Cumulative Radiation Exposures during Diagnosis and Treatments with Diagnostic Radiology Tools: In Patient with Hepatocellular Carcinoma

Kim, Jung Hyun; Park, Chan; Song, Jang Hyeon; Kim, Yong Tae; Yim, Nam Yeol; Chang, Nam Kyu; Kim, Jae Kyu; Kang, Heoung Keun

doi:10.3348/jksr.2013.69.3.243

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…Dose area product (DAP) was obtained using dose recording system of the angiography unit. ED was calculated by multiplying DAP by a conversion factor (k = 0.15 mSv/Gy.cm 2 ) (2).…”

Section: Methodsmentioning

confidence: 99%

“…Accordingly, there have been increased concerns about the possible harm of concomitant exposure to ionizing radiation from diagnostic studies. Patients with cancer, hepatocellular carcinoma (HCC) in particular, are predisposed to radiation exposure, mostly from therapeutic procedures like transarterial chemoembolization (TACE) and multiphasic dynamic CT (2).…”

Section: Introductionmentioning

confidence: 99%

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Intravoxel incoherent motion (IVIM) analysis of vertebral bone marrow changes after radiation exposure from diagnostic imaging and interventional procedures

et al. 2017

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Background High cumulative radiation dose in cancer patients warrants systemic examination of possible changes in bone marrow. Purpose To assess retrospectively changes in vertebral bone marrow diffusion and perfusion using intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in hepatocellular carcinoma (HCC) patients after exposure to radiation from diagnostic imaging and interventional procedures. Material and Methods A total of 21 IVIM-DWI sets in 20 HCC patients, consisting of baseline and follow-up liver magnetic resonance imaging (MRI) with an interval less than 100 days, were reviewed after varying levels of radiation exposure from transarterial chemoembolization (TACE), multiphase liver CT, and abdominal radiography. IVIM parameters (apparent diffusion coefficient [ADC], true diffusion coefficient [D], pseudodiffusion coefficient [D*], and perfusion fraction [PF]) of vertebral bone marrow were analyzed for significant differences between baseline and follow-up MRI using Wilcoxon signed-rank test, and for correlations with cumulative effective dose, as well as time interval between last radiation exposure and follow-up MRI using Spearman's correlation. Results Compared to baseline MRI, ADC, D*, and PF significantly decreased on follow-up MRI (ADC: median [interquartile range], 0.405 × 10 mm/s [0.364-0.477] versus 0.390 [0.348-0.461]; D*: 24.011 [18.141-29.584] versus 20.815 [15.022-28.347]; PF: 10.960% [8.828-12.985] versus 9.125 [8.606-12.803]) ( P < 0.05). There was no significant difference in D ( P = 0.807). Cumulative effective dose was moderately correlated with decrease in D* (r = 0.434). In addition, longer intervals between last exposure and follow-up MRI showed negative correlations with changes in D and ADC (r = -0.352 and -0.333, respectively). Conclusion Vertebral bone marrow diffusion and perfusion parameters were significantly changed after exposure to medical radiation.

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“…Dose area product (DAP) was obtained using dose recording system of the angiography unit. ED was calculated by multiplying DAP by a conversion factor (k = 0.15 mSv/Gy.cm 2 ) (2).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intravoxel incoherent motion (IVIM) analysis of vertebral bone marrow changes after radiation exposure from diagnostic imaging and interventional procedures

et al. 2017

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Robot-Assisted Transarterial Chemoembolization of Hepatocellular Carcinoma Using a Coaxial Microcatheter Driving Controller-Responder Robot System: Clinical Pilot Study

Kim

Woo

Song

et al. 2023

Journal of Vascular and Interventional Radiology

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Estimation of the Cumulative Exposure Frequency and Cumulative Effective Dose of Diagnostic Medical Radiation in the Korean Population From 2002 to 2010

jongwon

Kim

Park

et al. 2017

Radiation Protection Dosimetry

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Along with increase in the frequency and exposure dose from the diagnostic medical radiation procedures, the public's interest in radiation exposure has also been growing. In this study, in order to estimate the Cumulative Exposure Frequency and the cumulative effective dose of diagnostic medical radiation in the Korean population, we included 680 diagnostic medical radiation procedure codes of the Health Insurance Review & Assessment Service's health insurance medical expenses data and adopted the effective dose data from the 2008 report of the United Nations Scientific Committee on the Effects of Atomic Radiation. We combined the data of one million individuals in the national sample cohort database (2002-10) of the National Health Insurance Service. The results revealed that 93.2% (917 972) of the subjects were exposed to diagnostic medical radiation at least once in the past nine years, and the Cumulative Exposure Frequency was 17 286.4 per 1000 individuals with a cumulative effective dose of 5.7 (±17.8) mSv per person. Additionally, 93.1% (854 480) of the subjects had a cumulative effective dose less than 20 mSv, and 0.7% (6139) had a dose that exceeded 100 mSv (extreme), showing that the dosage level was mostly low. However, the number of individuals whose exposure exceeded 100 mSv/y increased 28-fold, from 18 in 2002 to 500 in 2010. In addition, the size of increase also grew each year, suggesting that cancer occurrence due to diagnostic medical radiation may have also increased. In order determine the causal relationship between cancer occurrence and diagnostic medical radiation and setup a guideline for exposure, it is necessary to monitor individual cumulative exposure doses nation-wide and follow up on heavily exposed individuals for an extended period of time.

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Cumulative Radiation Exposures during Diagnosis and Treatments with Diagnostic Radiology Tools: In Patient with Hepatocellular Carcinoma

Cited by 5 publications

References 21 publications

Intravoxel incoherent motion (IVIM) analysis of vertebral bone marrow changes after radiation exposure from diagnostic imaging and interventional procedures

Intravoxel incoherent motion (IVIM) analysis of vertebral bone marrow changes after radiation exposure from diagnostic imaging and interventional procedures

Robot-Assisted Transarterial Chemoembolization of Hepatocellular Carcinoma Using a Coaxial Microcatheter Driving Controller-Responder Robot System: Clinical Pilot Study

Estimation of the Cumulative Exposure Frequency and Cumulative Effective Dose of Diagnostic Medical Radiation in the Korean Population From 2002 to 2010

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