Diarylheptanoids as nutraceutical: A review

Ganapathy, Gopinath; Preethi, R.; Moses, J.A.; Anandharamakrishnan, C.

doi:10.1016/j.bcab.2019.101109

Cited by 29 publications

(14 citation statements)

References 112 publications

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“…Plant-derived compounds have been used in traditional herbal medicine for treating inflammation ( Chao et al, 2010 , Kohli et al, 2005 ). Several diarylheptanoids obtained from different plant sources were previously reported for their pharmacological properties, which were extensively reviewed ( Ganapathy et al, 2019 ). Previously, Curcumin isolated from the Curcuma longa was reported for its anti-inflammatory potential in both acute and chronic models of inflammation and its anti-inflammatory efficacy was found to be similar to phenylbutazone ( Hewlings and Kalman, 2017 , Srimal and Dhawan, 1973 ).…”

Section: Discussionmentioning

confidence: 99%

ASPP 092, a phenolic diarylheptanoid from Curcuma comosa suppresses experimentally-induced inflammatory ear edema in mice

Chuncharunee

Khosuk

Naovarat

et al. 2021

Saudi Journal of Biological Sciences

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Curcuma comosa Roxb., family Zingiberaceae, exhibits diverse biological activities. This study was aimed to investigate the anti-inflammatory potential of a major phenolic diarylheptanoid isolated from C. comosa , ASPP 092 [(3S)-1-(3,4-dihydroxy-phenyl)-7-phenyl-(6E)-6-hepten-3-ol] in an experimentally-induced inflammatory ear edema model in mice. Ear edema in the mice was induced by the topical application of irritant, ethyl phenylpropiolate (EPP). The topical application of ASPP 092 at the edema site was directed immediately after the EPP application. The edematous responses were assessed at different time points by measuring the thickness of each ear before and after the EPP application followed by histopathology analysis. The expressions of major inflammatory cytokines were analyzed by real-time RT-PCR followed by the immunohistochemistry analysis of cyclooxygenase (COX-2). The topical application of ASPP 092 effectively suppressed the EPP-induced edematous formation in the ear of mice. Histopathological analysis showed substantial improvements in epidermal hyperplasia and inflammatory cell infiltration. ASPP 092 treatment also modulated the expressions of inflammatory cytokines including Tumor Necrosis Factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-1β (IL-1β), and Matrix metalloproteinase-13 (MMP-13). The expressions of cyclooxygenases (COX) including COX-1 and COX-2 were significantly reduced by ASPP 092 treatment. For the first time, our results suggest the efficacy of ASPP 092 to suppress experimentally-induced inflammation in a preclinical model in mice; however, a more detailed evaluation of its mechanism of action is necessary before evaluating its efficacy and safety in randomized trials.

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Section: Discussionmentioning

confidence: 99%

ASPP 092, a phenolic diarylheptanoid from Curcuma comosa suppresses experimentally-induced inflammatory ear edema in mice

Chuncharunee

Khosuk

Naovarat

et al. 2021

Saudi Journal of Biological Sciences

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“…Diarylheptanoids are phenolic compounds with a skeletal structure of two aromatic rings conjugated with seven carbon chains [ 40 ]. Diarylheptanoids have been used as nutraceuticals due to their broad array of health-promoting properties [ 41 ]. Among nutraceuticals, curcumin is an important diarylheptanoid compound, which has been studied widely for its role in protection against many diseases [ 42 ].…”

Section: Polyphenol: Chemistry and Biological Functionmentioning

confidence: 99%

Novel Insights on Dietary Polyphenols for Prevention in Early-Life Origins of Hypertension: A Review Focusing on Preclinical Animal Models

Tain

Hsu

2022

IJMS

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Polyphenols are the largest group of phytochemicals with health benefits. Early life appears to offer a critical window of opportunity for launching interventions focused on preventing hypertension, as increasing evidence supports the supposition that hypertension can originate in early life. Although polyphenols have antihypertensive actions, knowledge of the potential beneficial action of the early use of polyphenols to avert the development of hypertension is limited. Thus, in this review, we first provide a brief summary of the chemistry and biological function of polyphenols. Then, we present the current epidemiological and experimental evidence supporting the early-life origins of hypertension. We also document animal data on the use of specific polyphenols as an early-life intervention to protect offspring against hypertension in adulthood and discuss underlying mechanisms. Continued research into the use of polyphenols to prevent hypertension from starting early in life will have far-reaching implications for future health.

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“…A variety of compounds are present, including diarylheptanoids, dihydrochalcones, triterpenoids and flavonoids, but the majority of the bioactive compounds obtained from Morella and Myrica genera are cyclic diarylheptanoids, a class of compounds known by their wide array of biological activities [63]. From the analysis of Table 1 it is also clear that the compounds which have been more widely studied are myricanone (1), myricanol (4), quercitrin (9), myricitrin (10), and betulin (16), so details about the most interesting works and compounds from Table 1 will be discussed in the following paragraphs.…”

Section: D-glcpymentioning

confidence: 99%

Phytochemicals with Added Value from Morella and Myrica Species

et al. 2020

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Terrestrial plants, due to their sessile nature, are highly exposed to environmental pressure and therefore need to produce very effective molecules that enable them to survive all the threats. Myrica and Morella (Myricaceae) are taxonomically close genera, which include species of trees or shrubs with edible fruits that exhibit relevant uses in traditional medicine. For instance, in Chinese or Japanese folk medicine, they are used to treat diarrhea, digestive problems, headache, burns, and skin diseases. A wide array of compounds isolated from different parts of Myrica and/or Morella species possess several biological activities, like anticancer, antidiabetic, anti-obesity, and cardio-/neuro-/hepatoprotective activities, both in vitro and in vivo, with myricanol, myricitrin, quercitrin, and betulin being the most promising. There are still many other compounds isolated from both genera whose biological activities have not been evaluated, which represents an excellent opportunity to discover new applications for those compounds and valorize Morella/Myrica species.

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Diarylheptanoids as nutraceutical: A review

Cited by 29 publications

References 112 publications

ASPP 092, a phenolic diarylheptanoid from Curcuma comosa suppresses experimentally-induced inflammatory ear edema in mice

ASPP 092, a phenolic diarylheptanoid from Curcuma comosa suppresses experimentally-induced inflammatory ear edema in mice

Novel Insights on Dietary Polyphenols for Prevention in Early-Life Origins of Hypertension: A Review Focusing on Preclinical Animal Models

Phytochemicals with Added Value from Morella and Myrica Species

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