Crimped nanofiber scaffold mimicking tendon-to-bone interface for fatty-infiltrated massive rotator cuff repair

Wang, Liren; Zhu, Tonghe; Kang, Yuhao; Zhang, Jianguang; Du, Juan; Gao, Haihan; Chen, Sihao; Jiang, Jia; Zhao, Jinzhong

doi:10.1016/j.bioactmat.2022.01.031

Cited by 31 publications

(24 citation statements)

References 57 publications

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“…The critical role of hybrid materials coupled with scaffold architecture was highlighted in recent work. Nanofibrous scaffolds, based on Gelatine/PEUU (poly(ester-urethane)urea) blends, were developed using electrospinning followed by a chemical crosslinking method [ 138 ]. The scaffolds possessed crimped nanofibres and welded joints to biomimic the native microstructure of tendon-to-bone insertion.…”

Section: Biopolymersmentioning

confidence: 99%

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Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments

Heidari

Ruan

Vahabli

et al. 2023

Bioactive Materials

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Section: Biopolymersmentioning

confidence: 99%

“…A continuous translational interface was observed between the tendon and the bone using nanofibrous scaffold three months after rotator cuff repairing in rabbit models. The crimped nanofibre scaffolds not only mechanically matched the native tendon tissue, but also promoted enthesis regeneration by facilitating chondrogenesis [ 138 ].…”

Section: Biopolymersmentioning

confidence: 99%

Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments

Heidari

Ruan

Vahabli

et al. 2023

Bioactive Materials

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“…Poly(ester-urethane) urea and gelatin were electrospun and double crosslinked by a multi-bonding network densification strategy to create nanofiber scaffolds with formed joints to mimic the natural microstructure of tendon-to-bone insertion. However, a crimped nanofiber scaffold (CNS) has been shown to induce chondrogenic differentiation and bionic tensile stress, making it a credible platform for in vivo experiments [ 123 ].…”

Section: Electrospun Fiber Materials For Tendon Repairmentioning

confidence: 99%

Functional biomaterials for tendon/ligament repair and regeneration

Tang

Wang

Xiang

et al. 2022

Regenerative Biomaterials

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With an increase in life expectancy and the popularity of high-intensity exercise, the frequency of tendon and ligament injuries has also increased. Owing to the specificity of its tissue, the rapid restoration of injured tendons and ligaments is challenging for treatment. This review summarises the latest progress in cells, biomaterials, active molecules, and construction technology in treating tendon/ligament injuries. The characteristics of supports made of different materials and the development and application of different manufacturing methods are discussed. The development of natural polymers, synthetic polymers, and composite materials has boosted the use of scaffolds. In addition, the development of electrospinning and hydrogel technology has diversified the production and treatment of materials. First, this paper briefly introduces the structure, function, and biological characteristics of tendons/ligaments. Then, it summarises the advantages and disadvantages of different materials, such as natural polymer scaffolds, synthetic polymer scaffolds, composite scaffolds, and ECM-derived biological scaffolds, in the application of tendon/ligament regeneration. We then discuss the latest applications of electrospun fiber scaffolds and hydrogels in regeneration engineering. Finally, we discuss the current problems and future directions in the development of biomaterials for restoring damaged tendons and ligaments.

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“…A total of 24 articles [ [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] ] are included in this special issue. These articles can be categorized in terms of authors, biomaterials and targeted clinical areas, and article types.…”

mentioning

confidence: 99%

“…Several articles in this special issue are on regulatory science and discuss the new standards, tools, and approaches to evaluate the safety, efficacy, quality, and performance of medical products [ 10 , 13 , 17 , 19 ]. This special issue also covers a wide range of article types including research article [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , 11 , 12 , 15 , 16 , [18] , [19] , [20] , [23] , [24] , [25] , [26] ], reviews [ 14 , 17 , 21 , 22 , 27 ], perspectives [ 10 , 13 ] and opinion paper [ 18 ].…”

mentioning

confidence: 99%