was 2.3 (95%CI 1.2-4.6, I 2 =35.5%, P=0.01). Conclusions Based on our study, combined mesalamine and curcumin therapy was associated with roughly threefold better odds of a clinical response compared to placebo, with minimal side effects. This response was statistically significant, albeit with heterogeneity, probably due to the different severity scoring indices, curcumin dosages and routes of drug delivery used.

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“…Curcumin is a polyphenol found in large quantities in the rhizome of Curcuma longa L. (commonly known as turmeric). Curcumin is a safe dietary phytochemical and has a wide range of therapeutic effects, including the acceleration of wound healing, as well as anti‐inflammatory, anticancer, anti‐proliferative, antibacterial, anti‐coagulation, and anti‐atherosclerotic properties 74–85 . The ameliorative role of curcumin in sepsis development has been extensively studied and numerous experiments have been conducted to elucidate its underlying molecular and cellular mechanisms.…”

Section: Treatment Of Sepsis With Polyphenolic Compoundsmentioning

confidence: 99%

The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective

et al. 2020

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Sepsis and septic shock are still a leading cause of mortality and morbidity in intensive care units worldwide. Sepsis is an uncontrolled and excessive response of the innate immune system toward the invading infectious microbes, characterized by the hyper‐production of pro‐inflammatory mediators such as interleukin (IL)‐1β, IL‐6, tumor‐necrosis factor (TNF)‐α, and high‐mobility group box 1 (HMGB1). In severe sepsis, the overwhelming production of pro‐inflammatory cytokines and reactive oxygen species may compromise organ function and lead to the induction of abnormal apoptosis in different organs, resulting in multiple organ dysfunction syndrome and death. Hence, compounds that are able to attenuate inflammatory responses may have therapeutic potential for sepsis treatment. Understanding the pathophysiology and underlying molecular mechanisms of sepsis may provide useful insights in the discovery and development of new effective therapeutics. Therefore, numerous studies have invested much effort into elucidating the mechanisms involved with the onset and development of sepsis. The present review mainly focuses on the molecules and signaling pathways involved in the pathogenicity of sepsis. Additionally, several well‐known natural bioactive herbal compounds and phytochemicals, which have shown protective and therapeutic effects with regard to sepsis, as well as their mechanisms of action, are presented. This review suggests that these phytochemicals are able to attenuate the overwhelming inflammatory responses developed during sepsis by modulating different signaling pathways. Moreover, the anti‐inflammatory and cytoprotective activities of phytochemicals make them potent compounds to be included as complementary therapeutic agents in the diets of patients suffering from sepsis in an effort to alleviate sepsis and its life‐threatening complications, such as multi‐organ failure.

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Biological properties of metal complexes of curcumin

Cited by 82 publications

References 145 publications

Both metal-chelating and free radical-scavenging synthetic pentapeptides as efficient inhibitors of reactive oxygen species generation

Both metal-chelating and free radical-scavenging synthetic pentapeptides as efficient inhibitors of reactive oxygen species generation

Curcumin use in ulcerative colitis: is it ready for prime time? A systematic review and meta-analysis of clinical trials

The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective

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