The protective role of curcumin in myocardial ischemia–reperfusion injury

Abstract

Coronary artery disease (CAD) is a well-known pathological condition that is characterized by high morbidity and mortality. The main pathological manifestation of CAD is myocardial injury due to ischemia-reperfusion (I-R). Currently, no efficacious treatment of protecting the heart against myocardial I-R exists. Hence, it is necessary to discover or develop novel strategies to prevent myocardial-reperfusion injury to improve clinical outcomes in patients with CAD. A large body of experimental evidence supports cardioprotective properties of curcumin and the ability of this phytochemical to modify some cardiovascular risk factors. However, the detailed effects of curcumin in myocardial I-R injury are still unclear and there is a lack of evidence concerning which curcumin regimen may be ideal for myocardial I-R injury. This paper presents a brief review of the pathophysiology of myocardial I-R injury and the mechanisms of action of curcumin in reducing myocardial I-R injury.

Dexmedetomidine postconditioning suppresses myocardial ischemia/reperfusion injury by activating the SIRT1/mTOR axis

“…Unsolved and complex MI/R injury, which has been identified as a major factor contributing to mortality, morbidity and disability worldwide, is also a major cause of death in cardiovascular disease patients, leading to severe damage to the myocardium when serious myocardial infarction occurs [7][8][9]. Moreover, there is no practical solution for thoroughly avoiding MI/R injury [10]. In this context, novel therapeutic strategies for MI/R injury are urgently needed.…”

Combination of the ginsenosides Rb3 and Rb2 exerts protective effects against myocardial ischemia reperfusion injury in rats

“…Preventing the occurrence of cardiomyocyte apoptosis has become a target for certain drugs that interfere with MIRI (14,15). It has been reported that curcumin is a potent cardioprotective compound, which may have beneficial effects on MIRI by reducing oxidative stress, preventing inflammation and inhibiting cardiomyocyte apoptosis (16). Numerous studies have indicated that traditional Chinese medicine (TCM) exerts a potent cardioprotective effect on MIRI and may be used as a therapeutic approach for its treatment (17,18).…”

Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases

“…The main pathological manifestation of coronary artery diseases is myocardial injury due to I‐R. Recently, an increasing number of studies, both in vitro and in vivo, revealed that curcumin exerts a potent cardioprotective effect on myocardial I‐R injury, mainly through prevention of inflammation and reduction of oxidative stress (Mokhtari‐Zaer, Marefati, Atkin, Butler, & Sahebkar, ). It is reported that curcumin can improve myocardial I‐R injury by increasing antioxidative activity as evidenced by elevated mitochondrial superoxide dismutase (SOD) and decreased mitochondrial hydrogen peroxide and malondialdehyde (MDA) levels (Y. Yang et al, ).…”